A5101706165- Psoriasis: Treatment and Pathogenesis
- Metal complexes synthesis and properties
- Dermatology and Skin Diseases
- Pregnancy and preeclampsia studies
- Acute Myeloid Leukemia Research
- Gestational Diabetes Research and Management
- DNA and Nucleic Acid Chemistry
- Hematopoietic Stem Cell Transplantation
- Inflammatory Bowel Disease
- Autoimmune Bullous Skin Diseases
- Spondyloarthritis Studies and Treatments
- Ferrocene Chemistry and Applications
- Estrogen and related hormone effects
- Acute Lymphoblastic Leukemia research
- Biosimilars and Bioanalytical Methods
- Genetic and rare skin diseases.
- Spaceflight effects on biology
- Immune Cell Function and Interaction
- Cancer Treatment and Pharmacology
- Dermatological and COVID-19 studies
- Autoimmune and Inflammatory Disorders Research
- Chemical Reactions and Isotopes
- Birth, Development, and Health
- Medical and Biological Ozone Research
- Lung Cancer Research Studies
Azienda Ospedaliera Sant'Andrea
2018-2025
Sapienza University of Rome
2019-2025
CTO Andrea Alesini
2021-2024
World Health Organization
2021
University of Messina
2005-2019
Zero to Three
2015
University of Reggio Calabria
2010-2011
University of Modena and Reggio Emilia
2005
Sigma Tau (Italy)
2000
Centre National de la Recherche Scientifique
2000
Abstract Objective. To evaluate the ability of endoglin, placental growth factor (PlGF) and soluble form vascular endothelial receptor (sFlt‐1) measurements in gestational weeks 24–28 were used to predict pre‐eclampsia. Design. Observational, prospective study. Setting. Department Gynecological, Obstetrical Sciences Reproductive Medicine, University Messina. Sample. Fifty‐two pre‐eclamptic 52 healthy pregnant women. Methods. A maternal serum sample was frozen stored at 1‐h 50‐g glucose...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA trans-platinum complex showing higher antitumor activity than the cis congenersMauro Coluccia, Anna Nassi, Francesco Loseto, Angela Boccarelli, Maria A. Mariggio, Domenico Giordano, P. Intini, Paola Caputo, and Giovanni NatileCite this: J. Med. Chem. 1993, 36, 4, 510–512Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://doi.org/10.1021/jm00056a012RIGHTS &...
Diabet. Med. 28, 972–975 (2011) Abstract Aim To test the hypothesis that myoinositol supplementation will improve insulin sensitivity as measured by markers of resistance such homeostasis model assessment and adiponectin in women with gestational diabetes. Methods The trial was carried out diet‐treated patients diabetes diagnosed our department between April 2008 September 2009. Subjects were randomly assigned to receive either (4 g daily) plus folic acid (400 μg daily)—the study group—or...
The aim of this study was to evaluate whether myo-inositol, an insulin-sensitizing substance, may improve some features metabolic syndrome in postmenopausal women.Eighty women affected by the were enrolled prospectively and treated with diet plus supplementation myo-inositol (2 g BID diet: intervention group) or placebo (control for 6 months. They evaluated at baseline after months insulin resistance (homeostasis model assessment ratio [HOMA] resistance), lipid profile, blood...
Objective To evaluate the 12-month effect of myo-inositol treatment on some biochemical parameters women affected by metabolic syndrome.Methods Eighty outpatient postmenopausal women, syndrome, were enrolled in a study. All treated with low-energy diet, and then they randomly assigned to 2 g b.i.d. (n = 40) or placebo 40). evaluated for serum glucose, insulin, HOMA-IR (Homeostasis Model Assessment-Insulin Resistance), triglycerides, total high density lipoprotein cholesterol, body mass index...
Several new biologic agents targeting IL23/Th17 axis, such as risankizumab, have been developed for the treatment of psoriasis. The aim present study was to analyze efficacy and safety risankizumab in patients with moderate-to-severe psoriasis over a 52-week period. A multicentric retrospective conducted who initiated between July 2019 December 2020. Psoriasis Area Severity Index-PASI measured at baseline after 4, 16, 28 52 weeks. Clinical responses were evaluated by PASI75, PASI90 PASI100...
Background/Objectives: Psoriasis is a chronic inflammatory skin disease that may have significant impact on patients’ quality of life. Alongside clinical scores, treatment goals include improvements in life, divided into its social, working and psychosocial life aspects. Indeed, psychological impairment should always be considered the management moderate-to-severe psoriasis. Tildrakizumab, an anti-IL-23, approved for Both trials real-life studies show efficacy safety; however, no evaluated...
Introduction: Risankizumab and secukinumab are effective treatment options for patients with moderate to severe psoriasis. Objective: We sought estimate the efficacy cost per responder of risankizumab by comparing these two drugs in a real-life setting. Methods:.A multicentric retrospective study was conducted from Lazio region Italy affected moderate-to-severe psoriasis who initiated or between September 2020 2022. Psoriasis Area Severity Index (PASI) measured at baseline after 16, 52, 78...
Biologic drugs have revolutionized the treatment of psoriasis and other chronic inflammatory diseases. In recent years, numerous biosimilar molecules that target cytokines such as TNF-alpha or its receptors been developed. The approval biosimilars has made it possible to reduce costs biologic drugs, thereby increasing access these therapies for more patients enhancing globally. Imraldi Idacio are both Adalimumab, approved treating moderate severe psoriasis. Our study aims compare two...
Adiponectin is an exclusively adipose tissue-derived protein. Low plasma adiponectin levels have been found in hypertensive men. Our objective was to evaluate whether low first-trimester values were predictive of disorders later pregnancy.A nested case-control study carried out on a cohort 1,842 pregnant women who participated the Down syndrome screening program; 34 developed preeclampsia and 48 gestational hypertension. A control group 82 nonhypertensive uneventful pregnancies selected....
To investigate the modifications of antitumor activity and DNA binding mode transplatin after replacement one nonleaving group NH<sub>3</sub> by an iminoether group,<i>trans</i>-[PtCl<sub>2</sub>{<i>Z</i>-HN=C(OMe)Me}(NH<sub>3</sub>)] and<i>trans</i>-[PtCl<sub>2</sub>{<i>E</i>-HN=C(OMe)Me}(NH<sub>3</sub>)] complexes (differing in <i>Z</i> or <i>E</i>configuration iminoether, abbreviated mixed <i>E</i>, respectively), have been synthesized. In a panel human tumor cell lines, both <i>E</i>...
Abstract Background IL‐23 inhibitors were recently approved for the treatment of skin psoriasis and psoriatic arthritis (PsA). Risankizumab, a humanized monoclonal antibody that specifically binds p19 subunit IL‐23, has proven effective on PsA in two randomized controlled trials. To date, only few real‐world data are available this topic. Methods Our study aimed to prospectively evaluate effectiveness risankizumab patients with setting. For purpose, both rheumatologic dermatologic...
S ummary . A to O bone marrow transplantation was performed in a 25‐year‐old male affected with severe aplastic anaemia, the donor being an HLA compatible brother. Three plasma exchanges had be Aminco separator remove original and recurring anti‐A isohaemagglutinins. The dynamics of blood group conversion were followed by means differential agglutination. An early wave marked dyserythropoiesis observed engrafted marrow. Mild moderate GvHD treated successfully MTX, bolus high dosage...
To evaluate which pregnant women with a single abnormal value in the oral glucose tolerance test are at increased risk for adverse perinatal outcome.In this retrospective cohort study, we have evaluated course of pregnancy 152 consecutive only one (OAV), and 624 100 g - totally within range values.The prevalence caesarean delivery, hypertensive disorders macrosomia was higher study group when compared control group, whereas no difference noted concerning gestational age Apgar score 1 5 min...
This was an observational, retrospective, multicenter study, enrolling elderly patients (>65 years old) treated with ixekizumab a diagnosis of psoriasis (PsO) and/or psoriatic arthritis (PsA) during the period 2020 to 2023.
Background: the present multicenter retrospective study aimed to evaluate efficacy and safety of intra-class switching between interleukin-17A (IL-17A) inhibitors, specifically from ixekizumab secukinumab, in patients with plaque psoriasis. Methods: this included 11 (6 male, 5 female) who had previously received then were switched secukinumab. Patients’ PASI, DLQI, pain VAS (in those psoriatic arthritis) evaluated at weeks 16, 24, 54, 98. Results: PASI-90 was reached 10 (91%) cases week 24....
Abstract: Endometrial hyperplasia without cytological atypia is commonly treated with progestins, but other treatments may be available equivalent efficacy and reduced side effects. Here, we evaluate the effect of genistein aglycone on angiogenesis apoptosis-related markers women endometrial hyperplasia. Premenopausals (n=38) nonatypical were administered either (54 mg/day, n=19) or norethisterone acetate (10 days 16–25 menstrual cycle evaluated for 6 months. Biopsies taken during...