A5053575436- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- Herpesvirus Infections and Treatments
- Gastrointestinal disorders and treatments
- Poxvirus research and outbreaks
- Long-Term Effects of COVID-19
- Bacillus and Francisella bacterial research
- Gestational Diabetes Research and Management
- SARS-CoV-2 and COVID-19 Research
- Bone and Joint Diseases
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV/AIDS Impact and Responses
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Bone health and treatments
- Antibiotics Pharmacokinetics and Efficacy
Agostino Gemelli University Polyclinic
1995-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2004-2025
Università Cattolica del Sacro Cuore
2016-2025
University of the Sacred Heart
2007-2023
University of Siena
2018
Magna Graecia University
1996-2016
Catholic University of America
1996-2015
Policlinico Universitario di Catania
2010
Istituto Superiore di Sanità
1997-2004
Ministero della Salute
2004
<h3>Background:</h3> Despite the availability of potent antiretroviral regimens (combination therapy [cART]), HIV-associated neurocognitive disorders (HAND) are increasingly recognized. Our aim was to investigate prevalence and treatment-related correlates HAND, exploring potential neurotoxicity antiretrovirals on cognitive functions. <h3>Methods:</h3> We performed a cross-sectional single cohort study by consecutively enrolling asymptomatic HIV+ subjects during routine outpatient visits....
To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted pregnancy are available. This study aimed evaluate postdischarge SARS-CoV-2 status of mothers COVID-19 that, at birth, were negative SARS-CoV-2. is an observational neonates born disease 2019 (COVID-19). Seven pregnant women documented have been evaluated our institution. One woman had a spontaneous abortion 8 weeks gestational age, four recovered...
Lung ultrasound has been suggested recently by the Chinese Critical Care Ultrasound Study Group and Italian Academy of Thoracic as an accurate tool to detect lung involvement in COVID-19. Although chest computed tomography (CT) represents gold standard assess involvement, with a specificity superior even that nasopharyngeal swab for diagnosis, examination can be valid alternative CT scan, certain advantages, particularly pregnant women. performed directly at bed-side single operator,...
Interleukin-6 signal blockade showed preliminary beneficial effects in treating inflammatory response against SARS-CoV-2 leading to severe respiratory distress. Herein we describe the outcomes of off-label intravenous use Sarilumab SARS-CoV-2-related pneumonia.53 patients with pneumonia received Sarilumab; pulmonary function improvement or Intensive Care Unit (ICU) admission rate medical wards, live discharge ICU treated and safety profile were recorded. 400 mg was administered intravenously...
Objectives The aim of the study was to investigate relationship between metabolic comorbidities, cardiovascular risk factors or common carotid intima‐media thickness ( cIMT ) and cognitive performance in HIV ‐infected patients. Methods Asymptomatic subjects were consecutively enrolled during routine out‐patient visits at two clinical centres. All patients underwent an extensive neuropsychological battery assessment comorbidities factors. Moreover, assessed by ultrasonography. Cognitive...
We describe 10 patients from a large family with early onset motor and sensory neuropathy. Six were still living at the time of study. In all cases, milestones had been achieved. Mean age symptoms was 34 months; these included progressive distal proximal muscle weakness lower limbs. Pes equinovarus developed in during childhood. Slight facial present four patients, one them also bilateral synkinesia. Intellectual function normal cases. There no evidence thickened peripheral nerves. All three...
Summary. Acquired immunodeficiency syndrome (AIDS)‐related primary central nervous system lymphoma (PCNSL) is almost always associated with the Epstein‐Barr virus (EBV), and EBV‐DNA in cerebrospinal fluid (CSF) has been indicated as a useful tumour marker for this HIV‐related neoplasm. AIDS lymphomas also show an enhanced production of IL‐10 which generally presence EBV cells. We performed prospective study 19 HIV seropositive patients brain mass lesions, 21 other or without neurological...
We tested the effects of chloroquine (CQ) on glycosylation HIV particles and in combination with protease inhibitors (PIs) replication P-glycoprotein (P-gp)/multidrug resistance protein-1 (MRP1).CD4 cell lines were infected laboratory strains peripheral blood mononuclear cells primary isolates for evaluation anti-HIV effects. Peripheral lymphocytes evaluated P-gp MRP1 functions.HIV was assessed by enzyme-linked immunosorbent assay. measured metabolic labeling viral [H] glucosamine. Synergism...
Background Growth impairment and bone toxicity due to tenofovir disoproxil fumarate (TDF) fetal exposure has been described mainly in animals. We evaluated growth pattern health TDF-exposed HIV-uninfected children born HIV-infected mothers, defined as seroreverters (SR). Methods This was a multicentre observational cross-sectional cohort study enrolling 68 SR who were utero exposed an antiretroviral regimen including (TDF+) or not (TDF-) tenofovir. Neonatal data duration of recorded. At...
The purpose of this study was to identify the most useful gene for detection biodiversity Pneumocystis carinii hominis isolates and compare samples from French Italian subjects. We studied 20 bronchoalveolar lavage fluid specimens human immunodeficiency virus-infected patients (10 10 patients) with pneumonia by DNA sequencing thymidylate synthase (TS), 5S rRNA, large-subunit mitochondrial rRNA (mt LSU rRNA), internal transcribed spacer (ITS1 ITS2) genes. Thirteen sequenced had prototype TS...
Summary. We evaluated the role of CD34 + bone marrow progenitor cells in vivo, pathogenesis AIDS‐related haematological abnormalities. The clonogenic activity CD34+ from seven patients with HIV‐1 infection, without involving opportunistic infections or neoplasms, was assessed semisolid cultures. number CFU‐GM significantiy reduced as compared to controls (P=0.017). independently myelotoxic therapy, while BFU‐E not. presence retroviral sequences colonies four and total population six advanced...
To explore 48 week safety and efficacy of treatment simplification to atazanavir/ritonavir + lamivudine in HIV-infected patients with virological suppression on a stable atazanavir/ritonavir-based standard triple regimen. This was single-arm pilot study, enrolling 40 two nucleos(t)ide reverse transcriptase inhibitors (NRTIs), without previous failure, HIV-RNA <50 copies/mL for >3 months CD4 >200 cells/mm3. At baseline, were switched 300/100 mg 300 once daily. Laboratory parameters,...
The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing potential for long-term sequelae in these patients. We assessed function cohort patients after recovering infection, stratified according PaO2/FiO2 (p/F) values.Approximately one month hospital discharge, 86 COVID-19 underwent physical examination, arterial blood gas (ABG) analysis, pulmonary tests...
Dengue, traditionally confined to endemic regions, is now emerging in non-endemic areas, including Italy. This manuscript describes the 2023 Italian autochthonous dengue outbreak, reporting clinical and demographic characteristics of 19 patients followed by Fondazione Policlinico Universitario Gemelli IRCCS Rome,
Diagnosis of HIV infection is recently occurring with increasing frequency in middle-aged and older individuals. As HAART became available, a minimal beneficial effect on immunological outcome respect younger subjects has been reported. In fact, both the intensity rapidity response appeared to be reduced elderly subjects. On contrary, only few reports have indicated similar HIV-positive Interestingly, age did not seem significantly affect long-term virological treated subjects.To...
Objective To investigate the efficacy and safety of three regimens for primary prophylaxis Pneumocystis carinii pneumonia (PCP) toxoplasmic encephalitis (TE) to evaluate their effect on survival in patients with HIV infection. Design Randomized, open label, prospective trial. Setting A single Infectious Diseases Department Italy. Patients HIV-infected (n = 197) a CD4 count < 200 × 106/l without previous PCP or TE. Interventions were randomly assigned receive (1) aerosolized pentamidine (AP;...
Aims To compare steady‐state nelfinavir (NFV) pharmacokinetics in pregnant and nonpregnant HIV‐infected women. Methods Twenty‐five women were selected from an ongoing observational study evaluating the of antiretroviral agents during pregnancy. Twenty them third five second trimester. Data for control group 21 taken a previous multicentre pharmacokinetic trial. All participating achieved plasma concentrations while on highly active therapy (HAART) regimen including NFV (1250 mg bid) two...
Radiocontrast media (RCM) are widely used in clinical medicine but may lead to radiocontrast-induced nephropathy (RCIN). The pathogenesis of acute renal failure secondary RCM is not fully understood, direct toxic effects believed be a major cause RCIN. We have investigated the effect different types on signaling pathways known play role cell death, survival, and inflammation. HK-2 cells were incubated with sodium diatrizoate iomeprol (IOM) at concentration 75 mg I/ml for 2 h. Both caused an...