A5014523351- Phytoestrogen effects and research
- Adenosine and Purinergic Signaling
- Estrogen and related hormone effects
- Systemic Sclerosis and Related Diseases
- Wound Healing and Treatments
- Bone health and osteoporosis research
- Exercise and Physiological Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Heavy Metal Exposure and Toxicity
- Regulation of Appetite and Obesity
- Muscle Physiology and Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- melanin and skin pigmentation
- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Growth Hormone and Insulin-like Growth Factors
- Neuropeptides and Animal Physiology
- Peptidase Inhibition and Analysis
- Sirtuins and Resveratrol in Medicine
- Effects and risks of endocrine disrupting chemicals
- Diabetic Foot Ulcer Assessment and Management
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Cancer Risks and Factors
- Ubiquitin and proteasome pathways
University of Messina
2016-2025
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2007-2020
The Royal Free Hospital
2018
University College London
2018
Institute of Pharmacology
2004-2017
Zero to Three
2015
Fatebenefratelli Hospital
2014
Azienda Sanitaria Locale Alessandria
2014
University of Louisville Hospital
2013
University of Modena and Reggio Emilia
2008-2010
Background: Observational studies and small trials of short duration suggest that the isoflavone phytoestrogen genistein reduces bone loss, but evidence is not definitive. Objective: To assess effects on metabolism in osteopenic postmenopausal women. Design: Randomized, double-blind, placebo-controlled trial. Setting: 3 university medical centers Italy. Patients: 389 women with a mineral density (BMD) less than 0.795 g/cm2 at femoral neck no significant comorbid conditions. Intervention:...
Context: Genistein, a soy isoflavone, has received wide attention over the last few years because of its potential preventive role for cardiovascular disease.
Genistein aglycone improves bone metabolism in women. However, questions about the long-term safety of genistein on breast as well its continued efficacy still remain.We assessed profile and endometrium effects after 3 yr therapy.The parent study was a randomized, double-blind, placebo-controlled trial involving 389 osteopenic, postmenopausal women for 24-months. Subsequently, subcohort (138 patients) therapy an additional year.Participants received 54 mg daily (n = 71) or placebo 67). Both...
This study was performed to evaluate the effects of genistein on metabolic and cardiovascular risk factors in Caucasian postmenopausal subjects with syndrome (MetS). Our objective assess surrogate endpoints associated diabetes disease. a randomized, double-blind, placebo-controlled trial at 3 university medical centers Italy. Patients included 120 women MetS according modified Third Report National Cholesterol Education Program (NCEP), Expert Panel Detection, Evaluation Treatment High Blood...
Healing of diabetic wounds still remains a critical medical problem. Polydeoxyribonucleotide (PDRN), compound having mixture deoxyribonucleotide polymers, stimulates the A2 purinergic receptor with no toxic or adverse effect. We studied effects PDRN in diabetes-related healing defect using an incisional skin-wound model produced on back female mice (db+/db+) and their normal littermates (db+/+m). Animals were treated daily for 12 days (8 mg/kg/ip) its vehicle (100 muL 0.9%NaCl). Mice killed...
BAY 11-7082 antagonizes I-κB kinase-β preventing nuclear translocation of factor-κB (NF-κB); it also inhibits NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation. NF-κB is involved in psoriasis, whereas the role NLRP3 controversial. We investigated effects an experimental model psoriasis-like dermatitis. Psoriasis-like lesions were induced by a topical application imiquimod (IMQ) cream (62.5 mg/day) on shaved back skin C57BL/6 and knockout (KO) mice for 7...
Treatment for traumatic brain injury (TBI) remains elusive despite compelling evidence from animal models a variety of therapeutic targets. The activation the NLRP3 (Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3) inflammasome has been proposed as key point in damage associated with TBI. was tested potential target reducing neuronal loss and promoting functional recovery mouse model Male NLRP3-/- (n = 20) wild type 27) mice were used. A closed TBI...
Cardiac fibrosis is a pathological process characterized by an excessive deposition of extracellular matrix (ECM) and increased production fibrillar collagen in the cardiac interstitium, mainly caused activation fibroblasts their transition into myofibroblasts. Oxidative stress deeply implicated pathogenesis both directly via its involvement tumor growth factor β1 (TGF-β1) signaling. Ellagic acid (EA) punicic (PA) are main components Punica granatum L (pomegranate) fruit seed oil...
The effects of recombinant human erythropoietin (rHuEPO) in diabetes-related healing defects were investigated by using an incisional skin-wound model produced on the back female diabetic C57BL/KsJ-m(+/+)Lept(db) mice (db(+)/db(+)) and their normoglycemic littermates (db(+/+)m). Animals treated with rHuEPO (400 units/kg 100 microl s.c.) or its vehicle alone (100 microl). Mice killed different days (3, 6, 12 after skin injury) for measurement vascular endothelial growth factor (VEGF) mRNA...
Objective: A vagus nerve–mediated, brain cholinergic protective mechanism activated by melanocortin peptides is operative in conditions of circulatory shock; moreover, there anatomical evidence dual vagal-cardiac efferent pathways rats, which could play different roles controlling heart function. Therefore, we investigated the role and functional such vagal pathway(s) an experimental model ischemic disease. Design: Randomized study. Setting: Research laboratory. Subjects: Adult Wistar rats...
In Brief Objective: We evaluated and compared the effects of phytoestrogen genistein, estrogen-progestogen therapy (EPT), placebo on hot flushes endometrial thickness in postmenopausal women. Design: Ninety healthy, women, 47 to 57 years age, were randomly assigned receive for 1 year continuous EPT (n = 30; mg 17β-estradiol combined with 0.5 norethisterone acetate), genistein 54 mg/day), or 30). Endometrial safety was by intravaginal ultrasounds at baseline, 6 12 months. Results: By...
The area of Milazzo-Valle del Mela (Sicily, Italy) is considered at high risk environmental crisis by regional authorities. To measure oxidative-stress, DNA repair and detoxification genes in school children living near the industrial age-matched controls. parent study was a biomonitoring investigation evaluating heavy metal urine levels 226 aged 12–14 years, area, 29 controls 45 km far from site. In present 67 exposed adolescents were included. Samples analyzed for urinary...
Broad antiinflammatory effects following adenosine A(₂A) receptor stimulation have been demonstrated in acute inflammatory diseases, including arthritis. Polydeoxyribonucleotide (PDRN) activates the receptor. This study was undertaken to investigate of PDRN collagen-induced arthritis (CIA) mice.Arthritis induced DBA/1 mice by an intradermal injection 100 μl bovine type II collagen Freund's complete adjuvant. Mice were immunized a second time 21 days later. Control animals received saline...
Type 2 diabetes impairs the healing process because of an exaggerated and persistent inflammatory response, altered expression pattern angiogenic molecules. We investigated effects inflammasome blockade in diabetes-related wound-healings defects, genetically diabetic mice.An incisional skin wound model was produced on back female C57BL/KsJ-m +/+ Lept(db) mice (db⁺ /db⁺) their normal littermates /m⁺). Animals were treated daily with two blocking agents, BAY 11-7082 (20 mg·kg⁻¹ i.p.), or...
Experimental evidence suggests that cadmium (Cd) boosts oxidative stress may result in toxicity on the endocrine system also humans. The aim of this study was to investigate glycemic control and markers male adolescents with increased urinary levels cadmium. We investigated 111 males, aged 12–14 years, living a polluted area Sicily age‐matched population ( n = 60) 28–45 km far from site. Malondialdehyde (MDA), total antioxidant activity (TAC), metallothionein‐1A (MT‐1A) gene expression,...