A5046662292- Phytoestrogen effects and research
- Heavy Metal Exposure and Toxicity
- Estrogen and related hormone effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Urinary Bladder and Prostate Research
- Bone health and osteoporosis research
- Hormonal and reproductive studies
- Sperm and Testicular Function
- Trace Elements in Health
- Neuroscience and Neuropharmacology Research
- Wound Healing and Treatments
- Vagus Nerve Stimulation Research
- Antioxidant Activity and Oxidative Stress
- Selenium in Biological Systems
- Diet, Metabolism, and Disease
- Adenosine and Purinergic Signaling
- Cancer Risks and Factors
- Olfactory and Sensory Function Studies
- Anesthesia and Neurotoxicity Research
- Angiogenesis and VEGF in Cancer
- Neuropeptides and Animal Physiology
- Fatty Acid Research and Health
- Bone Metabolism and Diseases
- Vitamin C and Antioxidants Research
- Virus-based gene therapy research
University of Messina
2016-2025
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2003-2016
National Institutes of Health
2005-2006
National Institute of Neurological Disorders and Stroke
2005
Institute of Pharmacology
2004
University of Modena and Reggio Emilia
2003
International Centre for Genetic Engineering and Biotechnology
2003
Background: Observational studies and small trials of short duration suggest that the isoflavone phytoestrogen genistein reduces bone loss, but evidence is not definitive. Objective: To assess effects on metabolism in osteopenic postmenopausal women. Design: Randomized, double-blind, placebo-controlled trial. Setting: 3 university medical centers Italy. Patients: 389 women with a mineral density (BMD) less than 0.795 g/cm2 at femoral neck no significant comorbid conditions. Intervention:...
Background— We investigated whether electrical stimulation (STIM) of efferent vagus nerves may suppress nuclear factor (NF)-κB activation and the inflammatory cascade in hemorrhagic (Hem) shock. Methods Results— Rats were subjected to bilateral cervical vagotomy (VGX) or sham surgical procedures. Hem shock was induced by intermittent withdrawing blood until mean arterial pressure stabilized within range 35 40 mm Hg. Application constant voltage pulses caudal ends (STIM; 5 V, 2 ms, 1 Hz for...
Context: Genistein, a soy isoflavone, has received wide attention over the last few years because of its potential preventive role for cardiovascular disease.
Genistein aglycone improves bone metabolism in women. However, questions about the long-term safety of genistein on breast as well its continued efficacy still remain.We assessed profile and endometrium effects after 3 yr therapy.The parent study was a randomized, double-blind, placebo-controlled trial involving 389 osteopenic, postmenopausal women for 24-months. Subsequently, subcohort (138 patients) therapy an additional year.Participants received 54 mg daily (n = 71) or placebo 67). Both...
This study was performed to evaluate the effects of genistein on metabolic and cardiovascular risk factors in Caucasian postmenopausal subjects with syndrome (MetS). Our objective assess surrogate endpoints associated diabetes disease. a randomized, double-blind, placebo-controlled trial at 3 university medical centers Italy. Patients included 120 women MetS according modified Third Report National Cholesterol Education Program (NCEP), Expert Panel Detection, Evaluation Treatment High Blood...
The effects of recombinant human erythropoietin (rHuEPO) in diabetes-related healing defects were investigated by using an incisional skin-wound model produced on the back female diabetic C57BL/KsJ-m(+/+)Lept(db) mice (db(+)/db(+)) and their normoglycemic littermates (db(+/+)m). Animals treated with rHuEPO (400 units/kg 100 microl s.c.) or its vehicle alone (100 microl). Mice killed different days (3, 6, 12 after skin injury) for measurement vascular endothelial growth factor (VEGF) mRNA...
Objective: A vagus nerve–mediated, brain cholinergic protective mechanism activated by melanocortin peptides is operative in conditions of circulatory shock; moreover, there anatomical evidence dual vagal-cardiac efferent pathways rats, which could play different roles controlling heart function. Therefore, we investigated the role and functional such vagal pathway(s) an experimental model ischemic disease. Design: Randomized study. Setting: Research laboratory. Subjects: Adult Wistar rats...
In Brief Objective: We evaluated and compared the effects of phytoestrogen genistein, estrogen-progestogen therapy (EPT), placebo on hot flushes endometrial thickness in postmenopausal women. Design: Ninety healthy, women, 47 to 57 years age, were randomly assigned receive for 1 year continuous EPT (n = 30; mg 17β-estradiol combined with 0.5 norethisterone acetate), genistein 54 mg/day), or 30). Endometrial safety was by intravaginal ultrasounds at baseline, 6 12 months. Results: By...
Broad antiinflammatory effects following adenosine A(₂A) receptor stimulation have been demonstrated in acute inflammatory diseases, including arthritis. Polydeoxyribonucleotide (PDRN) activates the receptor. This study was undertaken to investigate of PDRN collagen-induced arthritis (CIA) mice.Arthritis induced DBA/1 mice by an intradermal injection 100 μl bovine type II collagen Freund's complete adjuvant. Mice were immunized a second time 21 days later. Control animals received saline...
Ischemic stroke is one of the main causes death and disability. We investigated whether melanocortin peptides, which have protective effects in severe hypoxic conditions, also produce neuroprotection a gerbil model ischemic stroke. A 10-min period global cerebral ischemia, induced by occluding both common carotid arteries, caused impairment spatial learning memory that was associated with activation inflammatory apoptotic pathways, including DNA damage delayed neuronal death, hippocampus....
Men with epilepsy often have sexual or reproductive abnormalities that are attributed to alterations in androgen levels, including subnormal free testosterone. Levels of the major metabolites testosterone-androsterone (5alpha-androstan-3alpha-ol-17-one; 5alpha,3alpha-A), a neurosteroid acts as positive allosteric modulator GABA(A) receptors, and its 5beta-epimer etiocholanolone (5beta-androstan-3alpha-ol-17-one; 5beta,3alpha-A)-also may be reduced epilepsy. 5alpha,3alpha-A has been found...
Background and purpose: Genistein aglycone positively affects bone loss in postmenopausal women, but quality data are still lacking. To clarify this, we investigated the effects of genistein compared with alendronate, raloxifene oestradiol an animal model established osteoporosis. Experimental approach: Six months after ovariectomy, 96 ovariectomized (OVX) rats were divided into 8 equal groups, randomized to treatments (genistein (1 10 mg kg −1 s.c.); alendronate (0.003 0.03 hydrochloride...
To evaluate in a 12-month, prospective, randomized, double-blind, placebo-controlled study whether pure administration of the phytoestrogen genistein (54 mg/d) might reduce number and severity hot flushes postmenopausal women with no adverse effect on endometrium.A total 389 participants met main criteria were randomly assigned to receive (n=198) or placebo (n=191). About 40% both groups did not suffer from flushes, evaluation was performed subgroup 247 (genistein, n=125; placebo, n=122)....
In Brief Objective: To evaluate in a 24-month, prospective, randomized, double-blind, placebo-controlled study whether pure administration of the phytoestrogen genistein (54 mg/d) might reduce number and severity hot flushes postmenopausal women, with no adverse effect on endometrium vagina. Methods: A total 389 participants met parent criteria were randomly assigned to receive (n = 198) or placebo 191). About 40% both groups did not experience flushes, evaluation was performed subgroup 236...
Abstract Introduction: RANKL and its decoy receptor osteoprotegerin (OPG) constitute a complex physiological mediator system involved in the regulation of bone resorption may be responsible for homeostatic mechanism normal remodeling. Genistein, an isoflavone representing 1–5% total phytoestrogen content soybean products, positively regulate cellular metabolism, but action on is not yet fully understood. Materials Methods: We studied serum levels both soluble (sRANKL) OPG sRANKL/OPG ratio...