A5058362315- Wound Healing and Treatments
- Orthopedic Surgery and Rehabilitation
- Peripheral Nerve Disorders
- Nerve Injury and Rehabilitation
- Reconstructive Surgery and Microvascular Techniques
- Nerve injury and regeneration
- Musculoskeletal synovial abnormalities and treatments
- Erythropoietin and Anemia Treatment
- Immune Response and Inflammation
- Virus-based gene therapy research
- Angiogenesis and VEGF in Cancer
- Mesenchymal stem cell research
- Elbow and Forearm Trauma Treatment
- Phytochemicals and Antioxidant Activities
- Hemoglobinopathies and Related Disorders
- Skin Protection and Aging
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Cancer and Skin Lesions
- Adenosine and Purinergic Signaling
- Nonmelanoma Skin Cancer Studies
- Advanced Glycation End Products research
- NF-κB Signaling Pathways
- Bee Products Chemical Analysis
- Pomegranate: compositions and health benefits
University of Messina
2010-2024
Istituto Ortopedico Gaetano Pini
2021-2024
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2003-2022
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2021
Azienda Ospedaliero-Universitaria Careggi
2007
United States Department of Agriculture
2004
International Centre for Genetic Engineering and Biotechnology
2003
Interventi Geo Ambientali (Italy)
2002
Impaired wound healing is a well-documented phenomenon in experimental and clinical diabetes. Experimental evidence suggests that defect vascular endothelial growth factor (VEGF) regulation might be associated with wound-healing disorders. We studied the involvement of lipid peroxidation pathogenesis altered VEGF expression diabetes-related deficit by using an incisional skin-wound model produced on back female diabetic C57BL/KsJ db+/db+ mice their normal (db+/+m) littermates. Animals were...
Healing of diabetic wounds still remains a critical medical problem. Polydeoxyribonucleotide (PDRN), compound having mixture deoxyribonucleotide polymers, stimulates the A2 purinergic receptor with no toxic or adverse effect. We studied effects PDRN in diabetes-related healing defect using an incisional skin-wound model produced on back female mice (db+/db+) and their normal littermates (db+/+m). Animals were treated daily for 12 days (8 mg/kg/ip) its vehicle (100 muL 0.9%NaCl). Mice killed...
The effects of recombinant human erythropoietin (rHuEPO) in diabetes-related healing defects were investigated by using an incisional skin-wound model produced on the back female diabetic C57BL/KsJ-m(+/+)Lept(db) mice (db(+)/db(+)) and their normoglycemic littermates (db(+/+)m). Animals treated with rHuEPO (400 units/kg 100 microl s.c.) or its vehicle alone (100 microl). Mice killed different days (3, 6, 12 after skin injury) for measurement vascular endothelial growth factor (VEGF) mRNA...
Wound healing in ischemic tissues such as flap margins due to inadequate blood supply is still a source of considerable morbidity surgical practice. Adequate tissue perfusion particularly important wound healing. We investigated the effects recombinant human erythropoietin (rHuEPO) on an skin model. Sixty-three Sprague-Dawley rats were used. Normal incisional and H-shaped double flaps used models. Animals treated with rHuEPO (400 IU/kg) or its vehicle. Rats killed different days (3, 5, 10...
Abstract Background Peripheral nerve injuries (PNIs) include several conditions in which one or more peripheral nerves are damaged. Trauma is of the most common causes PNIs and young people particularly affected. They have a significant impact on patients’ quality life healthcare system, while timing type surgical treatment utmost importance to guarantee favorable functional recovery. To date, different classifications been proposed, them focusing just few aspects these complex conditions,...
Objective: Polydeoxyribonucleotide contains a mixture of nucleotides and interacts with adenosine receptors, stimulating vascular endothelial growth factor expression wound healing. The purpose this study was to investigate the effect polydeoxyribonucleotide on experimental burn wounds. Design: Randomized experiment. Setting: Research laboratory at university hospital. Subjects: Thermal injury in mice. Interventions: Mice were immersed 80°C water for 10 secs achieve deep-dermal second-degree...
: Neuroma formation is a major problem in nerve surgery and consensus about its prevention has not been reached. It suggested that vein covering can reduce neuroma transected nerves. In this article, the Authors propose an easy novel method of by stump capping with free graft.: Neuroma-like lesions were created on rat thigh sectioning femoral above division 16 animals. The proximal was invaginated into lumen 1.5 cm long graft right side, closed itself microsurgical sutures to form cap for...
Objective The purpose of this study was to investigate the effect recombinant adeno-associated viral (rAAV) vector-mediated human vascular endothelial growth factor (VEGF165) transfer on experimental burn wounds. Design Randomized experiment. Setting Research laboratory. Subjects C57BL/6 male mice weighing 25–30 g. Interventions Mice were immersed in 80°C water for 10 secs achieve a partial-thickness scald burn. Animals randomized receive at two injection sites edge either 1011 copies...
We investigated the effects of raxofelast, a lipid peroxidation inhibitor, in an experimental model burn wounds. C57BL/6 male mice 25-30 g were immersed 80 degrees C water for 10 seconds to achieve partial-thickness scald burn. Animals received intraperitoneally either raxofelast (20 mg/kg/day 14 days 100 microL) or its vehicle alone (100 microL/day days). On day 14, areas used measuring conjugated dienes, reduced glutathione levels, histological damage, neoangiogenesis by...
Reconstruction of distal thumb injuries still remains a challenge for hand surgeons. Surgical treatment includes the use local, regional, and free flaps. The purpose this report is to present results sensitive reverse flow first dorsal metacarpal artery (FDMA) flap. skin flap was designed on radial side proximal phalanx index finger based ulnar branch FDMA sensory superficial nerve. This neurovascular used in five patients cover soft-tissue defects. All flaps achieved primary healing except...