A5068043961- Autoimmune Bullous Skin Diseases
- Metabolism and Genetic Disorders
- Dermatological and Skeletal Disorders
- Cutaneous lymphoproliferative disorders research
- Skin and Cellular Biology Research
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Corneal surgery and disorders
- Congenital Heart Disease Studies
- Cancer and Skin Lesions
- Connective tissue disorders research
- Genetic and rare skin diseases.
- Eosinophilic Disorders and Syndromes
- Urticaria and Related Conditions
- Nail Diseases and Treatments
- Genomic variations and chromosomal abnormalities
- Skin Protection and Aging
- Chemotherapy-related skin toxicity
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Skin Diseases and Diabetes
- Autoimmune and Inflammatory Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- RNA regulation and disease
University of Messina
2016-2025
University of Trieste
2021
University of Catania
2019
Policlinico Universitario di Catania
1996-2017
Institute of Dermatology
2002-2013
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2008
Institutes of Science and Development
2008
University of Genoa
2002
GTx (United States)
1997-1998
BAY 11-7082 antagonizes I-κB kinase-β preventing nuclear translocation of factor-κB (NF-κB); it also inhibits NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation. NF-κB is involved in psoriasis, whereas the role NLRP3 controversial. We investigated effects an experimental model psoriasis-like dermatitis. Psoriasis-like lesions were induced by a topical application imiquimod (IMQ) cream (62.5 mg/day) on shaved back skin C57BL/6 and knockout (KO) mice for 7...
β-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that tempers inflammation. An interaction between the CB2 and peroxisome proliferator-activated gamma (PPAR-γ) has been suggested PPAR-γ activation exerts anti-arthritic effects. The aim of this study was to characterize therapeutic activity BCP investigate involvement in collagen antibody induced arthritis (CAIA) experimental model. CAIA through intraperitoneal injection monoclonal cocktail lipopolysaccharide (LPS; 50 μg/100...
Glioblastomas are aggressive cancers characterized by uncontrolled proliferation and inflammation. b-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that showed an important anti-inflammatory effect through the interaction of CB2 peroxisome proliferator-activated gamma (PPARg) receptors. BCP effects were investigated in vitro model glioblastoma. U-373 U87, derived from human glioblastoma, glioma stem-like cells (GSCs) treated with at different doses time-points. AM360, specific...
Immuno-correlated dermatological pathologies refer to skin disorders that are closely associated with immune system dysfunction or abnormal responses. Advancements in the field of artificial intelligence (AI) have shown promise enhancing diagnosis, management, and assessment immuno-correlated pathologies. This intersection dermatology immunology plays a pivotal role comprehending addressing complex involvement. The paper explores knowledge known so far evolution achievements AI diagnosis;...
Background and Objectives: Tirbanibulin 1% ointment is a novel synthetic anti-proliferative agent that inhibits tubulin polymerization. It approved for treating actinic keratosis (AK) on the face scalp in adults. has demonstrated good efficacy, an adequate safety profile excellent patient adherence phase 3 clinical trials, however data about its real-life efficacy are lacking. Here we report experience of dermatology unit University Hospital Messina. Materials Methods: We performed...
Many studies demonstrate increased androgen levels and high prevalence of polycystic ovaries in women affected by acne.We evaluated the relationship between clinical features, ultrasonographic data on hormonal parameters 129 w17 years age with acne.Serum androgens ovarian adrenal origin were measured.Menstrual cycle regularity, hirsutism, body mass index evaluation recorded.Raised at least one evident a majority our patients.Only 19% them had ovary syndrome.Hirsutism acne severity correlated...
Ovariectomy accelerates age-related skin changes as adequate oestrogen levels are required to control structural integrity and functional capacity of skin. Genistein, a soy-derived isoflavone, has been tested in anti-ageing cosmetic preparations with interesting results on elasticity, photoaging cancer prevention. We investigated the effects genistein aglycone compared them systemic raloxifene hydrochloride 17-α-ethinyloestradiol aged, ovariectomized (OVX) rats.Six months after ovariectomy,...
Foot ulcer is the principal cause of hospitalization for patients with diabetes. Polydeoxyribonucleotide (PDRN), an adenosine A2A receptor agonist, improves wound healing in diabetic mice.The aim this study was to evaluate effect PDRN on chronic diabetes.This randomized, double-blind, placebo-controlled trial, involved two medical centers Italy.Patients diabetes showing hard-to-heal ulcers (Wagner grade 1 or 2) were randomly assigned receive placebo (n = 106) 110). The treatments (PDRN and...
Human gingival fibroblasts (GF) and human oral mucosa epithelial cells (EC) with an inflammatory phenotype represent a valuable experimental paradigm to explore the curative activity of agents be used in mucositis. The role cannabinoid receptor 2 (CB2) has not yet been investigated aim this study was evaluate therapeutic potential β-Caryophyllene (BCP), CB2 agonist, vitro model GF EC were stimulated LPS (2 µg/mL) alone or combination BCP; group challenged treated BCP AM630, antagonist....