A5065917417- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Children's Physical and Motor Development
- Cardiovascular Disease and Adiposity
- Genetic Syndromes and Imprinting
- Cardiovascular Health and Disease Prevention
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Growth Hormone and Insulin-like Growth Factors
- Iron Metabolism and Disorders
- Vitamin D Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pancreatic function and diabetes
- Prenatal Screening and Diagnostics
- Sports Performance and Training
- Sports injuries and prevention
- Blood Pressure and Hypertension Studies
- Hemoglobinopathies and Related Disorders
- Metabolism, Diabetes, and Cancer
- Physical Activity and Health
University of Girona
2016-2025
Institut d'Investigació Biomèdica de Girona
2012-2023
NEOMA Business School
2023
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2020
Health Sciences Centre
2020
Hospital Universitari de Girona Doctor Josep Trueta
2010-2019
Departament de Salut
2018
Instituto de Salud Carlos III
2015
Pediatrics and Genetics
2014
Abstract Context: Circulating microRNAs (miRNAs) are valuable biomarkers of metabolic diseases and potential therapeutic targets in this field. Objective: Our objective was to define the circulating pattern miRNAs childhood obesity. Design, Settings, Main Outcome Measure: The genome-wide miRNA profile assessed by RT-PCR 10 boys (5 lean 5 obese children). most relevant were cross-sectionally validated 85 versus 40 children (63 62 girls) longitudinally evaluated samples from same when they ∼7...
MicroRNAs (miRNAs) are valuable circulating biomarkers and therapeutic targets for metabolic diseases.The objective of the study was to define pattern miRNAs in pregestational gestational obesity explore their associations with maternal parameters markers pre- postnatal growth. design, settings, main outcome measure: TaqMan low-density arrays were used profile plasma six women (PregestOB), (GestOB), normal pregnancies (control) during second trimester gestation. The most relevant validated...
Context: A lower free T4 (fT4), within the euthyroid range, has been shown in adults to associate with an adverse metabolic phenotype. Thyroid physiology changes significantly during gestation and affects maternal fetal well-being. Objective: The aim of study was test hypothesis that a serum fT4 healthy pregnant women is related less favorable phenotype or placental weight. Design, Setting, Patients, Outcome Measures: We examined associations thyroid function tests (TSH fT4) T3 (fT3)-to-fT4...
It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy CVD risk, in children and adolescents.Data were available for 3,497 adolescents aged 6-17 years from five population-based cross-sectional studies Brazil, China, Greece, Italy, Spain. Weight status categories (normal, overweight, obese) defined using BMI cutoffs International Obesity...
Context:Human placenta exhibits a specific microRNA (miRNA) expression pattern. Some of these miRNAs are dysregulated in pregnancy disorders such as preeclampsia and intrauterine growth restriction potential biomarkers for pathologies.
Physical exercise has been shown to induce epigenetic modifications with various health implications, directly affect DNA methylation (DNAm), as well reverse the age. Hence, we aimed identify differential changes and assess age in saliva of 7-9-year-old school children following a 3-month integrated neuromuscular training (INT), explore if any are core genes. Core genes defined high relevance essential importance within human genome. Forty (17 boys 23 girls) were recruited from schools...
Abstract Background The impact of Prader–Willi syndrome (PWS) domain gene expression on the growth healthy children is not well understood. This study investigated associations between PWS in umbilical cord tissue and prenatal postnatal growth, considering potential sex differences. Methods Relative paternally expressed MAGEL2 , NDN SNURF-SNRPN small nucleolar RNAs SNORD116 SNORD115 were determined by real-time quantitative polymerase chain reaction from 122 newborns (59 girls 63 boys). Gene...
In sports science, accurate tracking of athletes’ movement patterns is essential for performance analysis and injury prevention. Changes direction (COD), frequently executed during basketball games at cutting angles around 135° (internal angle 45°), are agility high-level performance. Moreover, mastering effective COD mechanics associated with a lower risk injuries enhanced long-term athletic success. However, manual segmentation data from wearable sensors labor-intensive time-consuming,...
This study aimed (1) to explore the association between body composition [fat-to-muscle ratio (FMR), waist circumference (WC), and mass index (BMI)] with motor competence (MC) physical fitness (PFI) in 7-year-old children; (2) ascertain whether FMR modifies associations MC PF. A total of 164 children (7 yr) were included. Anthropometric (fat muscle calculated TANITA), (CAMSA test) (1/2 mile run, handgrip strength, 10 × 5, standing long jump, sit reach tests) variables collected. FMR, WC BMI...
OBJECTIVE Osteocalcin (OC), a bone-derived protein, was recently shown to regulate metabolic pathways in mice. Undercarboxylated OC (ucOC), but not carboxylated (cOC), increases adiponectin and insulin secretion. It is unclear if carboxylation of affects its association with parameters humans. RESEARCH DESIGN AND METHODS The associations between ucOC, cOC, total high-molecular-weight (HMW) adiponectin, secretion (homeostasis model assessment [HOMA]-β) were investigated population-based...
Background Metformin treatment (1000–2000 mg/day) over 6 months in pubertal children and/or adolescents with obesity and hyperinsulinism is associated a reduction body mass index (BMI) the insulin resistance (HOMA-IR). We aimed to ascertain if long-term (24 months) lower doses of metformin (850 normalizes endocrine-metabolic abnormalities, improves composition, reduces carotid intima-media thickness (cIMT) pre-puberal early obesity. Methods A pilot double-blind, placebo-controlled trial was...
Omentin-1 is a recently recognized adipokine primarily originating in visceral adipose tissue. We posited that circulating omentin-1 could be an early marker of metabolic dysfunction. To this end, we examined the associations between omentin-1, body fat (bioelectric impedance), endocrine-metabolic profile (homeostasis model assessment for insulin resistance (HOMA(IR)), serum lipids, high-molecular-weight (HMW) adiponectin and blood pressure (BP)) family history obesity diabetes asymptomatic...
The clinical utility of screening for pediatric metabolic syndrome (MetS) in children and adolescents is still controversial. We examined the performance MetS vs. clustering cardiovascular risk factors (which are components MetS) predicting high carotid intima-media thickness (cIMT) adolescents.Participants included 2427 aged 6-17 years from population-based studies three countries (Brazil, China Italy). Pediatric was defined using either modified National Cholesterol Education Program Adult...
Catch-up growth in infants who are small for gestational age (SGA) is a risk factor the development of cardiometabolic diseases adulthood. The basis and mechanisms underpinning catch-up newborns SGA unknown.To identify umbilical cord miRNAs associated with study their relationship offspring's parameters.miRNA PCR panels were used to miRNA profile tissue five (SGA-CU), without (SGA-nonCU), control [appropriate (AGA)]. smallest nominal P values validated 64 (22 AGA, 18 SGA-nonCU, 24 SGA-CU)...
Background High-molecular-weight adiponectin (HMW-adiponectin) is a cardio-metabolic health protector. Objectives: (1) to compare body mass index (BMI), cardiorespiratory fitness (CRF) and muscle strength (MS) in healthy school-children depending on their baseline salivary-HMW-adiponectin concentration; (2) apply 3-month integrated neuromuscular training (INT) evaluate its effects concentration, BMI, CRF MS the same children. Additional goal: identify if any potential changes during period...
Increased uric acid is an independent biomarker for cardiovascular disease in obese adolescents and adults.We investigated whether relates to carotid intima-media thickness (cIMT) prepubertal children, body mass index (BMI) preperitoneal fat modulate this association.359 asymptomatic Caucasian children were stratified according BMI categories (171 with BMI-SDS < 0; 188 ≥ 0) levels (180 <50th centile; 179 >50th centile). Uric levels, insulin resistance (homeostasis model assessment...
Summary Low-grade chronic inflammation plays a pathogenic role in cardiovascular disease. An increase the ratio of circulating neutrophils to lymphocytes (N/L ratio) may serve as marker risk adults. It was study objective whether N/L associates with vascular parameters children. Subjects were 501 prepubertal and early pubertal Caucasian children (mean age 8.0 years; mean body mass index (BMI) Z-score 0.2 ± 0.9; 266 boys 235 girls) recruited within an ongoing population-based study. The...