A5015194708- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Pain Mechanisms and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Spinal Cord Injury Research
- Muscle activation and electromyography studies
- Cancer Treatment and Pharmacology
- Tissue Engineering and Regenerative Medicine
- Multiple Myeloma Research and Treatments
- Signaling Pathways in Disease
- Axon Guidance and Neuronal Signaling
- Hereditary Neurological Disorders
- Botulinum Toxin and Related Neurological Disorders
- Ubiquitin and proteasome pathways
- Peripheral Neuropathies and Disorders
- Conducting polymers and applications
- Proteoglycans and glycosaminoglycans research
- Neuroinflammation and Neurodegeneration Mechanisms
- Biotin and Related Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuropeptides and Animal Physiology
- Neurological Disorders and Treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
Universitat Autònoma de Barcelona
2015-2024
Instituto de Salud Carlos III
2011-2024
Centro de Investigación Biomédica en Red
2015-2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2013-2024
Women and Children’s Health Research Institute
2016
University of Alberta
2007-2016
Karolinska Institutet
2016
Mútua Terrassa
2013
Ochsner Medical Center
2009
Johns Hopkins University
2009
Biosynthetic nerve grafts are developed in order to complement or replace autologous for peripheral reconstruction. Artificial guides currently approved clinical use not widely applied reconstructive surgery as they still have limitations especially when it comes critical distance repair. Here we report a comprehensive analysis of fine-tuned chitosan (CNGs) enhanced by introduction longitudinal film reconstruct length 15 mm sciatic defects adult healthy Wistar diabetic Goto-Kakizaki rats....
The transverse intrafascicular multichannel electrode (TIME) is intended to be transversally implanted in the peripheral nerve and selectively interface subsets of axons different fascicles within same nerve. Two versions TIME (TIME-2, TIME-3) were designed tested for biocompatibility safety sciatic rat. TIME-2 was two groups: one group had only an acute implant second chronic implantation 2 months; a third also chronically with TIME-3 version, avoid mechanical traction produced by muscles...
Abstract Introduction : Lesions of peripheral nerves cause loss motor and sensory function also lead to hyperreflexia hyperalgesia. Activity‐dependent therapies promote axonal regeneration functional recovery may improve sensory–motor coordination restoration adequate circuitry at the spinal level. Methods We compared effects passive (bicycle) active (treadmill) exercise on nerve modulation H reflex after transection repair rat sciatic nerve. Animals were evaluated during 2 months using...
Knowledge of the intraneural topography peripheral nerves may help to improve nerve repair after injuries and selectivity neural interfaces. We studied fascicular pattern motor fibers rat sciatic-tibial nerve. carried out an anatomical dissection muscular tributaries tibial in leg. Immunohistochemistry against choline acetyltransferase was used identify axons. Retrograde tracing allowed localization fascicles at proximal levels sciatic trunk. The distribution transverse section is not...
Biosynthetic guides can be an alternative to nerve grafts for reconstructing severely injured peripheral nerves. The aim of this study was evaluate the regenerative capability chitosan tubes bridge critical gaps (15 mm long) in rat sciatic compared with silicone (SIL) and autografts (AGs). A total 28 Wistar Hannover rats were randomly distributed into four groups ( n = 7 each), which repaired by SIL tube, low (∼2%, DAI) medium (∼5%, DAII) degree acetylation, AG. Electrophysiological...
Recent studies explored promising new quantitative methods to analyze electroencephalography (EEG) signals. This paper analyzes the correlation of two EEG parameters, Brain Symmetry Index (BSI) and Laterality Coefficient (LC), with established functional scales for stroke assessment.Thirty-two healthy subjects thirty-six patients upper extremity hemiparesis were recruited this study. The where subdivided in three groups according location: Cortical, Subcortical, Cortical + Subcortical....
Several groups have shown that the performance of motor neuroprostheses can be significantly improved by detecting specific sensory events related to ongoing task (e.g., slippage an object during grasping). Algorithms been developed achieve this goal processing electroneurographic (ENG) afferent signals recorded using single-channel cuff electrodes. However, no efforts made so far understand number and type detectable differentiated from whole nerve recordings approach.To aim, ENG signals,...
Recruitment and repetitive firing of spinal motoneurons depend on the activation persistent inward calcium sodium currents (PICs) that are in turn facilitated by serotonin norepinephrine arise primarily from brain stem. Considering rats motoneuron PICs greatly increasing presynaptic release with amphetamine, we sought similar evidence for modulation human motoneurons. Pairs motor units were recorded during a gradually then decreasing voluntary contraction. The frequency (F) lower-threshold...
OBJECTIVE Artificial nerve guides are being developed to substitute for autograft repair after peripheral injuries. However, the use of conduits is limited by length gap that needs be bridged, with success regeneration highly compromised in long gaps. Addition aligned proregenerative cells and extracellular matrix (ECM) components inside conduit can a good strategy achieve artificial grafts recreate natural environment offered graft. The purpose this study was functionalize chitosan devices...
Fibroblast growth factor 2 (FGF‐2) is a trophic expressed by glial cells and different neuronal populations. Addition of FGF‐2 to spinal cord dorsal root ganglia (DRG) explants demonstrated that specifically increases motor neuron axonal growth. To further explore the potential capability promote axon regeneration, we produced lentiviral vector (LV) overexpress (LV‐FGF2) in injured rat peripheral nerve. Cultured Schwann transduced with added collagen matrix embedding or DRG significantly...