A5102839565- Crime Patterns and Interventions
- Rheumatoid Arthritis Research and Therapies
- Criminal Justice and Corrections Analysis
- Systemic Lupus Erythematosus Research
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Child Abuse and Trauma
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal synovial abnormalities and treatments
- Crime, Illicit Activities, and Governance
- Homelessness and Social Issues
- Systemic Sclerosis and Related Diseases
- Dermatological and Skeletal Disorders
- Immunotherapy and Immune Responses
- Risk and Safety Analysis
- Cell Adhesion Molecules Research
- Oral Health Pathology and Treatment
- Inflammatory Bowel Disease
- Social and Intergroup Psychology
- Extracellular vesicles in disease
- Suicide and Self-Harm Studies
- Microscopic Colitis
- CAR-T cell therapy research
- Resilience and Mental Health
- Orthopedic Infections and Treatments
Agostino Gemelli University Polyclinic
2017-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2024
University of Manchester
2019-2024
Institute of Criminology
2013-2021
Università Cattolica del Sacro Cuore
2015-2020
Queen Mary University of London
2014-2017
University of the Sacred Heart
2017
Liverpool Hope University
2016
Kriminologische Zentralstelle
2014
University of Cambridge
2011-2014
Psoriatic arthritis (PsA) is a chronic inflammatory associated with psoriasis. A third of psoriatic patients develop PsA via unknown mechanisms. No reliable diagnostic markers are available for PsA, or prognostic biomarkers development in We previously uncovered pro-inflammatory role cathelicidin LL37 lesional psoriasis skin. binds nucleic acids and stimulates plasmacytoid/myeloid dendritic cells (pDC, mDCs) to secrete type I interferon (IFN-I) factors. becomes an autoantigen Th1-Th17/CD8 T...
Prostate-specific antigen (PSA) and the related kallikrein family of serine proteases are current or emerging biomarkers for prostate cancer detection progression. Kallikrein 4 ( KLK4 /hK4) is particular interest, as mRNA has been shown to be elevated in cancer. In this study, we now show that comparative expression hK4 protein tissues, compared with benign glands, greater than PSA 2 KLK2 /hK2), suggesting may play an important functional role progression addition its biomarker potential. To...
To define the synovial characteristics of patients with rheumatoid arthritis (RA) and psoriatic (PsA) in clinical ultrasound remission achieved by combination therapy methotrexate (MTX) tumour necrosis factor (TNF) blockers.Patients RA (n=25) (disease activity score (DAS)<1.6 for at least 6 months), low disease (LDA) (n=10) (1.6<DAS<2.4 months) PsA (n=18) (DAS<1.6 Psoriasis Area Severity Index (PASI)=0 MTX+anti-TNF (adalimumab 40 mg or etanercept 50 mg) power Doppler (PDUS)-negative...
Objective This study applied a synovitis score obtained during routine care from ultrasound (US)–guided biopsies of synovial tissue (ST) in patients with rheumatoid arthritis (RA) and other inflammatory noninflammatory joint diseases to identify pretreatment biomarkers associated disease characteristics, integrate the findings into multiparameter nomogram for use baseline prediction diagnosis treatment response treatment‐naive patients. Methods The enrolled total 1,015 various autoimmune...
Primary Sjögren’s disease is primarily driven by B-cell activation and associated with a high risk of developing non-Hodgkin’s lymphoma (NHL). Over the last few decades, microRNA-155 (miR-155) has arisen as key regulator B-cells. Nevertheless, its role in primary remains elusive. Thus, purpose this study was (i) to explore miR-155, activating factor (BAFF)-receptor (BAFF-R), Interleukin 6 receptor (IL-6R) expression labial salivary glands (LSG) patients disease, aiming identify potential...
Background Mental health professionals increasingly carry out risk assessments to prevent future violence by their patients. However, there are problems with accuracy and these do not always translate into successful management. Objectives Our aim was improve the of assessment identify factors that causal be targeted clinicians ensure good objectives were investigate key risks at population level, construct new static dynamic instruments, test validity models management using Bayesian...
Abstract Overweight/obesity influence disease burden and clinical outcome of Rheumatoid Arthritis (RA). The impact overweight/obesity on synovial tissue (ST) inflammation is largely unknown. Here, we investigated the histological transcriptional signature ST obtained from RA in different phases (disease onset, failure to first-line conventional DMARDs sustained ultrasound remission) finding that overweight/obese naive showed higher likelihood follicular synovitis, IHC scores for sublining...
Objectives To develop an intensive training programme for ultrasound (US)-guided synovial tissue (ST) biopsy on knees and wrists in inflammatory arthritis to assess the learning curve, patient tolerability, sample quality trainees’ expectations. Methods Active or remission rheumatoid patients were enrolled. Nine trainees joined 4-month a centre experienced performing US-guided ST biopsies consisting of four sequential phases: (1) observation, (2) performance guided step-by-step phases, (3)...
Differential diagnosis among psoriatic arthritis (PsA) and seronegative rheumatoid (Abneg RA) can be challenging particularly in the clinical setting of peripheral phenotype autoantibodies seronegativity. The aim study was to identify synovial tissue (ST) biomarkers differentially expressed PsA Abneg RA test their predictive value therapeutic response.Thirty-four patients [12 DMARD naive 22 non-responder methotrexate (MTX-IR)] with joint involvement 55 (27 28 MTX-IR) underwent US-guided ST...
Lamellar Ichthyosis (LI) is a form of congenital ichthyosis that caused by mutations in the TGM1 gene encodes for transglutaminase 1 (TG1) enzyme. Functional inactivation TG1 could be due to mutations, deletion or insertions. In this study, we have screened 16 patients affected LI and found six new mutations: two transition/transversion (R37G, V112A), nonsense putative splice site both leading premature stop codon. The are localized exons 2 (N-terminal domain), 5, 11 (central catalytic none...
Objectives: To examine synovial tissue (ST) predictors of clinical differentiation in patients with seronegative undifferentiated peripheral inflammatory arthritis (UPIA). Methods: Fourty-two IgA/IgM-Rheumatoid Factor and anti-citrullinated peptide antibodies negative UPIA, naive to Disease-Modifying Anti-Rheumatic Drugs, underwent Gray Scale (GSUS) power Doppler (PDUS) evaluation Ultrasound (US) guided ST biopsy. CD68, CD3, CD21, CD20, CD31 expression was evaluated by immunohistochemistry....
Abstract Heterozygous mutations in TP63 cause a wide spectrum of autosomal dominant developmental disorders variably affecting skin, limbs, and face. encodes p63, protein expressed two main isoforms (Tap63 ΔNp63) with critical roles both cell differentiation development. Some analyses suggest relationship the mutation site to observed clinical picture, although this link is inconsistent. This suggests an appreciable phenotypic continuity within ‐related disorders. We report 3‐month‐old boy...
Objective Paradoxical arthritis under tumour necrosis factor inhibitor (TNF-i) for inflammatory bowel disease (IBD) has been described. This study aims to evaluate the histological features of paired synovial tissue (ST) and colonic mucosa (CM) in patients with IBD developing paradoxical TNF-i. Methods Patients without history coexisting joint involvement who developed TNF-i were enrolled. Each patient underwent ST biopsy ileocolonoscopy CM biopsies. samples stained through...
Traditionally, Japan has been regarded as a country with low crime. Comparative research given insights into the extent of similarities and differences in crime between America Japan. The importance these studies is examination whether Western-established criminological knowledge applicable to non-Western societies like Unfortunately, comparative self-report involving investigating youth offending are scarce. current study investigates risk factors self-reports violence from Osaka Seattle...
Contemporary criminology issues are increasingly global, cross-cultural, and multilingual. Moreover, students from different cultural national backgrounds will need to apply data analytics in their respective contexts. Crime used statistical courses should reflect this diversity, turn enhance the equality inclusivity of teaching curriculum. Supported by evidence-based pedagogic principles evaluations, researchers have identified strategies learning quantitative skills. Promoting students'...
Abstract This article examines culture, an ambiguous yet prevalent concept in comparisons of crime and justice. It investigates the extent to which culture’s application meaning across research reflects Western-centric bias criminological knowledge-production despite it being a meant advance understanding on different groups places beyond “Western” worldview. The extends discussion but also culture criminology by tracing use this East Asian populations identifying patterns international...
Public health psychiatry has a key role in violence prevention. Cross-national comparisons of and associated psychiatric morbidity can indicate targets for preventive interventions.Data on young adult men households, 18-34 years, were drawn from the Second Men's Modern Lifestyles survey Great Britain (n = 2046) corresponding Chengdu, China 4132), using translated questionnaire. Binary logistic regression models carried out to estimate cross-national differences different types identify...
In Japan, concerns toward contemporary youth offending and violence have resulted in multiple changes the treatment of youth. These are result negative societal perceptions following a string violent youth-on-youth murders media sensationalizing juvenile crimes. Compared to what is known about male criminality, very little female particularly important risk promotive factors for delinquency. Using factor prevention paradigm, study investigates potential delinquency 219 Osaka youths, aged...
Probation officers have large caseloads with high levels of psychiatric morbidity but receive minimal training in recognising/managing mental health problems. In the UK, there is no national screening procedure for illness among offenders that considered effective. This study's aim was to develop a system mental/personality disorders using Offender Assessment System. Seven screens disorder were developed items from assessments on 574 prisoners: alcohol misuse, drug dependence, antisocial...