A5050072571- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Innovations in Medical Education
- Trauma and Emergency Care Studies
- Pancreatic and Hepatic Oncology Research
- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Surgical Simulation and Training
- Liver physiology and pathology
- Alcohol Consumption and Health Effects
- Venous Thromboembolism Diagnosis and Management
- Trauma Management and Diagnosis
- Tissue Engineering and Regenerative Medicine
- Radiomics and Machine Learning in Medical Imaging
- Emergency and Acute Care Studies
- Xenotransplantation and immune response
- Esophageal and GI Pathology
The University of Texas Southwestern Medical Center
2020-2025
Southwestern Medical Center
2022-2025
Children's Medical Center
2022-2025
Saint Louis University Hospital
2025
Neurology, Inc
2025
Scripps MD Anderson Cancer Center
2024
William P. Clements Jr. University Hospital
2024
Toronto General Hospital
2020-2022
University Health Network
2020-2022
Beth Israel Deaconess Medical Center
2016-2021
Since the first attempt of pig-to-primate liver xenotransplantation (LXT) in 1968, survival has been limited. We evaluated a model utilizing α-1,3-galactosyltransferase knockout donors, continuous posttransplant infusion human prothrombin concentrate complex, and immunosuppression including anti-thymocyte globulin, FK-506, methylprednisone, costimulation blockade (belatacept, n = 3 or anti-CD40 mAb, 1) to extend survival. Baboon 1 remained well until postoperative day (POD) 25, when...
Abstract More liver transplants (LT) are performed worldwide thanks to extended criteria donors (ECD). This is paralleled by a supposed increased risk of allograft failure (AF) at 90 and 365 days. study has been designed portray the LT practice investigate models AF prediction impact mitigation strategies for further improving graft patient outcomes. multicenter, international, non-competitive, observational two segment on consecutive LTs over periods (2017–2019 2022–2024). A steering...
Hollow viscus injuries (HVI) are uncommon after blunt trauma, and accomplishing a timely diagnosis can be difficult. Time to operative intervention has been implicated as risk factor for mortality, but reports conflicting.All trauma admissions an academic level 1 center from January 1992 September 2005 were retrospectively reviewed. Patients with of HVI included. who died within 24 hours excluded. Data regarding patient demographics, injuries, time admission until laparotomy, length stay,...
Many organ procurement organizations have implemented critical care end points as donor management goals in efforts to increase organs transplanted per after neurologic determination of death. Although retrospective studies demonstrated an association between meeting and yield, prospective are lacking.In June 2008, nine were prospectively a checklist every death was managed meet them. The represented normal cardiovascular, pulmonary, renal, endocrine points. Data collected for 7 months....
There is a national shortage of organs available for transplantation. Implementation preset donor management goals (DMGs) to improve outcomes recommended, but uniform practices and data are lacking. We hypothesized that meeting DMGs before organ procurement would result in more transplanted per (OTPD).The eight organization United Network Organ Sharing Region 5 selected 10 critical care end points as DMGs. Each submitted retrospective from 40 standard criteria donors. "DMGs met" was defined...
The shortage of organs available for transplant has led to the use expanded criteria donors (ECDs) extend donor pool. These are older and have more comorbidities efforts optimize quality their needed.To determine impact meeting a standardized set critical care end points, or management goals (DMGs), on number transplanted per in ECDs.Prospective interventional study from February 2010 July 2013 all ECDs managed by 8 organ procurement organizations southwestern United States (United Network...
Many organ procurement organizations (OPOs) utilize preset critical care endpoints as donor management goals (DMGs) in order to standardize and improve outcomes. The objective of this study was determine the impact meeting DMGs on delayed graft function (DGF) renal transplant recipients. All eight OPOs United Network for Organ Sharing Region 5 prospectively implemented nine every after neurologic determination death (DNDD). "DMGs met" defined a priori achieving any seven recorded at time...
Following liver resection (LR) for HCC, the likelihood of survival is dynamic, in that multiple recurrences and/or metastases are possible, each having variable impacts on outcomes. We sought to evaluate natural progression, pattern, and timing various disease states after LR HCC using multistate modeling create a practical calculator provide prognostic information patients clinicians.Adult undergoing between January 2000 December 2018 were retrospectively identified at single center....
Background. Emerging data suggest disparities exist in liver transplantation (LT) for alcohol-associated disease (ALD). As the incidence of ALD increases, we aimed to characterize recent trends LT frequency and outcomes, including racial ethnic disparities. Methods. Using United Network Organ Sharing/Organ Procurement Transplantation (2015 through 2021), evaluated frequency, waitlist mortality, graft survival among US adults with (alcohol-associated hepatitis [AH] cirrhosis [AAC]) stratified...
Liver transplantation (LT) listing criteria for hepatocellular carcinoma (HCC) remain controversial. To optimize the utility of limited donor organs, this study aims to leverage machine learning develop an accurate posttransplantation HCC recurrence prediction calculator. Patients with listed LT from 2000 2016 were identified, 739 patients who underwent used modeling. Data included serial imaging, alpha-fetoprotein (AFP), locoregional therapies, treatment response, and outcomes. We compared...
Importance Delayed graft function in kidney-transplant recipients is associated with increased financial cost and patient burden. In donors high Kidney Donor Profile Index whose kidneys are not pumped, therapeutic hypothermia has been shown to confer a protective benefit against delayed function. Objective To determine whether superior normothermia preventing low-risk nonpumped kidney after brain death. Design, Setting, Participants multicenter randomized clinical trial, brain-dead deemed be...
Our objective was to evaluate the impact of hydroxyethyl starch (HES) use in organ donors after neurologic determination death (DNDD) on recipient renal graft outcomes. The following data elements were prospectively collected for every DNDD managed by a single procurement organization from June 2011 July 2013: demographics; critical care endpoints; treatments, including HES; cold ischemia time (CIT); and occurrence delayed function (DGF, dialysis first week transplantation). Logistic...