A5083690016- Proteoglycans and glycosaminoglycans research
- NF-κB Signaling Pathways
- Lipoproteins and Cardiovascular Health
- Inflammation biomarkers and pathways
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Immune Response and Inflammation
- Adenosine and Purinergic Signaling
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Platelet Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Pancreatitis Pathology and Treatment
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Neuropeptides and Animal Physiology
- Fibroblast Growth Factor Research
- Receptor Mechanisms and Signaling
- Coronary Interventions and Diagnostics
- Biomarkers in Disease Mechanisms
- Methodologies in Health Research and Practice
- Diabetes, Cardiovascular Risks, and Lipoproteins
University of Messina
2015-2024
BAY 11-7082 antagonizes I-κB kinase-β preventing nuclear translocation of factor-κB (NF-κB); it also inhibits NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation. NF-κB is involved in psoriasis, whereas the role NLRP3 controversial. We investigated effects an experimental model psoriasis-like dermatitis. Psoriasis-like lesions were induced by a topical application imiquimod (IMQ) cream (62.5 mg/day) on shaved back skin C57BL/6 and knockout (KO) mice for 7...
Abstract Hyaluronic acid (HA) may exert different action depending on its degree of polymerization. Small HA fragments induce proinflammatory responses, while highly polymerized exerts a protective effect in inflammatory pathologies such as rheumatoid arthritis. In both cases the toll‐like receptor 4 (TLR‐4) seems to be involved modulation inflammation process. The aim this study was investigate influence short oligosaccharides (HA 4‐mers) and high molecular weight (HMWHA) response normal...
Abstract Hyaluronan (HA) degradation produces small oligosaccharides that are able to increase pro‐inflammatory cytokines in rheumatoid arthritis synovial fibroblasts (RASF) by activating both CD44 and the toll‐like receptor 4 (TLR‐4). TLR‐4 stimulation turn activate NF‐kB induces production of cytokines. Degradation HA occurs via two mechanisms: one exerted reactive oxygen species (ROS) controlled different enzymes particular hyaluronidases (HYALs). We aimed investigate effects inhibiting...
Small hyaluronan (HA) fragments produced from native HA during inflammation contribute greatly to cell injury in many pathologies. oligosaccharides increase proinflammatory cytokine levels by activating both CD44 and toll‐like receptor (TLR)‐4. Stimulation of TLR‐4 then activates nuclear factor‐κB, which induces the production cytokines. The adenosine 2A (A R) is also involved several pathologies, nucleoside acts as a potent endogenous inhibitor various tissues interacting with this...
Cardiac fibrosis is a common pathological feature of different cardiovascular diseases, characterized by the aberrant deposition extracellular matrix (ECM) proteins in cardiac interstitium, myofibroblast differentiation and increased fibrillar collagen stimulated transforming growth factor (TGF)-β activation. Biglycan (BGN), small leucine-rich proteoglycan (SLRPG) integrated within ECM, plays key role assembly phenotypic control fibroblasts. Moreover, BGN critically involved remodeling...
4-mer hyaluronan (HA) oligosaccharides stimulate pro-inflammatory effects in different cell types by interacting with both the toll-like receptor-4 (TLR-4) and -2 (TLR-2). This interaction induces activation of transforming growth factor activated kinase-1 (TAK-1) that activates nuclear kappaB (NF-kB) either directly and/or through p38-mitogen-activated protein kinase (p38-MAPK). turn transcription proinflammatory mediators prime inflammation. Our aim was to investigate involvement TAK-1...
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a key regulator of low-density lipoprotein (LDL) metabolism involved in the degradation receptor (LDLR) through complex mechanisms. The PCSK9 plasma levels change according to lipid lowering therapy (LLT). Few data exist regarding role vascular damage. We aimed evaluate impact on pulse wave velocity (PWV) and effect inhibitors (PCSK9-i) circulating PWV cohort heterozygous familial hypercholesterolemia (HeFH) subjects. In previous step,...
Background: Systemic sclerosis (SSc) is characterized by early vasculopathy and fibrosis in the skin, lungs, other tissues. Vascular manifestations of SSc include Raynaud’s phenomenon, digital ulcers, pulmonary artery hypertension (PAH). PAH second most common cause mortality SSc. Circulating CD34+ cells associated with cardiovascular health status several conditions, including chronic immune-inflammatory disease. cell numbers have been found inconstantly reduced Endocan, a proteoglycan...
Endocan is a circulating proteoglycan secreted by several cell lines and identified as potential biomarker of inflammation angiogenesis. Endocan-increased expression has been found in broad spectrum human tumors, including lung cancer, associated with poor prognosis. To elucidate the possible mechanism, this study aimed to investigate role endocan non-small-cell carcinoma (NSCLC) using an vitro model cultured cells. was knocked down specific small interfering RNA. The effects knockdown have...
We aimed to describe the limitations of familiar hypercholesterolemia (FH) diagnosis in childhood based on presence typical features FH, such as physical sings cholesterol accumulation and personal or family history premature cardiovascular disease hypercholesterolemia, comparing their prevalence adult paediatric FH population, illustrate how additional information can lead a more effective at younger age.From Italian LIPIGEN cohort, we selected 1188 (≥18 years) 708 (<18...
Hyaluronan (HA) oligosaccharides stimulate pro-inflammatory responses in different cell types by modulating both cluster determinant 44 (CD44) and TLR4. The activation of these receptors is also mediated collagen-induced arthritis (CIA) that, via two pathways, culminates the liberation NF-κB. This then stimulates production cytokines, including IL-18 IL-33, that are greatly involved rheumatoid arthritis. aim this study was to investigate effects 6-mer HA on mouse synovial fibroblasts...