A5053805076- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Spinal Cord Injury Research
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience and Neural Engineering
- Cardiac Arrhythmias and Treatments
- Pain Management and Placebo Effect
- Cardiac pacing and defibrillation studies
- Veterinary Pharmacology and Anesthesia
- Neuroscience and Neuropharmacology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Chemokine receptors and signaling
- Biochemical effects in animals
- Botulinum Toxin and Related Neurological Disorders
- Acupuncture Treatment Research Studies
- Musculoskeletal pain and rehabilitation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cardiac electrophysiology and arrhythmias
- Neurological disorders and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
Universitat Pompeu Fabra
2021-2022
University of Girona
2016-2022
John Wiley & Sons (United Kingdom)
2017
University of Puerto Rico, Medical Sciences Campus
1972
Abstract Nociplastic pain arises from altered nociception despite no clear evidence of tissue or somatosensory system damage, and fibromyalgia syndrome can be highlighted as a prototype this chronic subtype. Currently, there is lack effective treatments to alleviate both reflexive nonreflexive responses associated with condition, suitable preclinical models are needed assess new pharmacological strategies. In context, although in recent years some remarkable animal have been developed mimic...
(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the neuropathic pain alleviation animal models. Because chemokine fractalkine (CX3CL1) has been suggested as an important signal during development, this study aimed to investigate whether CX3CL1 expression may be modulated by EGCG treatment reducing hyperalgesia chronic constriction injured mice. To end, Balb/c mice were subjected injury of sciatic nerve (CCI) and treated or vehicle once day...
Sigma-1 receptor (σ1R) ligands have been shown to be effective at relieving neuropathic and inflammatory pain, but not yet tested in experimental models of fibromyalgia. The objective this study was evaluate the effect a σ1R antagonist (BD1063) compared pregabalin. ICR-CD1 female mice were subjected either six repeated injections reserpine, cause reserpine-induced myalgia (RIM6), or acidified saline intramuscular (ASI). In these two models, we evaluated BD1063 pregabalin on thermal...
The influence of temperature, contractures, and CA²⁺ on the processes healing over muscle contraction was investigated in toad myocardium by simultaneously measuring size injury potential twitch tension. Stimulation with single pulses electrically induced contractures short duration (2-3 seconds) markedly increased rate healing, epinephrine (10⁻⁶ g/ml) effectiveness stimulation. Other results supported view that process largely dependent since at 15°C or 10°C greatly reduced. effect...
The search for safe and efficient chronic pain treatments is dampened by the lack of reliable models that faithfully reproduce current pharmacological spontaneous in humans. Preclinical often assess antinociceptive efficacy non-contingent evaluated short-term. Here, we provide a protocol contingent operant self-medication mice, which allows estimation relief drug abuse liability persistent pain. This paradigm requires preliminary habituation animal handling, followed training mice...