A5006446931- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Peripheral Nerve Disorders
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Axon Guidance and Neuronal Signaling
- Tendon Structure and Treatment
- Graphene and Nanomaterials Applications
- Reconstructive Surgery and Microvascular Techniques
- Spinal Cord Injury Research
- Anesthesia and Neurotoxicity Research
- Bone Tissue Engineering Materials
- Pain Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Spine and Intervertebral Disc Pathology
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- HER2/EGFR in Cancer Research
- Muscle activation and electromyography studies
- Laser Applications in Dentistry and Medicine
- Muscle Physiology and Disorders
- Cardiac Ischemia and Reperfusion
Neuroscience Institute
2016-2025
University of Turin
2016-2025
Ospedale San Luigi Gonzaga
2005-2023
Universidad Complutense de Madrid
2022
University of Catania
2021
Torino e-district
2019
University of Trás-os-Montes and Alto Douro
2018-2019
Centro de Estudos da Voz
2019
Association for the Development of Douro Viticulture
2002-2019
University Medical Center Hamburg-Eppendorf
2017
Peripheral nerve researchers frequently use the rat sciatic crush as a model for axonotmesis. Unfortunately, studies from various research groups report results different techniques and by using variety of evaluation tools, making comparisons between difficult. The purpose this investigation was to determine sequence functional morphologic changes after an acute injury with non-serrated clamp, giving final standardized pressure p = 9 MPa. Functional recovery evaluated index (SFI), extensor...
Cachexia is a wasting syndrome associated with cancer, AIDS, multiple sclerosis, and several other disease states. It characterized by weight loss, fatigue, loss of appetite, skeletal muscle atrophy poor patient prognosis, making it an important treatment target. Ghrelin peptide hormone that stimulates growth (GH) release positive energy balance through binding to the receptor GHSR-1a. Only acylated ghrelin (AG), but not unacylated form (UnAG), can bind GHSR-1a; however, UnAG AG share...
Diabetic cardiomyopathy is characterized by myocyte loss and myocardial fibrosis, leading to decreased elasticity impaired contractile function. The study examines the downstream signaling whereby oxidative stress, induced hyperglycemia, leads fibrosis function in left ventricle of diabetic rats. It also effects dehydroepiandrosterone (DHEA), which prevents damage hyperglycemia experimental models. DHEA was administered for 6 wk diet [0.02%, wt/wt)] rats with streptozotocin-induced diabetes....
Biosynthetic nerve grafts are developed in order to complement or replace autologous for peripheral reconstruction. Artificial guides currently approved clinical use not widely applied reconstructive surgery as they still have limitations especially when it comes critical distance repair. Here we report a comprehensive analysis of fine-tuned chitosan (CNGs) enhanced by introduction longitudinal film reconstruct length 15 mm sciatic defects adult healthy Wistar diabetic Goto-Kakizaki rats....
Biosynthetic nerve grafts are desired as alternative to autologous in peripheral reconstruction.Artificial conduits still have their limitations and not widely accepted the clinical setting.Here we report an analysis of fine-tuned chitosan tubes used reconstruct 10 mm defects adult rat.The displayed low, medium high degrees acetylation (DAI: w2%, DA: w5%, DAIII: w20%) therefore different degradability microenvironments for regenerating tissue.Short long term investigations were performed...
Experimental investigation of peripheral nerve fiber regeneration is attracting more and attention among both basic clinical researchers. Assessment myelinated morphology a pillar research. The gold standard for light microscopic imaging fibers toluidine blue staining resin-embedded semithin sections. However, many researchers are unaware that the dark myelin sheaths typically produced by this procedure due to osmium tetroxide postfixation not blue. In article, we describe simple...
Electrospun fibrous substrates mimicking extracellular matrices can be prepared by electrospinning, yielding aligned as internal fillers to manufacture artificial nerves. Gelatin nano-fibers were electrospinning after tuning the collector rotation speed. The effect of alignment on cell adhesion and proliferation was tested in vitro using primary cultures, Schwann line, RT4-D6P2T, sensory neuron-like 50B11. Cell assessed quantifying at several time-points. Aligned reduced rate compared with...
Hydrogels are promising materials in regenerative medicine applications, due to their hydrophilicity, biocompatibility and capacity release drugs growth factors a controlled manner. In this study, biocompatible biodegradable hydrogels based on blends of natural polymers were used vitro ex vivo experiments as tool for VEGF-controlled accelerate the nerve regeneration process. Among different candidates, angiogenic factor VEGF was selected, since angiogenesis has been long recognized an...
Peripheral nerve lesions are frequent occurrences in both human and animal patients, leading to important physiological labor complications that affect the quality of life those who suffer injury. More severe injuries often associated with poor regeneration inadequate functional recovery, even early medical surgical interventions. crush and, therefore, an experimental lesion paradigm widely used researches involving injury models therapies for its resolution. In recent years, many studies...
Peripheral nerve lesions with a long segment defect need grafting conduit to heal. Although autogenous is still considered the best method for bridging defects, several alternative types of conduits (biological and synthetic) have been studied. We demonstrated in previous experimental research rats that graft made using vein (providing guide regeneration) filled fresh skeletal muscle (to prevent collapse support axon gave similar results traditional grafts. On this basis, we decided use...
Abstract Neuromuscular recovery after peripheral nerve lesion depends on the regeneration of severed axons that re‐establish their functional connection with denervated muscle. The aim this study was to determine effects electrical stimulation (ES) neuromuscular crush injury in rats. Electrical carried out tibialis anterior (TA) muscle sciatic a rat model. Six ES sessions were administered every other day starting from 3 postinjury until end experiment (day 14). index calculated. Muscle...
Biosynthetic guides can be an alternative to nerve grafts for reconstructing severely injured peripheral nerves. The aim of this study was evaluate the regenerative capability chitosan tubes bridge critical gaps (15 mm long) in rat sciatic compared with silicone (SIL) and autografts (AGs). A total 28 Wistar Hannover rats were randomly distributed into four groups ( n = 7 each), which repaired by SIL tube, low (∼2%, DAI) medium (∼5%, DAII) degree acetylation, AG. Electrophysiological...