A5059481316- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Erythropoietin and Anemia Treatment
- Muscle and Compartmental Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Ion Transport and Channel Regulation
- Renal and Vascular Pathologies
- Heart Failure Treatment and Management
- Electrolyte and hormonal disorders
- Biomedical Research and Pathophysiology
- Nutrition and Health in Aging
- Cardiovascular Function and Risk Factors
- Sepsis Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Potassium and Related Disorders
- Hemoglobinopathies and Related Disorders
- Renal Diseases and Glomerulopathies
- Diabetes Treatment and Management
- Angiogenesis and VEGF in Cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal function and acid-base balance
Magna Graecia University
2014-2025
Dulbecco Telethon Institute
2024
University of Catania
2022-2023
Azienda Ospedaliera Pugliese Ciaccio
2009-2019
Azienda Ospedaliero Universitario Mater Domini
2011-2016
Creative Research Enterprises (United States)
2016
University of Messina
1998-2013
University of Zurich
2013
Institut Curie
2013
Inserm
2013
Background and objectives: Chronic kidney disease (CKD) has recently assumed epidemic proportion, becoming a troubling emerging cause of morbidity, especially if it progresses to terminal stage (ESRD). The authors aimed evaluate whether neutrophil gelatinase-associated lipocalin (NGAL), novel specific biomarker acute injury, could predict the progression CKD. Design, setting, participants, & measurements: Serum urinary NGAL levels, together with series putative factors, were evaluated in...
<i>Background/Aims:</i> Renal tubulointerstitium plays an important role in the development and progression of diabetic nephropathy. <i>Methods:</i> With present study, we aimed at evaluating levels neutrophil gelatinase-associated lipocalin (NGAL), a tubular stress protein, serum (sNGAL) urine (uNGAL) from cohort 56 patients with type 2 diabetes mellitus categorized into three groups (normoalbuminuria, microalbuminuria nephropathy). <i>Results:</i> All...
It is known that many tubular proteins are involved in the pathogenesis of autosomal-dominant polycystic kidney disease (ADPKD), which causes 8-10% cases end-stage renal (ESRD) worldwide. Neutrophil gelatinase-associated lipocalin (NGAL) a protein expressed on cells production markedly increased response to harmful stimuli such as ischemia or toxicity. In present study, serum and urinary NGAL levels were evaluated 26 ADPKD subjects. Both significantly higher patients than controls (sNGAL 174...
Neutrophil gelatinase-associated lipocalin (NGAL) is a small 25-kDa protein released from kidney tubular cells after harmful stimuli. It represents one of the most promising future biomarkers in diagnostic field acute injury (AKI), as increase NGAL levels good predictor brief-term onset AKI, notably anticipating resulting serum creatinine. However, recent studies also suggest possible role for chronic disease (CKD). For this reason we evaluated (sNGAL) and urinary (uNGAL) cohort CKD patients...
Chronic congestive heart failure (CHF) is associated with an increase in cytokines and inflammatory markers, particularly elderly patients whom chronic inflammation generally present per se. In the pilot study, neutrophil gelatinase-associated lipocalin (NGAL), a recently discovered cytokine, was analyzed together different clinical laboratory parameters small cohort of 46 CHF various degrees. NGAL levels were found to be significantly higher than healthy age-balanced controls (458.5...
Reactive oxygen species are major determinants of vascular aging. JunD, a member the activated protein-1 family transcription factors, is emerging as gatekeeper against oxidative stress. However, its contribution to reactive homeostasis in vasculature remains unknown.Endothelium-dependent vasorelaxation was impaired young and old JunD(-/-) mice (6 22 months old) compared with age-matched wild-type mice. displayed an age-independent decline endothelial nitric oxide release synthase activity...
Chronic kidney disease (CKD) is a disorder that causes changes in both the structure and function of kidneys, causing complications such as hypertension, edema, oliguria. Renal fibrosis also common pathological feature CKD. Matrix metalloproteinases (MMPs) are endopeptidases degrade extracellular matrix (ECM) proteins. The proteinase domain consists zinc ion active site, which contributes to its stabilization with another three calcium structural ions. Many cellular processes controlled by...
<i>Background/Aims:</i> Persistent proteinuria is a sign of renal damage caused by several factors, but it itself cause tubular injury leading to chronic failure. Neutrophil gelatinase-associated lipocalin (NGAL) stress protein released cells which urinary excretion (uNGAL) increases in response various stimuli. <i>Methods:</i> In the present study we analyzed uNGAL levels 23 macroproteinuric patients with membranous glomerulonephritis. <i>Results:</i>...
The controlling nutritional status (CONUT) score represents poor and has been identified as an indicator of adverse outcomes. Our aim was to evaluate the prognostic role CONUT on in-hospital outcomes in Internal Medicine Department. This is a retrospective study analyzing data from 369 patients, divided into four groups based score: normal (0-1), mild-high (2-4), moderate-high (5-8), marked high (9-12). In-hospital all-cause mortality increased group (2.2% vs. 3.6% 13.4% 15.3%, p < 0.009)....
This review examines the impact of childhood obesity on kidney from an epidemiological, pathogenetic, clinical, and pathological perspective, with aim providing pediatricians nephrologists most current data this topic. The prevalence chronic disease (CKD) is steadily increasing worldwide, reaching epidemic proportions. While in children CKD less pronounced than adults, recent studies suggest a similar trend child population. likely due to significant association between two leading causes...
Background. The risk of developing cardiovascular diseases is higher in patients on haemodialysis than the general population. These may develop arrhythmias that depend extra- and intracellular concentrations potassium. ECG findings, particularly QT interval its dispersion (QTd) QTc (QT corrected for heart rate according to Bazett's formula) (QTcd), be direct indicators arrhythmia.