A5085164024- Heavy Metal Exposure and Toxicity
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- Inflammation biomarkers and pathways
- Toxic Organic Pollutants Impact
- Circular RNAs in diseases
- Wound Healing and Treatments
- Glycosylation and Glycoproteins Research
- Sports and Physical Education Research
- Peptidase Inhibition and Analysis
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Crystallization and Solubility Studies
- Immune Response and Inflammation
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
- Pressure Ulcer Prevention and Management
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Estrogen and related hormone effects
- Bone health and treatments
- Diabetic Foot Ulcer Assessment and Management
University of Messina
2017-2025
Experimental evidence suggests that cadmium (Cd) boosts oxidative stress may result in toxicity on the endocrine system also humans. The aim of this study was to investigate glycemic control and markers male adolescents with increased urinary levels cadmium. We investigated 111 males, aged 12–14 years, living a polluted area Sicily age‐matched population ( n = 60) 28–45 km far from site. Malondialdehyde (MDA), total antioxidant activity (TAC), metallothionein‐1A (MT‐1A) gene expression,...
Endocan is a circulating proteoglycan secreted by several cell lines and identified as potential biomarker of inflammation angiogenesis. Endocan-increased expression has been found in broad spectrum human tumors, including lung cancer, associated with poor prognosis. To elucidate the possible mechanism, this study aimed to investigate role endocan non-small-cell carcinoma (NSCLC) using an vitro model cultured cells. was knocked down specific small interfering RNA. The effects knockdown have...
Glucocorticoid-induced osteoporosis (GIO) is a secondary cause of bone loss. Bisphosphonates approved for GIO, might induce jaw osteonecrosis; thus additional therapeutics are required. Adenosine receptor agonists positive regulators remodeling, the efficacy adenosine stimulation treating GIO was tested. In preventive study induced in Sprague-Dawley rats by methylprednisolone (MP) 60 days. Animals were randomly assigned to receive polydeoxyribonucleotide (PDRN), an A2 agonist, or PDRN and...
Pituitary adenomas (PAs), usually benign lesions, can sometimes present with "aggressive" features (rapid growth, local invasiveness, scarce response to conventional treatments). Despite the fact that a few genetic alterations have been associated this clinical behavior, role of epigenetic modifications, mainly methylation and miRNAs activity, is now opening new frontiers in field. We evaluated profile 21 PA (11 GH-omas, 10 nonfunctioning tumors-NFPAs) samples from TNS surgery 5 normal...
Endocan is a small soluble proteoglycan (PG) known to be involved in inflammation and angiogenesis. Increased endocan expression was found the synovia of arthritic patients chondrocytes stimulated with IL-1ß. Considering these findings, we aimed investigate effects knockdown on modulation pro-angiogenic molecules model IL-1ß-induced human articular chondrocytes. Endocan, VEGF-A, MMP-9, MMP-13, VEGFR-2 measured both normal NF-kB activation were also measured. Results have shown that endocan,...
Cadmium (Cd) is a potentially toxic element able to interfere with cellular functions and lead disease or even death. Cd accumulation has been demonstrated in cartilage, where it can induce damage joints. The aim of this study was evaluate the effect CdCl2 on primary cultures human chondrocytes possible protective seleno-methionine (Se-Met). Human articular were cultured treated as follows: control groups, cells challenged 7.5 μM 10 alone, pretreated 20 Se-Met then CdCl2. Twenty-four hours...
Inflammation is the body's response to injuries, which depends on numerous regulatory factors. Among them, miRNAs have gained much attention for their role in regulating inflammatory gene expression at multiple levels. In particular, miR-21 up-regulated during and reported be involved resolution of inflammation by down-regulating pro-inflammatory mediators, including MyD88. Herein, we evaluated effects TLR-4/MyD88 pathway an vitro model 6-mer HA oligosaccharides-induced human chondrocytes....
Post-operative cognitive dysfunction (POCD) refers to the functional impairment of nervous system caused by prolonged exposure anesthetics. It is known that anesthetics may increase risk for development several impairments. The drugs used induce general anesthesia are generally safe, owing CNS's direct and/or indirect self-protective activity against drug-induced damages. Non-coding RNAs have recently started gain attention better understand mechanism gene regulation correlated cellular...