A5028011804- Muscle metabolism and nutrition
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Inflammatory Bowel Disease
- Diabetes Treatment and Management
- Renal and Vascular Pathologies
- Electrolyte and hormonal disorders
- Blood Pressure and Hypertension Studies
- Metabolism and Genetic Disorders
- Cardiovascular Disease and Adiposity
- Ion Transport and Channel Regulation
- Renal Diseases and Glomerulopathies
- Cardiovascular Function and Risk Factors
- Renal function and acid-base balance
- Biomarkers in Disease Mechanisms
- Diabetes Management and Research
- Potassium and Related Disorders
- Abdominal vascular conditions and treatments
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Acute Kidney Injury Research
- Cerebrovascular and Carotid Artery Diseases
- Nutritional Studies and Diet
University of Catania
2016-2025
IRCCS Ospedale San Raffaele
2023
Azienda Ospedaliera Universitaria Senese
2023
Policlinico S.Orsola-Malpighi
2023
Ospedale San Paolo
2023
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2023
Policlinico Universitario di Catania
2011-2022
University of Groningen
2022
Université Paris Cité
2016-2017
Assistance Publique – Hôpitaux de Paris
2016-2017
We examined the effect of insulin and plasma amino acid concentrations on leucine kinetics in 15 healthy volunteers (age 22 +/- 2 yr) using euglycemic clamp technique an infusion [1-14C]leucine. Four different experimental conditions were examined: (a) study one, high with reduced concentrations; (b) two, maintenance basal (c) three, elevated (d) four, concentrations. Data analyzed both alpha-ketoisocaproate (the alpha-ketoacid leucine) specific activities. In one total flux, oxidation,...
Previous studies have suggested the benefits of physical exercise for patients on dialysis. We conducted Exercise Introduction to Enhance Performance in Dialysis trial, a 6-month randomized, multicenter trial test whether simple, personalized walking program at home, managed by dialysis staff, improves functional status adult The main study outcomes included change performance 6 months, assessed 6-minute and five times sit-to-stand test, quality life, Kidney Disease Quality Life Short Form...
Background: COVID-19 is characterized by severe inflammation during the acute phase and increased aortic stiffness in early postacute phase. In other models, improved after reduction of inflammation. We aimed to evaluate mid- long-term effects on vascular cardiac autonomic function. The primary outcome was pulse wave velocity (aPWV). Methods: cross-sectional Study-1 included 90 individuals with a history 180 matched controls. longitudinal Study-2 41 patients randomly selected from who were...
Recent studies have reported early atherosclerosis in patients with inflammatory bowel disease (IBD). In these patients, the chronic low-grade inflammation may predispose to vascular remodelling and arterial stiffening. We aimed at studying stiffness IBD patients.Thirty-two without cardiovascular risk factors 32 matched controls were enrolled (age 19-49 years). SphygmoCor device (AtCor Medical, Sydney, Australia) was used measure carotid-femoral carotid-radial (muscular artery) pulse wave...
<b><i>Background/Aims: </i></b>Scarce physical activity predicts shorter survival in dialysis patients. However, the relationship between (motor) fitness and clinical outcomes has never been tested these <b><i>Methods: </i></b>We predictive power of an established metric motor fitness, Six-Minute Walking Test (6MWT), for death, cardiovascular events hospitalization 296 patients who took part trial EXCITE (ClinicalTrials.gov Identifier:...
Background Inflammatory bowel disease ( IBD ) is characterized by a low prevalence of traditional risk factors, an increased aortic pulse-wave velocity aPWV ), and excess cardiovascular events. We have previously hypothesized that the reported in these patients could be explained chronic inflammation. Here, we tested hypothesis inflammation responsible for anti-TNFa (anti-tumor necrosis factor-alpha) therapy reduce patients. Methods Results This was multicenter longitudinal study. enrolled...
The effect of amino acid (AA) infusion on renal hemodynamics was examined in 19 healthy subjects. Thirteen subjects participated the first protocol (normal protein intake) and six second (low intake). consisted three studies: study 1 (n = 13), AA were infused over 3 h to increase plasma levels two- threefold; 2 7), with somatostatin peripheral replacement insulin, glucagon, growth hormone; 6), basal hormonal as 2. During 1, glomerular filtration rate (GFR) rose by 20% (from 107 +/- 5 128 4...
The effect of chronic physiologic hyperglucagonemia on basal and insulin-mediated glucose metabolism was evaluated in normal subjects, using the euglycemic insulin clamp technique (+50, +100, +500 microU/ml). After glucagon infusion fasting increased from 76 +/- 4 to 93 2 mg/dl hepatic production (HGP) rose 1.96 0.08 2.25 mg/kg X min (P less than 0.001). Basal oxidation after 0.05) correlated inversely with decreased free fatty acid concentrations (r = -0.94; P 0.01) lipid -0.75; 0.01)....
Abstract Context: Energy balance and physical activity potentially influence systemic inflammation. Objective: Our objective was to test the hypothesis that moderate energy restriction may prevent activation of inactivity-induced inflammatory response. Design: Participants were studied four times at end 14-d periods experimental bed rest or controlled ambulation, after receiving eucaloric hypocaloric diets. Setting: The study conducted clinical research center German Space Agency. Subjects:...
The effect of insulin on plasma amino acid concentrations and leucine metabolism was examined in 18 healthy nondiabetic young volunteers 7 subjects with insulin-dependent diabetes mellitus (IDDM) the euglycemic insulin-clamp technique (40 mU · m−2 min−1) combination [1-14C]leucine. All diabetic were studied while poor metabolic control (fasting glucose 13.3 ± 1.1 mM; HbA1c 10.8 0.2%) again after 2 mo intensified therapy 7.2 0.5 8.0 0.2%). Insulin-mediated total-body uptake poorly controlled...
Abstract Background In the last years, classical pattern of diabetic kidney disease (DKD) has been partially overcome, because uncovering a new DKD phenotype with significant renal dysfunction without presence albuminuria: non-albuminuric (NA-DKD). To date, cardiovascular risk associated this is still debated. We investigated and injury profile NA-DKD subjects in comparison other phenotypes. Methods Pulse wave velocity (PWV), intima-media thickness, carotid atherosclerotic plaque, resistive...
The effects of hyperinsulinemia and hyperaminoacidemia on glucose amino acid metabolism were examined in 16 control 13 chronic renal failure (CRF) patients under two conditions: 1) euglycemic 2) infusion. All studies performed with continuous indirect calorimetry [1–14C]leucine In CRF insulin-mediated whole body was reduced by 35% (4.41 +/- 0.50 vs. 6.76 0.73 mg.kg-1.min-1, P less than 0.01), primarily due to a decrease nonoxidative disposal (1.70 0.70 4.32 0.60 0.01); oxidation similar both...