A5082489323- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Bowel Disease
- Inflammatory Myopathies and Dermatomyositis
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Ocular Diseases and Behçet’s Syndrome
- Vasculitis and related conditions
- Celiac Disease Research and Management
- Retinal and Optic Conditions
- Thyroid Disorders and Treatments
- Pregnancy and Medication Impact
- Diabetes and associated disorders
- Therapeutic Uses of Natural Elements
- Otitis Media and Relapsing Polychondritis
- Biosimilars and Bioanalytical Methods
- Musculoskeletal synovial abnormalities and treatments
- Extracellular vesicles in disease
- Eosinophilic Esophagitis
- Inflammasome and immune disorders
- Renal Diseases and Glomerulopathies
- Autoimmune and Inflammatory Disorders
- Autoimmune Bullous Skin Diseases
University of Rome Tor Vergata
2020-2025
University of Molise
2023
Center for Rheumatology
2021
University of Pisa
2013
Objective Evaluate spondyloarthritis (SpA) incidence in inflammatory bowel diseases (IBD) between patients treated with biological disease-modifying antirheumatic drugs (bDMARDs) and conventional DMARDs (cDMARDs) define risk factors associated SpA development. Methods Retrospective cohort study was conducted on Crohn’s disease (CD) or ulcerative colitis (UC) divided into two cohorts: cDMARDs bDMARDs/targeted synthetic (ts) patients. Rheumatological assessment performed presenting...
An accurate prediction of cardiovascular (CV) risk in patients with Axial Spondyloarthritis (axSpA) is a strong unmet need, as CV algorithms poorly perform these subjects. The aim this study was to establish whether the persistence high C-reactive protein (CRP) and disease activity may be considered predictive factors CVD axSpA. 295 without personal history CVD, were consecutively enrolled study. To evaluate relationship between events occurrence (fatal non-fatal) increased CRP levels, ASDAS...
Objectives To develop an intensive training programme for ultrasound (US)-guided synovial tissue (ST) biopsy on knees and wrists in inflammatory arthritis to assess the learning curve, patient tolerability, sample quality trainees’ expectations. Methods Active or remission rheumatoid patients were enrolled. Nine trainees joined 4-month a centre experienced performing US-guided ST biopsies consisting of four sequential phases: (1) observation, (2) performance guided step-by-step phases, (3)...
Clinical remission is the main target in management of patients with rheumatoid arthritis (RA). However, several authors found synovitis RA clinical at ultrasonography (US). Upadacitinib a selective Janus kinase 1 inhibitor that achieved significantly higher rates than adalimumab and abatacept RA. Here we present 24-week data UPAdacitinib Rheumatoid Arthritis REmission UltraSonography (UPARAREMUS) study. This longitudinal multicenter observational study, enrolling bio-naïve bio-inadequate...
Non-infectious uveitis (NIU) can be an early or even the first extra-articular manifestation of systemic rheumatic diseases, one; thus, rheumatologists are often involved in diagnostic and therapeutic assessment NIU. We evaluated 130 patients with a diagnosis NIU who were admitted to two Italian rheumatologic clinics (Tor Vergata University Hospital Rome, Federico II Naples) from January 2018 December 2021. Anterior (AU) occurred 75.4% patients, followed by posterior (PU, 21.5%); acute...
The vitamin D receptor (VDR), binding to the active form of vitamin, promotes transcription numerous genes involved in proliferation immune cells, cytokine production and lymphocyte activation. It is known that deficiency can influence risk developing rheumatoid arthritis (RA) or modulate its disease activity. aim this study was investigate a possible association between rs11568820 (C > T) polymorphism promoter region VDR gene response therapy with anti-TNF drugs patients RA. A total 178...
Background: Enteropathic spondyloarthritides (eSpAs) are chronic inflammatory joint diseases associated with bowel disease (IBD). Limited data available on the prevalence since arthritis in IBD patients may be underestimated because medications hide activity a possible diagnostic delay. Objectives: We aimed to evaluate delay eSpA and explore demographic, clinical, radiographic characteristics. Design: Single-centre cross-sectional study conducted consecutive out-patients referred combined...
We aimed to identify an expression profile of lncRNAs potentially related treatment response in Psoriatic arthritis (PsA) patients, be used as potential genomic biomarkers predictors drug effectiveness. In addition, we evaluated a possible association between genetic variants and the therapy using clinical parameter Disease Activity Index. For study, collected 48 treated PsA monitoring for 12 months. initially PCR Array and, then, validated results with qRT-PCR. also retrospectively...
Background Rheumatoid Arthritis (RA) is a chronic inflammatory disease with heterogeneous treatments’ clinical response. Goals of treatment are remission and low activity, which not achieved in all patients despite the introduction early treat to target strategy. Objective To investigate causes disease-modifying antirheumatic drugs (DMARDs) discontinuation failure multiple for inefficacy, identify possible predictors’ according RA patient characteristics real-world setting. Methods 718 were...
Abstract Golimumab is a fully human monoclonal antibody against tumor necrosis factor (TNF) approved for the treatment of ulcerative colitis and not Crohn disease (CD). Many CD patients experience primary, secondary failure, or intolerance to other TNF inhibitors (TNFi) in Italy (adalimumab infliximab). Spondyloarthritis (SpA) may be associated with (enteropathic, ESpA) up 50% requiring multidisciplinary tailored approach. However, only few data from literature no formal trials determined...
The interplay between female fertility and autoimmune diseases (AIDs) can involve HLA haplotypes micronutrients. We analyzed the distribution of HLA-DQ2/-DQ8 in women with infertility or recurrent spontaneous abortion (RSA) possible associations AIDs micronutrient status. Consecutive (n = 187) RSA, controls 350) were included. All genotyped for HLA-DQ2 (DQA1*0201, A1*05, B1*02) -DQ8 (DQA1*03 DQB1*0302) alleles. Serum 25(OH)D, VB12, folate, ferritin evaluated. DQA1*05/B1*02 occurrence at...
<h3>Background:</h3> Idiopathic Inflammatory Myositis (IIM) is a rare autoimmune systemic disease characterized by wide spectrum of clinical manifestations mainly involving skin and muscles. Few data are available on literature exploring the gender differences in IIM patients. <h3>Objectives:</h3> To analyze difference patients autoantibody profiles as well treatment strategies. <h3>Methods:</h3> We performed cross sectional observational study including who fulfilled ACR/EULAR 2017 criteria...
<h3>Background:</h3> ANCA-associated vasculitides (AAVs) are characterized by small blood vessel inflammation resulting in organ damage. Evidence suggests that positivity to ANCA antibodies could affect clinical phenotype. Pulmonary involvement is frequent and variable among AAV manifestations. Radiological findings, mainly computed tomography (CT) images, represent key tools for the detection of lung involvement, including interstitial disease (ILD), nodules, tracheobronchial inflammation,...