A5087271401- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Pancreatic function and diabetes
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- Advanced Glycation End Products research
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Oral microbiology and periodontitis research
- Pharmaceutical Practices and Patient Outcomes
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Chronic Disease Management Strategies
University of Catania
2016-2025
Ospedale Garibaldi
2012-2025
Azienda Ospedaliera Universitaria Senese
2023
Policlinico S.Orsola-Malpighi
2023
Ospedale San Paolo
2023
IRCCS Ospedale San Raffaele
2023
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2023
Texas Diabetes Institute
2019
The University of Texas Health Science Center at San Antonio
2019
Creative Research Enterprises (United States)
2016
Background: COVID-19 is characterized by severe inflammation during the acute phase and increased aortic stiffness in early postacute phase. In other models, improved after reduction of inflammation. We aimed to evaluate mid- long-term effects on vascular cardiac autonomic function. The primary outcome was pulse wave velocity (aPWV). Methods: cross-sectional Study-1 included 90 individuals with a history 180 matched controls. longitudinal Study-2 41 patients randomly selected from who were...
Statins are a class of drugs widely prescribed as frontline therapy for lowering plasma LDL-cholesterol in cardiovascular risk prevention. Several clinical reports have recently suggested an increased type 2 diabetes associated with chronic use these drugs. The pathophysiology this effect remains to be fully elucidated but impaired β-cell function constitutes potential mechanism. aim study was explore the treatment lipophilic and hydrophilic statins on function, using human pancreatic islets...
In patients with non-alcoholic fatty liver disease (NAFLD), biopsy is the gold standard to detect steatohepatitis (NASH) and stage fibrosis. We aimed identify differentially expressed mRNAs non-coding RNAs in serum samples of biopsy-diagnosed mild severe NAFLD respect controls each other.We first performed a whole transcriptome analysis through microarray (n = 12: four Control: CTRL; NAFLD: NAS ≤ 4 F0; ≥ 5 F3), followed by validation selected transcripts real-time PCRs an independent...
We investigated the role of TG to HDL ratio (TG/HDL) on atherosclerosis extension, defined as presence coronary artery calcium (CAC), carotid and femoral plaque, in prediabetes or newly diagnosed type 2 diabetes (T2D).We performed a retrospective, cross-sectional, single centre study involving 440 controlled T2D subjects. Participants underwent CAC analysis by computed tomography plaque evaluation ultrasonography were stratified high TG/HDL (H-TG/HDL) low (L-TG/HDL) group according median...
The controlling nutritional status (CONUT) score represents poor and has been identified as an indicator of adverse outcomes. Our aim was to evaluate the prognostic role CONUT on in-hospital outcomes in Internal Medicine Department. This is a retrospective study analyzing data from 369 patients, divided into four groups based score: normal (0-1), mild-high (2-4), moderate-high (5-8), marked high (9-12). In-hospital all-cause mortality increased group (2.2% vs. 3.6% 13.4% 15.3%, p < 0.009)....
Abstract Background In the last years, classical pattern of diabetic kidney disease (DKD) has been partially overcome, because uncovering a new DKD phenotype with significant renal dysfunction without presence albuminuria: non-albuminuric (NA-DKD). To date, cardiovascular risk associated this is still debated. We investigated and injury profile NA-DKD subjects in comparison other phenotypes. Methods Pulse wave velocity (PWV), intima-media thickness, carotid atherosclerotic plaque, resistive...
Despite the overall improvement in care, people with type 2 diabetes (T2D) experience an excess risk of end-stage kidney disease. We evaluated long-term effectiveness dapagliflozin on function and albuminuria patients T2D.
Background and aims FH women are less likely to receive intensive statin treatment obtain a 50% reduction of LDL-C from baseline compared men with FH. SLCO1B1 rs4149056 might influence therapy compliance thus target achievement. Our aim was evaluate the impact on achievement after lipid lowering (LLT) optimization in Methods This retrospective observational study involving 412 subjects probable or defined clinical diagnosis who had genetic analysis June 2016 September 2022. Biochemical...
OBJECTIVE We investigated the cardiovascular risk profile in subjects with prediabetes and new-onset type 2 diabetes identified by glycated hemoglobin A1c (HbA1c) according to new American Diabetes Association criteria. RESEARCH DESIGN AND METHODS Arterial stiffness, intima-media thickness (IMT), soluble receptor for advanced glycation end products (sRAGEs), oral glucose tolerance test (OGTT) were evaluated 274 without a previous history of diabetes. The stratified into three groups HbA1c...
Prediabetes is associated with subclinical cardiac changes heart failure development.We investigated diastolic function and its association markers of glycation inflammation related to cardiovascular disease in patients prediabetes. We focused on individuals prediabetes identified only by glycated hemoglobin A1c [HbA1c; 5.7% 6.4% normal fasting glucose (NFG) tolerance (NGT) after an oral test (OGTT)].Cross-sectional study.Departments Clinical Experimental Medicine Cardiology, University...
Background: Proprotein convertase subtilisin kexin type 9 inhibitors (PCSK9i) lower LDL-cholesterol and slow atherosclerosis preventing cardiovascular events. While it is known that circulating PCSK9 enhances platelet activation (PA) PCSK9i reduce it, the underlying mechanism not still clarified. Methods: In a multicenter before–after study in 80 heterozygous familial hypercholesterolemia (HeFH) patients on treatment with maximum tolerated statin dose ± ezetimibe, PA, soluble-NOX2-derived...
The increasing utilization of Glucagon-like Peptide-1 receptor agonists (GLP-1 RAs) in managing type 2 diabetes mellitus has raised interest regarding their impact on thyroid function. In fact, while these agents are well known for efficacy glycemic control and weight management, association with disorders requires clarification due to the complex interplay between hormones metabolic pathways. Thyroid dysfunction commonly co-occurs conditions such as obesity, suggesting a profound...
Abstract Background Familial hypercholesterolemia (FH) is a genetic condition characterized by elevated LDL-C and increased cardiovascular risk. Beyond levels, the impact of genotype on glucose homeostasis has not been well evaluated. We aimed to evaluate glycemic status atherosclerotic injury in FH subjects. Methods conducted cross-sectional study 322 subjects lipid-lowering therapy without history disease. Biochemical analyses as vascular profile assessment were obtained from all The...