A5035520316- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Genetic Syndromes and Imprinting
- MicroRNA in disease regulation
- Growth Hormone and Insulin-like Growth Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Thyroid Disorders and Treatments
- Obesity, Physical Activity, Diet
- Cardiovascular Disease and Adiposity
- Folate and B Vitamins Research
- Ovarian function and disorders
- Metabolism, Diabetes, and Cancer
- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
- Iron Metabolism and Disorders
- Prenatal Screening and Diagnostics
- Diabetes Treatment and Management
- Hemoglobinopathies and Related Disorders
- Diabetes Management and Research
- Sexual Differentiation and Disorders
Institut d'Investigació Biomèdica de Girona
2016-2025
University of Girona
2011-2024
Hospital Universitari de Girona Doctor Josep Trueta
2014-2023
University of Tartu
2018-2022
Hospital de Sant Pau
1996-2021
Universitat Autònoma de Barcelona
1998-2020
Instituto de Salud Carlos III
2015
Clínica Girona
2015
Pediatrics and Genetics
2014
Hospital San Juan de la Cruz
2013
MicroRNAs (miRNAs) are valuable circulating biomarkers and therapeutic targets for metabolic diseases.The objective of the study was to define pattern miRNAs in pregestational gestational obesity explore their associations with maternal parameters markers pre- postnatal growth. design, settings, main outcome measure: TaqMan low-density arrays were used profile plasma six women (PregestOB), (GestOB), normal pregnancies (control) during second trimester gestation. The most relevant validated...
It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy CVD risk, in children and adolescents.Data were available for 3,497 adolescents aged 6-17 years from five population-based cross-sectional studies Brazil, China, Greece, Italy, Spain. Weight status categories (normal, overweight, obese) defined using BMI cutoffs International Obesity...
Context:Human placenta exhibits a specific microRNA (miRNA) expression pattern. Some of these miRNAs are dysregulated in pregnancy disorders such as preeclampsia and intrauterine growth restriction potential biomarkers for pathologies.
Introduction Klotho is an anti-aging protein that reduces adiposity and increases caloric expenditure, among others. Although associations between secreted α-Klotho levels obesity have been described, its relationship with central visceral fat accumulation during childhood poorly understood. Our objective was to study the longitudinal serum concentrations obesity-related parameters in apparently healthy children. Subjects methods We studied a cohort of 208 school-age children (107 girls 101...
Abstract Background The impact of Prader–Willi syndrome (PWS) domain gene expression on the growth healthy children is not well understood. This study investigated associations between PWS in umbilical cord tissue and prenatal postnatal growth, considering potential sex differences. Methods Relative paternally expressed MAGEL2 , NDN SNURF-SNRPN small nucleolar RNAs SNORD116 SNORD115 were determined by real-time quantitative polymerase chain reaction from 122 newborns (59 girls 63 boys). Gene...
Background Metformin treatment (1000–2000 mg/day) over 6 months in pubertal children and/or adolescents with obesity and hyperinsulinism is associated a reduction body mass index (BMI) the insulin resistance (HOMA-IR). We aimed to ascertain if long-term (24 months) lower doses of metformin (850 normalizes endocrine-metabolic abnormalities, improves composition, reduces carotid intima-media thickness (cIMT) pre-puberal early obesity. Methods A pilot double-blind, placebo-controlled trial was...
miR-10a-5p has been shown to regulate cancer cell proliferation and invasiveness endothelial inflammatory responses. The function of in the skin not previously studied. aim current study was examine expression, regulation, keratinocytes (KCs) association with atopic dermatitis (AD).The expression its target genes analyzed using RT-qPCR, mRNA array analysis, situ hybridization, immunofluorescence. transfection miRNA mimics, cycle distribution luciferase assays used functions human primary...
An epigenomic approach was used to study the impact of maternal pregestational body mass index (BMI) on placenta and umbilical cord methylomes their potential effect offspring's metabolic phenotype. DNA methylome assessed in 24 paired samples. The differentially methylated CpGs associated with BMI were identified pathways potentially related diseases affected by annotated genes determined. Two top studied 90 additional samples relationship phenotype results showed that is methylation...
The clinical utility of screening for pediatric metabolic syndrome (MetS) in children and adolescents is still controversial. We examined the performance MetS vs. clustering cardiovascular risk factors (which are components MetS) predicting high carotid intima-media thickness (cIMT) adolescents.Participants included 2427 aged 6-17 years from population-based studies three countries (Brazil, China Italy). Pediatric was defined using either modified National Cholesterol Education Program Adult...
Catch-up growth in infants who are small for gestational age (SGA) is a risk factor the development of cardiometabolic diseases adulthood. The basis and mechanisms underpinning catch-up newborns SGA unknown.To identify umbilical cord miRNAs associated with study their relationship offspring's parameters.miRNA PCR panels were used to miRNA profile tissue five (SGA-CU), without (SGA-nonCU), control [appropriate (AGA)]. smallest nominal P values validated 64 (22 AGA, 18 SGA-nonCU, 24 SGA-CU)...
Abstract Atopic dermatitis (AD) and psoriasis vulgaris (PV) are chronic inflammatory skin diseases with heterogeneous molecular backgrounds. MicroRNAs (miRNAs) contribute to either development or regulation of many immune system related diseases. Only few miRNA profiling studies available for AD no comparisons between PV profiles have been performed recently. We conducted a analysis skin, as well serum, from adult patients control individuals. 130 miRNAs were differentially expressed in...
Increased uric acid is an independent biomarker for cardiovascular disease in obese adolescents and adults.We investigated whether relates to carotid intima-media thickness (cIMT) prepubertal children, body mass index (BMI) preperitoneal fat modulate this association.359 asymptomatic Caucasian children were stratified according BMI categories (171 with BMI-SDS < 0; 188 ≥ 0) levels (180 <50th centile; 179 >50th centile). Uric levels, insulin resistance (homeostasis model assessment...
Summary Low-grade chronic inflammation plays a pathogenic role in cardiovascular disease. An increase the ratio of circulating neutrophils to lymphocytes (N/L ratio) may serve as marker risk adults. It was study objective whether N/L associates with vascular parameters children. Subjects were 501 prepubertal and early pubertal Caucasian children (mean age 8.0 years; mean body mass index (BMI) Z-score 0.2 ± 0.9; 266 boys 235 girls) recruited within an ongoing population-based study. The...
Background High-molecular-weight adiponectin (HMW-adiponectin) is a cardio-metabolic health protector. Objectives: (1) to compare body mass index (BMI), cardiorespiratory fitness (CRF) and muscle strength (MS) in healthy school-children depending on their baseline salivary-HMW-adiponectin concentration; (2) apply 3-month integrated neuromuscular training (INT) evaluate its effects concentration, BMI, CRF MS the same children. Additional goal: identify if any potential changes during period...