A5061621001- Immune cells in cancer
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Alcohol Consumption and Health Effects
- Cannabis and Cannabinoid Research
- Gastric Cancer Management and Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tryptophan and brain disorders
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Signaling Pathways in Disease
- Eicosanoids and Hypertension Pharmacology
- Coffee research and impacts
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Histone Deacetylase Inhibitors Research
- HIV Research and Treatment
- IL-33, ST2, and ILC Pathways
- Cancer-related gene regulation
Hospital Infantil de México Federico Gómez
2015-2024
University of Miami
2023-2024
Instituto Nacional de Neurología y Neurocirugía
2022-2024
Sylvester Comprehensive Cancer Center
2024
Universidad Nacional Autónoma de México
2021-2023
Secretaria de Salud
2021
Florida International University
2013-2018
Mexican Social Security Institute
2015
TLRs and NLRs participate in the immune system recognition of Helicobacter pylori. However, little is known about mechanisms leading to inflammasome activation by H. pylori if neutrophils are involved process. We studied how NOD-like receptor family, pyrin domain-containing 3 (NLRP3) components IL-1β maturation human response infection they dependent on T4SS (type IV secretion system) TLRs. Human were cultured infected with 26695 or VirD4- strains; concentration was analyzed ELISA, we also...
Racial and ethnic disparities have been reported for HCC prognosis, although few studies fully account clinically important factors social determinants of health, including neighborhood socioeconomic status.
During human immunodeficiency virus (HIV) infection, alcohol has been known to induce inflammation while cannabinoids have shown an anti-inflammatory role. For instance reduce susceptibility HIV-1 infection and attenuate HIV replication in macrophages. Recently, we demonstrated that induces cannabinoid receptors regulates cytokine production by monocyte-derived dendritic cells (MDDC). However, the ability of alter MDDC function during not clearly elucidated yet. In order study potential...
Cancer is the second most common cause of death among children aged 1-14 years. Leukemia accounts for one-third all childhood cancers, 78% which acute lymphoblastic leukemia (ALL). The development cancer has been associated with malignant cells that express low levels immunogenic molecules, facilitates their escape from antineoplastic immune response. It thought it may be possible to rescue response through activation recognition receptors, such as Toll-like receptors (TLRs), activate innate...
Dendritic cells (DCs) are antigen presenting of the immune system that play a crucial role in lymphocyte responses, host defense mechanisms, and pathogenesis inflammation. Isolation study DCs have been important biological research because their distinctive features. Although they essential key mediators system, very rare blood, accounting for approximately 0.1 - 1% total blood mononuclear cells. Therefore, alternatives isolation methods rely on differentiation from monocytes isolated...
Epigenetic mechanisms have been shown to play a role in alcohol use disorders (AUDs) and may prove be valuable therapeutic targets. However, the involvement of histone deacetylases (HDACs) on alcohol-induced oxidative stress human primary monocyte-derived dendritic cells (MDDCs) has not elucidated. In current study, we took novel approach combining ex vivo, vitro silico analyses elucidate HDACs periphery. vivo alcohol-modulation class I activity by MDDCs from self-reported users non-alcohol...
Aminopeptidase N, or CD13, is a cell membrane ectopeptidase highly expressed in myeloid cells. Through its enzymatic activity, CD13 regulates the activity of several bioactive peptides, such as endorphins and enkephalins, chemotactic peptides like MCP-1 IL-8, angiotensin III, bradikinin, etc. In recent years, it has been appreciated that independently peptidase can activate signal transduction pathways mediate effector functions phagocytosis cytokine secretion monocytes macrophages. Although...
Previous reports on epigenetic mechanisms involved in alcohol abuse have focus hepatic and neuronal regions, leaving the immune system specifically monocyte-derived dendritic cells (MDDCs) understudied. Our lab has previously shown histone deacetylases are modulated derived from users after vitro acute treatment of human MDDCs. In current study, we developed a novel screening tool using matrix assisted laser desorption ionization-fourier transform-ion cyclotron resonance mass spectrometry...
Natural killer (NK) cells play a crucial role in innate immunity, particularly combating infections and tumors. However, hematological cancers, NK often exhibit impaired functions. Therefore, it is very important to activate its endosomal toll-like receptors (TLRs) as potential strategy restore antitumor activity. We stimulate from the peripheral blood mononuclear children with acute lymphoblastic leukemia isolated, were stimulated specific TLR ligands (Poly I:C, Imiquimod, R848, ODN2006)...
Dendritic cells (DCs) are antigen presenting of the immune system that play a crucial role in lymphocyte responses, host defense mechanisms, and pathogenesis inflammation. Isolation study DCs have been important biological research because their distinctive features. Although they essential key mediators system, very rare blood, accounting for approximately 0.1 - 1% total blood mononuclear cells. Therefore, alternatives isolation methods rely on differentiation from monocytes isolated...
The objective of this study was to understand whether histone deacetylase (HDACs) inhibitor Trichostatin A or TSA can block and/or reverse chronic alcohol exposure-induced ROS in human monocyte-derived dendritic cells (MDDCs). Additionally, since nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a known regulator antioxidant responses, we studied the effects and on production modulation Nrf2 by MDDCs.Intra-cellular, extra-cellular, total levels were measured MDDCs treated chronically...
Natural killer (NK) cells play a crucial role in innate immunity, particularly combating infections and tumors. However, hematological cancers, NK often exhibit impaired functions. Therefore, it is very important to activate its endosomal Toll-like receptors (TLRs) as potential strategy restore antitumor activity. We stimulated from the peripheral blood mononuclear children with acute lymphoblastic leukemia isolated, were specific TLR ligands (Poly I:C, Imiquimod, R848, ODN2006) we evaluated...
Abstract Background Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopaminergic neurons in substantia nigra , which promotes sustained inflammatory environment central nervous system. Regulatory T cells (Tregs) play an important role control inflammation and might neuroprotective role. Indeed, decrease Treg number function has been reported PD. In this context, pramipexole, receptor agonist used to treat PD symptoms, shown increase peripheral...
The β2 integrin CD11b/CD18, also known as complement receptor 3 (CR3), and the moonlighting protein aminopeptidase N (CD13), are two myeloid immune receptors with overlapping activities: adhesion, migration, phagocytosis of opsonized particles, respiratory burst induction. Given their common functions, shared physical location, fact that some can activate a selection integrins, we hypothesized CD13 could induce CR3 activation through an inside-out signaling mechanism possibly have influence...
Regulatory cells are critical for maintaining immune homeostasis in the central nervous system. cell populations have been reported to control neuroinflammation neurodegenerative conditions like Parkinson’s disease, multiple sclerosis, myasthenia gravis, encephalomyelitis, and Alzheimer’s disease by protecting neurons through different mechanisms, including production of cytokines such as IL-10 TGF-β, promoting expression inhibitory receptors (PD1, TIM3, LAG3), inducing tolerance cell-cell...