A5072009798- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Economic and Financial Impacts of Cancer
- Pregnancy and Medication Impact
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Hepatitis C virus research
- Cancer survivorship and care
- Cancer, Lipids, and Metabolism
- Breastfeeding Practices and Influences
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Liver Diseases and Immunity
- Tuberous Sclerosis Complex Research
- Neonatal Respiratory Health Research
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Reproductive tract infections research
- Organ Transplantation Techniques and Outcomes
- Hops Chemistry and Applications
- Birth, Development, and Health
- Global Cancer Incidence and Screening
- Alcohol Consumption and Health Effects
- Radiomics and Machine Learning in Medical Imaging
The University of Texas Southwestern Medical Center
2022-2025
Southwestern Medical Center
2022-2025
Parkland Health & Hospital System
2024
American University of Beirut
2021-2022
Importance Cohort studies demonstrating an association of hepatocellular carcinoma (HCC) screening with reduced mortality are prone to lead-time and length-time biases. Objective To characterize the clinical benefits HCC screening, adjusting for biases, in a diverse, contemporary cohort at-risk patients. Design, Setting, Participants This retrospective study patients was conducted between January 2008 December 2022 at 2 large US health systems. Data analysis performed from September November...
Abbreviated MRI (AMRI) has been proposed as an alternative to ultrasound for hepatocellular carcinoma (HCC) surveillance; however, comparative data AMRI and are needed. Thus, we evaluated the sensitivity specificity of dynamic contrast-enhanced (DCE)-AMRI early-stage HCC detection in patients with cirrhosis. We conducted a multicenter retrospective case-control study among cirrhosis (cases per Milan Criteria; controls without HCC) who underwent DCE-MRI within 6-month period between 2012...
Hepatocellular carcinoma (HCC) surveillance is associated with improved early tumor detection, but effectiveness limited by underuse. We characterized adherence to HCC using proportion of time covered (PTC) and estimated its association clinical outcomes among patients cirrhosis.
Background Hepatocellular carcinoma (HCC) is plagued by failures across the cancer care continuum, leading to frequent late-stage diagnoses and high mortality. We evaluated effectiveness of mailed outreach invitations plus patient navigation promote HCC screening process completion in patients with cirrhosis. Methods Between April 2018 September 2021, we conducted a multicentre pragmatic randomised clinical trial comparing for (n=1436) versus usual visit-based among cirrhosis at three US...
Background: Hepatocellular carcinoma (HCC) surveillance is underused in clinical practice, and few contemporary data have assessed patients’ perceptions of effectiveness net benefit. Methods: We conducted a survey study among adult patients with cirrhosis at 7 health systems the United States. The was based on validated measures, when available, patient knowledge about HCC surveillance, attitudes regarding benefits harms, perceived risk, trust their doctors. Results: Respondents (n=665;...
Summary Background/Aims Patients with hepatocellular cancer (HCC) are vulnerable to psychological distress given a new diagnosis superimposed on pre‐existing chronic liver disease. We aimed characterise the psychiatric burden in HCC, risk factors for incident and treatment patterns over time. Methods Using IQVIA PharMetrics® Plus Academics—a nationally representative claims database of commercially insured US population—we identified diagnoses among patients newly diagnosed HCC....
Background: Growing evidence suggests that liver disease originates in early life. Antihistamines cross the placenta and are frequently prescribed to pregnant women treat nausea vomiting, as well allergy asthma symptoms. Exposure antihistamines utero may impact developing by reprogramming or inducing epigenetic changes fetal hepatocytes. Methods: We examined exposure risk of HCC Child Health Development Studies, a multigenerational cohort enrolled East Bay, CA, between 1959 1966 (n=14,507...
Abstract Background The value of hepatocellular carcinoma screening is defined by the balance benefits from early tumor detection vs harms because false-positive results. We evaluated a mailed outreach strategy for in patients with cirrhosis. Methods conducted multicenter pragmatic randomized clinical trial comparing (n = 1436) and usual care visit-based among cirrhosis at 3 health systems March 2018 to September 2021. Outcomes interest were stage (ie, benefit) diagnostic evaluation or...
Racial and ethnic disparities have been reported for HCC prognosis, although few studies fully account clinically important factors social determinants of health, including neighborhood socioeconomic status.
Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits relatively less adverse effects compared other drugs; however, growing evidence clearly indicates that cannabis associated with considerable cardiovascular events. Recent studies have linked use myocardial infarction (MI); yet, very little known about underlying mechanisms. A MI a disease characterized by mismatch...