A5011804808- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Pharmacological Effects and Toxicity Studies
- Potassium and Related Disorders
- Blood Pressure and Hypertension Studies
- Parathyroid Disorders and Treatments
- Muscle and Compartmental Disorders
- Erythropoietin and Anemia Treatment
- Birth, Development, and Health
- Renal function and acid-base balance
- Vasculitis and related conditions
- Renal Transplantation Outcomes and Treatments
- Diet and metabolism studies
- Neurological Complications and Syndromes
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
- Pediatric Urology and Nephrology Studies
- Organ Donation and Transplantation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hemoglobinopathies and Related Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Magna Graecia University
2012-2021
Azienda Ospedaliero Universitario Mater Domini
1994-2018
Azienda Ospedaliera Pugliese Ciaccio
2016
Creative Research Enterprises (United States)
2016
University of Reggio Calabria
1989-2015
University of Naples Federico II
1985-2015
Sapienza University of Rome
2005-2013
Policlinico Umberto I
2013
Pediatric Nephrology of Alabama
2009
Federico II University Hospital
2005-2006
Previous studies have suggested the benefits of physical exercise for patients on dialysis. We conducted Exercise Introduction to Enhance Performance in Dialysis trial, a 6-month randomized, multicenter trial test whether simple, personalized walking program at home, managed by dialysis staff, improves functional status adult The main study outcomes included change performance 6 months, assessed 6-minute and five times sit-to-stand test, quality life, Kidney Disease Quality Life Short Form...
<b><i>Background/Aims: </i></b>Scarce physical activity predicts shorter survival in dialysis patients. However, the relationship between (motor) fitness and clinical outcomes has never been tested these <b><i>Methods: </i></b>We predictive power of an established metric motor fitness, Six-Minute Walking Test (6MWT), for death, cardiovascular events hospitalization 296 patients who took part trial EXCITE (ClinicalTrials.gov Identifier:...
Rational: Our aim was to investigate the quality of life (QoL) in 103 patients undergoing chronic hemodialysis (HD) an integrated assessment clinical, personological, and adaptation parameters, also a non-urban context.Objectives: We collected data from all HD attending four units. Clinical status assessed by Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines Age-adjusted Charlson Comorbidity Index (ACCI). Patients completed following questionnaires: Life Short Form (KDQOL-SF),...
BackgroundKnowledge on anaemia management in non-dialysis chronic kidney disease (ND-CKD) patients regularly followed renal clinics is scarce although being essential to identifying areas of therapeutic improvement.
Gut dysbiosis has been described in advanced, but not initial stages of CKD. Considering the relevant impact gut on renal and cardiovascular risk, its diagnosis treatment are clinically relevant.
Background. Despite the great prevalence of sleep disorders and low quality in patients with renal diseases, to date no study has evaluated these problems transplant patients.
Nowadays there is a widespread diffusion of mobile applications for weight and diet management. Even though, the most popular apps are not usually experimented in clinical contexts, as well supported by medical evidence. Further research necessary to assess effectiveness Moreover, few examples food recommender systems that provide users nutritional facts about suitable choices take into account individual physiological status environmental situations. We propose DIETOS (DIET Organizer...
Statins increase the production of nitric oxide (NO) and have beneficial effects on course acute renal failure (ARF) in young rats. The a short-term treatment with atorvastatin (ATO) ischemic ARF old rats, characterized by great susceptibility to ischemia, was tested. No difference found dynamics between (Y, 3 mo old) (O, 18 rats normal conditions (CON) or after ATO (12 mg/kg/d for 14 d). Twenty-four hours clamping both arteries, more pronounced decrease GFR observed O versus Y greater...
Objectives Kidney size has been found to be correlated with anthropometric features and kidney function. Therefore, we postulate that if the conventionally measured renal sonographic parameters (pole‐to‐pole length, width, parenchymal thickness) are taken according standardized rules corrected for body height, their association function could strengthened, thus helping validate information a better assessment of chronic disease (CKD) status. Methods This cross‐sectional study included 72...
Erythropoietin has been shown to have a protective effect in certain models of ischaemia-reperfusion, and some cases the protection correlated with activation signalling pathways known play role cell survival proliferation. We studied whether erythropoietin would overcome direct toxic effects hydrogen peroxide (H(2)O(2)) treatment human renal proximal tubular (HK-2) cells.HK-2 cells were incubated H(2)O(2) (2 mm) for 2 h or without at concentrations 100 400 U/ml, viability/proliferation was...
Radiocontrast media (RCM) are widely used in clinical medicine but may lead to radiocontrast-induced nephropathy (RCIN). The pathogenesis of acute renal failure secondary RCM is not fully understood, direct toxic effects believed be a major cause RCIN. We have investigated the effect different types on signaling pathways known play role cell death, survival, and inflammation. HK-2 cells were incubated with sodium diatrizoate iomeprol (IOM) at concentration 75 mg I/ml for 2 h. Both caused an...
Radiocontrast media (RCM)-induced nephrotoxicity (CIN) is a major clinical problem accounting for 12% of all hospital-acquired cases acute kidney injury (AKI). The pathophysiology AKI due to RCM not well understood, but direct toxic effects on renal cells have been postulated as contributing CIN. It believed that iso-osmolar (IOCM) are less nephrotoxic than low-osmolar (LOCM) data controversial. We investigated the intracellular signaling pathways may be affected by LOCM iomeprol (IOM) and...
The small GTPase p21 Ras and its downstream effectors play a central role in the control of cell survival apoptosis. We studied effects Ras/ERK1/2 signaling inhibition on oxidative damage cultured renal endothelial cells ischemia-reperfusion injury rat. Primary human tubular ECV304 underwent significant death when subjected to stress. This type stress induced robustly ERK1/2 phosphoinositide 3-kinase (PI3-kinase) signaling. Inhibition with farnesyl transferase inhibitor, chaetomellic acid A...