A5041639303- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Growth Hormone and Insulin-like Growth Factors
- Genetic Syndromes and Imprinting
- Cardiovascular Health and Disease Prevention
- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Parathyroid Disorders and Treatments
- Neonatal Health and Biochemistry
- Metabolism, Diabetes, and Cancer
- Prenatal Screening and Diagnostics
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Regulation of Appetite and Obesity
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Obesity, Physical Activity, Diet
- Cardiovascular Disease and Adiposity
- Infant Nutrition and Health
- Heme Oxygenase-1 and Carbon Monoxide
Institut d'Investigació Biomèdica de Girona
2018-2025
It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy CVD risk, in children and adolescents.Data were available for 3,497 adolescents aged 6-17 years from five population-based cross-sectional studies Brazil, China, Greece, Italy, Spain. Weight status categories (normal, overweight, obese) defined using BMI cutoffs International Obesity...
Abstract Background The impact of Prader–Willi syndrome (PWS) domain gene expression on the growth healthy children is not well understood. This study investigated associations between PWS in umbilical cord tissue and prenatal postnatal growth, considering potential sex differences. Methods Relative paternally expressed MAGEL2 , NDN SNURF-SNRPN small nucleolar RNAs SNORD116 SNORD115 were determined by real-time quantitative polymerase chain reaction from 122 newborns (59 girls 63 boys). Gene...
Accumulating evidence suggests that the predisposition to metabolic diseases is established in utero through epigenomic modifications. However, it remains unclear whether childhood obesity results from preexisting alterations or itself induces changes epigenome. This study aimed identify DNA methylation marks placenta associated with obesity-related outcomes children at age 6 and assess these blood samples they correlate time. Using an epigenome-wide microarray on 24 placental samples, we...
Introduction Klotho is an anti-aging protein that reduces adiposity and increases caloric expenditure, among others. Although associations between secreted α-Klotho levels obesity have been described, its relationship with central visceral fat accumulation during childhood poorly understood. Our objective was to study the longitudinal serum concentrations obesity-related parameters in apparently healthy children. Subjects methods We studied a cohort of 208 school-age children (107 girls 101...
Background Metformin treatment (1000–2000 mg/day) over 6 months in pubertal children and/or adolescents with obesity and hyperinsulinism is associated a reduction body mass index (BMI) the insulin resistance (HOMA-IR). We aimed to ascertain if long-term (24 months) lower doses of metformin (850 normalizes endocrine-metabolic abnormalities, improves composition, reduces carotid intima-media thickness (cIMT) pre-puberal early obesity. Methods A pilot double-blind, placebo-controlled trial was...
An epigenomic approach was used to study the impact of maternal pregestational body mass index (BMI) on placenta and umbilical cord methylomes their potential effect offspring's metabolic phenotype. DNA methylome assessed in 24 paired samples. The differentially methylated CpGs associated with BMI were identified pathways potentially related diseases affected by annotated genes determined. Two top studied 90 additional samples relationship phenotype results showed that is methylation...
Catch-up growth in infants who are small for gestational age (SGA) is a risk factor the development of cardiometabolic diseases adulthood. The basis and mechanisms underpinning catch-up newborns SGA unknown.To identify umbilical cord miRNAs associated with study their relationship offspring's parameters.miRNA PCR panels were used to miRNA profile tissue five (SGA-CU), without (SGA-nonCU), control [appropriate (AGA)]. smallest nominal P values validated 64 (22 AGA, 18 SGA-nonCU, 24 SGA-CU)...
The goals were to investigate in umbilical cord tissue if gestational obesity: (1) was associated with changes DNA methylation of skeletal muscle-specific genes; (2) could modulate the co-methylation interactions among these genes. Additionally, we assessed associations between levels and infant's variables at birth age 6. measured sixteen pregnant women [8-gestational obesity group; 8-control group] using Infinium Methylation EPIC Bead Chip microarray. Differentially methylated CpGs...
Introduction: Fatty acids are essential nutrients for the fetus and supplied by mother through placenta.Desaturase elongase enzymes play an important role in modulating fatty acid composition of body tissues.We aimed to compare profile estimated desaturase activities placenta appropriate (AGA) versus small-for-gestational-age (SGA), determine their relationship with offspring size at birth.Methods: The placental was analyzed gas chromatography 84 infants (45 AGA 30 SGA) from a prenatal...
Abstract Objective Offspring exposed to gestational obesity have an increased risk for chronic diseases. Increasing evidence suggests that epigenetics may play a mechanistic role in metabolic programming. This study aimed identify placental DNA methylation marks associated with weight gain (GWG) and their association offspring parameters at school age. Methods A global array was performed 24 placentas from mothers different degrees of GWG (screening sample). The percentage four...
Excessive gestational weight gain (GWG) has a negative impact on offspring's health. Epigenetic modifications mediate these associations by causing changes in gene expression. We studied the association between GWG and DNA methylation umbilical cord tissue; determined whether expression of corresponding annotated genes were associated with obesity-related parameters offspring at 6 years age. The methylated CpG sites (CpGs) identified tissue genome-wide (n = 24). Twelve top CpGs validated...
Limited nutrient supply to the fetus results in physiologic and metabolic adaptations that have unfavorable consequences offspring. In a swine animal model, we aimed study effects of gestational caloric restriction early postnatal metformin administration on offspring’s adipose tissue epigenetics their association with morphometric variables. Sows were either underfed (30% total food) or kept under standard diet during gestation, piglets randomly assigned at birth receive (n = 16 per group)...
Summary Background Metformin treatment for 24 months in children with obesity lowers body mass index (BMI), reduces liver fat, and normalizes endocrine‐metabolic parameters. Objective Here we study whether circulating GDF‐15 levels were raised by such metformin they related to changes weight visceral fat obesity. Methods The population consisted of 18 pre‐pubertal/early pubertal who had participated a randomized double‐blind clinical trial receiving (850 mg/day) or placebo months....
Thyroid hormones play major roles in the regulation of body composition and metabolism, therefore, relationship between thyroid cardio-metabolic risk has been extensively studied adults. In this study, we aimed to test whether free triiodothyronine (fT3) associates longitudinally with factors euthyroid children. A prospective study cohort 599 apparently healthy school-age children were assessed at baseline (mean age 8.1 ± 2.1 years), whom 270 also follow-up (4 years later). Circulating...
Abstract Associations between glomerular filtration rate (GFR) and cardiometabolic risk factors have been reported in adult pediatric patients with renal disease. We aimed to assess the relationship estimated GFR (eGFR) apparently healthy children. A longitudinal study 401 asymptomatic Caucasian children (mean age 8 years) followed up after 4 years 12 years). was using form of FAS-equation. Children were classified at baseline according their obesity status (normal weight overweight) eGFR...
Abstract Renal size is an important parameter for the evaluation and diagnosis of kidney disease has been associated with several cardiovascular risk factors in patients failure. These results are however discordant studies healthy children lacking. We aimed to study association between renal (length volume) parameters children. Clinical, analytical ultrasound [renal length, volume, perirenal fat carotid intima-media thickness (cIMT)] were determined 515 prepubertal (176 lean, 208 overweight...
Objective Bilirubin and triglycerides can regulate insulin secretion glucose uptake. The aim of our study is to analyze associations between total bilirubin (TB) the bilirubin-to-triglycerides ratio (BTR) with metabolic markers in healthy prepubertal children. Methods Subjects were 246 children (mean age 8), whom 142 (58%) reevaluated 4 years later 12). subjects stratified according into three groups (<7.8 years; 7.8-9.6 >9.6 n=82 each) at baseline two (<12.9 ≥12.9 n=71...
Abstract Objective To study the association between insulin-like growth factor 1 (IGF-1) and blood pressure in children, particular, potential interaction with serum calcium-phosphorus product (Ca*P). Methods A longitudinal included 521 children (age 8.8 ± 0.1) from northeastern Spain, of whom 158 were followed-up after 5 years. IGF-1, factor-binding protein 3 (IGFBP-3), calcium phosphorus measured at baseline. Anthropometric (body-mass index [BMI] waist) cardiometabolic variables (systolic...
During pregnancy, maternal polyunsaturated fatty acids (PUFA) are transferred to the fetus through placenta by specific FA transporters (FATP). A higher perinatal exposure n-6 over n-3 PUFA could be linked excess fat mass and obesity development later in life. In this context, we aimed assess associations between long chain PUFAs (LC-PUFAs) (n-6, n-3, n-6/n-3 ratios) measured at term birth with obesity-related parameters offspring 6 years of age whether these dependent on placental relative...
Abstract Both the innate and adaptive immune responses are deregulated in individuals with obesity key drivers of its associated metabolic alterations. Although anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, mechanisms regulating not fully cleared. We examined whether GDF-15 was related to serum immunoglobulins children’s cohort assessed longitudinally during childhood. Results showed that circulating positively IgA (p < 0.002) IgG...