A5074601288- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Virus-based gene therapy research
- Botulinum Toxin and Related Neurological Disorders
- Spinal Cord Injury Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Exercise and Physiological Responses
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Biochemical effects in animals
- Muscle Physiology and Disorders
- Children's Physical and Motor Development
- Neurogenetic and Muscular Disorders Research
- Thermoregulation and physiological responses
- Vagus Nerve Stimulation Research
- Chemokine receptors and signaling
- Pain Management and Treatment
- Obesity, Physical Activity, Diet
- Musculoskeletal pain and rehabilitation
- Child Nutrition and Feeding Issues
University of Girona
2015-2025
John Wiley & Sons (United Kingdom)
2017
Universitat Autònoma de Barcelona
2011-2014
Gene Therapy Laboratory
2011
This study aimed (1) to explore the association between body composition [fat-to-muscle ratio (FMR), waist circumference (WC), and mass index (BMI)] with motor competence (MC) physical fitness (PFI) in 7-year-old children; (2) ascertain whether FMR modifies associations MC PF. A total of 164 children (7 yr) were included. Anthropometric (fat muscle calculated TANITA), (CAMSA test) (1/2 mile run, handgrip strength, 10 × 5, standing long jump, sit reach tests) variables collected. FMR, WC BMI...
Abstract Background (−)‐Epigallocatechin‐3‐gallate ( EGCG ) is the major polyphenolic constituent found in green tea. It has been reported that may be a natural agent for reducing thermal and mechanical pain after nervous system injuries. However, molecular pathways implicated these beneficial effects have not completely elucidated. This study aimed to assess treatment on hyperalgesia, spinal cord gliosis modulation of Ras homologue gene family member A (RhoA), fatty acid synthase FASN...
Abstract Nociplastic pain arises from altered nociception despite no clear evidence of tissue or somatosensory system damage, and fibromyalgia syndrome can be highlighted as a prototype this chronic subtype. Currently, there is lack effective treatments to alleviate both reflexive nonreflexive responses associated with condition, suitable preclinical models are needed assess new pharmacological strategies. In context, although in recent years some remarkable animal have been developed mimic...
Abstract Introduction Nociplastic pain involves reflexive and nonreflexive responses it is a core symptom of fibromyalgia (FM). The increasing prevalence this health condition the low rates patients’ quality life, combined with lack suitable pharmacologic treatments, evidence demand to research new alternatives. Polyphenols may be potential therapeutic candidates as they have been reported exert pathological modulation in preclinical models. In that context, work was aimed study...
Different adeno-associated virus (AAV) serotypes efficiently transduce neurons from central and peripheral nervous systems through various administration routes. Direct of the vectors to cerebrospinal fluid (CSF) could be an efficient safe strategy. Here, we show that lumbar puncture a nonhuman AAV leads wide stable distribution vector along spinal cord in adult mice. AAVrh10 specifically infects neurons, both dorsal root ganglia (60% total sensory neurons) (up one-third α-motor neurons). As...
The non‐obese diabetic (NOD) mouse was suggested as an adequate model for autonomic neuropathy. We evaluated sensory‐motor neuropathy and nerve regeneration following sciatic crush in NOD males rendered by multiple low doses of streptozotocin, comparison with similarly treated Institute Cancer Research (ICR) mice, a widely used type I diabetes. Neurophysiological values both strains showed decline motor sensory conduction velocity at 7 8 weeks after induction diabetes the intact hindlimb....
(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the neuropathic pain alleviation animal models. Because chemokine fractalkine (CX3CL1) has been suggested as an important signal during development, this study aimed to investigate whether CX3CL1 expression may be modulated by EGCG treatment reducing hyperalgesia chronic constriction injured mice. To end, Balb/c mice were subjected injury of sciatic nerve (CCI) and treated or vehicle once day...