A5103222075- Cutaneous Melanoma Detection and Management
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Inflammatory Bowel Disease
- Rheumatoid Arthritis Research and Therapies
- Amyotrophic Lateral Sclerosis Research
- Spondyloarthritis Studies and Treatments
- Acute Ischemic Stroke Management
- Meningioma and schwannoma management
- CAR-T cell therapy research
- Nonmelanoma Skin Cancer Studies
- Systemic Sclerosis and Related Diseases
- Neurological disorders and treatments
- Cancer and Skin Lesions
- Microscopic Colitis
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Neurofibromatosis and Schwannoma Cases
- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Vasculitis and related conditions
- Heparin-Induced Thrombocytopenia and Thrombosis
- Genetic and rare skin diseases.
- Eosinophilic Disorders and Syndromes
- Traumatic Brain Injury and Neurovascular Disturbances
Università Cattolica del Sacro Cuore
2008-2024
Agostino Gemelli University Polyclinic
2018-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2021
University of Bari Aldo Moro
1982-2013
Catholic University of America
2011
Amyotrophic lateral sclerosis (ALS) has heterogeneous clinical features that could be translated into specific patterns of brain atrophy. In the current study we have evaluated relationship between different expressions classical ALS and measurements cortical thickness. Cortical thickness analysis was conducted from 3D-MRI using FreeSurfer software in 29 patients 20 healthy controls. We explored three traits disease, subdividing two groups for each them: bulbar or spinal onset, higher lower...
To evaluate the role of proton MR spectroscopy (1H-MRS) in detecting metabolic changes diffuse or focal lesions brain patients infected with HIV.Sixty HIV seropositive (25 related encephalopathies, 20 toxoplasmosis, eight progressive multifocal leukoencephalopathies (PMLs), and seven lymphomas) 22 seronegative neurological controls were examined a combined MRI 1H-MRS technique using Siemens 1.5 Tesla Magnetom. Spectra (Spin Echo sequence, TE 135 ms) acquired by single voxel, localised on...
<h3>Objective</h3> To determine the correlation between metabolite concentrations and clinical outcome during acute or subacute phase of ischemic stroke by using single-voxel localized proton magnetic resonance spectroscopy (<sup>1</sup>H-MRS). <h3>Setting</h3> A university hospital neurologic department. <h3>Patients Methods</h3> Combined single-voxel<sup>1</sup>H-MRS imaging were performed on 26 patients with a recent (on 8 first 24 hours after 18 week). For all patients, signals...
Objectives: To examine synovial tissue (ST) predictors of clinical differentiation in patients with seronegative undifferentiated peripheral inflammatory arthritis (UPIA). Methods: Fourty-two IgA/IgM-Rheumatoid Factor and anti-citrullinated peptide antibodies negative UPIA, naive to Disease-Modifying Anti-Rheumatic Drugs, underwent Gray Scale (GSUS) power Doppler (PDUS) evaluation Ultrasound (US) guided ST biopsy. CD68, CD3, CD21, CD20, CD31 expression was evaluated by immunohistochemistry....
Objective Paradoxical arthritis under tumour necrosis factor inhibitor (TNF-i) for inflammatory bowel disease (IBD) has been described. This study aims to evaluate the histological features of paired synovial tissue (ST) and colonic mucosa (CM) in patients with IBD developing paradoxical TNF-i. Methods Patients without history coexisting joint involvement who developed TNF-i were enrolled. Each patient underwent ST biopsy ileocolonoscopy CM biopsies. samples stained through...
The presence of tumor-infiltrating lymphocytes (TIL) has been associated with a favorable prognosis primary melanoma (PM). recent development the artificial intelligence (AI) based approach in digital pathology proposed for standardized assessment TIL on hematoxylin and eosin (H&E)-stained images (whole slide images, WSI). Here, we have applied new convolution neural network (CNN) analysis PM WSI to automatically assess infiltration TILs extract score. A CNN was trained validated...
Gingival metastases are very rare and generally occur in disseminated tumors. We report a case of solitary gingival metastasis lung cancer. the 74-year-old asymptomatic Caucasian woman affected by rapidly growing, painless swelling. Histopathologic examination excisional biopsy showed poorly differentiated thyroid transcription factor 1-positive adenocarcinoma. A total-body computed tomographic scan revealed tumor right lower lobe with ipsilateral, mediastinal lymph node Moreover, bone...
Immune checkpoint inhibitors have shown efficacy in the treatment of different cancers by stimulating antitumoral activity patient's immune system, representing a major breakthrough field cancer therapy. Monoclonal antibodies including anti-cytotoxic T-lymphocyte-associated protein 4, anti-programmed cell death 1 and its ligand been approved for advanced melanoma among other solid cancers. Although immunotherapy demonstrated good safety profile, new spectrum multisystemic immune-related...
<h3>Background</h3> Undifferentiated Peripheral Inflammatory Arthritis (UPIA) is a common diagnosis at the first clinical evaluation in rheumatological settings. However, likelihood of developing well-defined rheumatic disease UPIA patients still matter debate. <h3>Objectives</h3> To examine role ultrasound (US) and histological parameters outcome with seronegative UPIA. <h3>Methods</h3> Fourty-two IgA/IgM-Rheumatoid Factor anti-citrullinated peptide antibodies negative UPIA, naïve to any...
Every defect is a treasureQuality problems that result in adverse outcomes provide opportunities for quality improvement.A series based on actual examples of care.
Abstract Over the past decade, dupilumab, a monoclonal human antibody that inhibits interleukin (IL)-4 and IL-13 signalling, has revolutionized therapeutic management of moderate-to-severe atopic dermatitis (AD), facilitating long-term control its signs symptoms. The aim this study was to identify histological predictors efficacy dupilumab after 16 weeks treatment in cohort 40 adults with AD who had undergone skin biopsy for diagnostic purposes before initiation. We found Eczema Area...
Clear cell neoplasms of the jaw are very infrequent and a review literature reports only isolated cases metastatic renal clear carcinoma jaw.A 68-year-old man presented with an osteolytic lesion left hemimandible. The first diagnostic hypothesis was third molar follicular cyst. Surgical treatment consisted enucleating preserving alveolar nerve extracting retained tooth. Unexpectedly, as solid.The authors report case neoplasm involving in which histopathological exam indeterminate histology....
<h3>Background</h3> Dendritic cells (DCs) direct the immune response against pathogens while maintaining self-tolerance by instructing T/B in lymphoid organs and peripheral tissues. However, their aberrant activation can lead to chronic inflammation autoimmunity. Based on distinct transcriptomics, function distribution, DCs be broadly categorised as plasmacytoid myeloid (conventional) DCs. recent single sequencing secretome data, divided into CD141<sup>+</sup> (DC1), DC2_A (DC2) defined...
Background: Mohs micrographic surgery (MMS) represents the preferred surgical approach for basal cell carcinoma (BCC) with high-risk features. Delineation of tumor margins prior to influences number stages. Line-field confocal optical coherence tomography (LC-OCT) is a new in-vivo tool that produces skin images in three modes (vertical, horizontal, and 3D) down dermis.Objective: To estimate feasibility LC-OCT presurgical assessment BCCs before MMS, investigate whether evaluation resulted low...