A5017202714- Proteoglycans and glycosaminoglycans research
- NF-κB Signaling Pathways
- Schizophrenia research and treatment
- Osteoarthritis Treatment and Mechanisms
- Bipolar Disorder and Treatment
- Pharmacological Effects and Toxicity Studies
- Fibroblast Growth Factor Research
- Immune Response and Inflammation
- Epilepsy research and treatment
- Electroconvulsive Therapy Studies
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Natural product bioactivities and synthesis
- Pharmacological Receptor Mechanisms and Effects
- Pharmacogenetics and Drug Metabolism
- Protease and Inhibitor Mechanisms
- Cardiac Ischemia and Reperfusion
- Electron Spin Resonance Studies
- Platelet Disorders and Treatments
- Treatment of Major Depression
- Glycosylation and Glycoproteins Research
- Ocular Surface and Contact Lens
- Seaweed-derived Bioactive Compounds
- Tryptophan and brain disorders
University of Messina
2015-2024
Institute of Pharmacology
1993-2001
University of Pavia
1994-1998
To evaluate the antioxidant activity of glycosaminoglycans hyaluronic acid (HYA) and chondroitin-4-sulphate (C4S), we used a rat model collagen-induced arthritis (CIA). Arthritis was induced in Lewis rats by multiple intradermal injections 250 μl emulsion containing bovine type II collagen complete Freund's adjuvant at base tail into three to five other sites on back. Rats were challenged again with same antigen preparation 7 days later. Disease developed about 11 after second immunization....
The effect of the selective serotonin reuptake inhibitor fluvoxamine (100 mg/day for 10 consecutive days) on kinetics a single oral dose imipramine (50 mg) and desipramine was investigated in 12 healthy subjects. Compared with control session, treatment caused significant prolongation half-life (from 22.8 +/- 6.4 to 40.5 5.0 h, means SD, p < 0.01) marked decrease apparent clearance 1.02 0.19 0.28 0.06 L/h/kg, 0.0001). No changes were observed during treatment. These findings indicate that,...
The effect of fluoxetine on the steady-state plasma concentrations risperidone and its active metabolite 9-hydroxyrisperidone (9-OH-risperidone) was evaluated in 10 patients with schizophrenia or schizoaffective disorder. Patients stabilized (4–6 mg/day) received additional (20 to treat concomitant depression. One patient dropped out after 1 week due occurrence akathisia associated markedly increased concentrations. In other subjects, mean during administration from 12 ± 9 ng/mL at baseline...
Abstract Previous studies reported that hyaluronic acid (HA), chondroitin sulphate (CS) and heparan (HS) were able to reduce the inflammatory process in a variety of cell types after lypopolysaccharide (LPS) stimulation. The aim this study was investigate anti‐inflammatory effect glycosaminoglycans (GAGs) mouse articular chondrocytes stimulated with LPS. Chondrocyte treatment LPS (50 µg/ml) generated high levels TNF‐α, IL‐1β, IL‐6, IFN‐γ, MMP‐1, MMP‐13, iNOS gene expression their related...
Broad antiinflammatory effects following adenosine A(₂A) receptor stimulation have been demonstrated in acute inflammatory diseases, including arthritis. Polydeoxyribonucleotide (PDRN) activates the receptor. This study was undertaken to investigate of PDRN collagen-induced arthritis (CIA) mice.Arthritis induced DBA/1 mice by an intradermal injection 100 μl bovine type II collagen Freund's complete adjuvant. Mice were immunized a second time 21 days later. Control animals received saline...
Abstract Hyaluronic acid (HA) may exert different action depending on its degree of polymerization. Small HA fragments induce proinflammatory responses, while highly polymerized exerts a protective effect in inflammatory pathologies such as rheumatoid arthritis. In both cases the toll‐like receptor 4 (TLR‐4) seems to be involved modulation inflammation process. The aim this study was investigate influence short oligosaccharides (HA 4‐mers) and high molecular weight (HMWHA) response normal...
β-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that tempers inflammation. An interaction between the CB2 and peroxisome proliferator-activated gamma (PPAR-γ) has been suggested PPAR-γ activation exerts anti-arthritic effects. The aim of this study was to characterize therapeutic activity BCP investigate involvement in collagen antibody induced arthritis (CAIA) experimental model. CAIA through intraperitoneal injection monoclonal cocktail lipopolysaccharide (LPS; 50 μg/100...
To evaluate the pharmacokinetic interaction between risperidone and mood-stabilizing agents carbamazepine valproic acid, steady state plasma concentrations of 9-hydroxyrisperidone (9-OH-risperidone) were compared in patients treated with alone (controls, n = 23) comedicated (n 11) or sodium valproate 10). The three groups matched for sex, age, body weight, antipsychotic dosage. Plasma 9-OH-risperidone did not differ valproate-comedicated controls. By contrast, both compounds lower taking...
The effects of paroxetine on steady-state plasma concentrations risperidone and its active metabolite 9-hydroxyrisperidone (9-OH-risperidone) were studied in 10 patients with schizophrenia or schizoaffective disorder. Patients stabilized using therapy (4–8 mg/d) also received (20 for 4 weeks. During administration, mean increased significantly (P < 0.01), whereas levels 9-OH-risperidone decreased slightly but not significantly. After weeks treatment, the sum (active moiety) by 45% 0.05) over...
Abstract Hyaluronan (HA) degradation produces small oligosaccharides that are able to increase pro‐inflammatory cytokines in rheumatoid arthritis synovial fibroblasts (RASF) by activating both CD44 and the toll‐like receptor 4 (TLR‐4). TLR‐4 stimulation turn activate NF‐kB induces production of cytokines. Degradation HA occurs via two mechanisms: one exerted reactive oxygen species (ROS) controlled different enzymes particular hyaluronidases (HYALs). We aimed investigate effects inhibiting...
Two separate studies were carried out to assess the effect of valproic acid on steady-state plasma concentrations clozapine and its major metabolites norclozapine N-oxide in psychotic patients. In first study, compared between patients treated with combination sodium valproate (n = 15) control alone 22) matched for sex, age, body weight, antipsychotic dosage. Patients comedicated tended have higher levels lower levels, but differences did not reach statistical significance. a subsequent...
We describe four patients in whom the addition of fluvoxamine (100 mg/day) to treatment with imipramine or desipramine (100–150 resulted a dramatic increase plasma concentrations tricyclic antidepressants associated adverse effects. These observations indicate that inhibits both demethylation and, possibly lesser extent, hydroxylation desipramine. The combination should be avoided whenever possible.
Carbon tetrachloride (CCl4)-induced hepatotoxicity is likely the result of a CCl4-induced free radical production which causes membrane lipid peroxidation and activation transcription factors regulating both TNF-α gene early-immediate genes involved in tissue regeneration. IRFI 042 novel vitamin E-like compound having masked sulphydryl group aliphatic side chain. We studied effect on liver injury. Liver damage was induced male rats by an intraperitoneal injection CCl4 (1 ml/kg vegetal oil)....