A5026694842- Pancreatic function and diabetes
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diabetes Management and Research
- Diabetes and associated disorders
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Chronic Kidney Disease and Diabetes
- Cardiovascular Disease and Adiposity
- Advanced Glycation End Products research
- Liver Disease and Transplantation
- Frailty in Older Adults
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatitis Pathology and Treatment
- Health Systems, Economic Evaluations, Quality of Life
University of Catania
2016-2025
Ospedale Garibaldi
2016-2025
Azienda Ospedaliera Universitaria Senese
2023
Policlinico S.Orsola-Malpighi
2023
Ospedale San Paolo
2023
IRCCS Ospedale San Raffaele
2023
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2023
University of Palermo
2020-2021
Italian Society of Physiotherapy
2021
Institute for Technologies Applied to Cultural Heritage
2009-2018
In an effort to better understand the phenomenon of lipotoxicity in human β-cells, we evaluated effects 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA) (2:1 oleate palmitate) on function and survival isolated islets investigated some possible mechanisms. Compared control islets, triglyceride content was significantly increased insulin glucose-stimulated release were reduced precultured FFA concentrations. These changes accompanied by a significant reduction glucose utilization...
Human pancreatic islets from eight donors were incubated for 48 h in the presence of 2.0 mmol/l free fatty acid (FFA) (oleate to palmitate, 2 1). Insulin secretion was then assessed response glucose (16.7 mmol/l), arginine (20 and glyburide (200 μmol/l) during static incubation or by perifusion. Glucose oxidation utilization intra-islet triglyceride content measured. The effect metformin (2.4 μg/ml) studied because it protects rat lipotoxicity. Glucose-stimulated but not arginine-...
In rat pancreatic islets chronically exposed to high glucose or free fatty acid (FFA) levels, glucose-induced insulin release and mitochondrial oxidation are impaired. These abnormalities associated with basal ATP levels but a decreased production (Delta of increment over baseline 0.7 +/- 0.5 0.3 pmol/islet in FFA vs. 12.0 0.6 control islets, n = 3; P < 0.01) and, as consequence, an altered ATP/ADP ratio. To investigate further the mechanism impaired formation, we measured glucose-stimulated...
Because metformin affects glucose and free fatty acid (FFA) metabolism in peripheral insulin target tissues, we investigated the effect of this drug restoring a normal secretory pattern rat pancreatic islets whose function has been impaired by chronic exposure to elevated FFA or concentrations. We cultured with without (2 mmol/l oleate/palmitate 2:1) high (16.7 mmol/l) concentrations presence absence (0.25-12.5 microg/ml) then measured release, utilization, glucose, oxidation. When compared...
Statins are a class of drugs widely prescribed as frontline therapy for lowering plasma LDL-cholesterol in cardiovascular risk prevention. Several clinical reports have recently suggested an increased type 2 diabetes associated with chronic use these drugs. The pathophysiology this effect remains to be fully elucidated but impaired β-cell function constitutes potential mechanism. aim study was explore the treatment lipophilic and hydrophilic statins on function, using human pancreatic islets...
In patients with non-alcoholic fatty liver disease (NAFLD), biopsy is the gold standard to detect steatohepatitis (NASH) and stage fibrosis. We aimed identify differentially expressed mRNAs non-coding RNAs in serum samples of biopsy-diagnosed mild severe NAFLD respect controls each other.We first performed a whole transcriptome analysis through microarray (n = 12: four Control: CTRL; NAFLD: NAS ≤ 4 F0; ≥ 5 F3), followed by validation selected transcripts real-time PCRs an independent...
We investigated the role of TG to HDL ratio (TG/HDL) on atherosclerosis extension, defined as presence coronary artery calcium (CAC), carotid and femoral plaque, in prediabetes or newly diagnosed type 2 diabetes (T2D).We performed a retrospective, cross-sectional, single centre study involving 440 controlled T2D subjects. Participants underwent CAC analysis by computed tomography plaque evaluation ultrasonography were stratified high TG/HDL (H-TG/HDL) low (L-TG/HDL) group according median...
The controlling nutritional status (CONUT) score represents poor and has been identified as an indicator of adverse outcomes. Our aim was to evaluate the prognostic role CONUT on in-hospital outcomes in Internal Medicine Department. This is a retrospective study analyzing data from 369 patients, divided into four groups based score: normal (0-1), mild-high (2-4), moderate-high (5-8), marked high (9-12). In-hospital all-cause mortality increased group (2.2% vs. 3.6% 13.4% 15.3%, p < 0.009)....
Despite the overall improvement in care, people with type 2 diabetes (T2D) experience an excess risk of end-stage kidney disease. We evaluated long-term effectiveness dapagliflozin on function and albuminuria patients T2D.
Background and aims FH women are less likely to receive intensive statin treatment obtain a 50% reduction of LDL-C from baseline compared men with FH. SLCO1B1 rs4149056 might influence therapy compliance thus target achievement. Our aim was evaluate the impact on achievement after lipid lowering (LLT) optimization in Methods This retrospective observational study involving 412 subjects probable or defined clinical diagnosis who had genetic analysis June 2016 September 2022. Biochemical...
Abstract Aims The availability of novel lipid-lowering therapies (LLTs) has remarkably changed the clinical management homozygous familial hypercholesterolaemia (HoFH). impact these advances was evaluated in a cohort 139 HoFH patients followed real-world setting. Methods and results characteristics patients, along with information about LLTs low-density lipoprotein cholesterol (LDL-C) levels at baseline after median follow-up 5 years, were retrospectively retrieved from records enrolled...
Type 2 (non–insulin-dependent) diabetes results from decreased insulin action in peripheral target tissues (insulin resistance) and impaired pancreatic β-cell function. These defects reflect both genetic components environmental risk factors. Recently, the common Gly972→Arg amino acid polymorphism of receptor substrate 1 (Arg972 IRS-1) has been associated with human type diabetes. In this study, we report on some functional morphological properties isolated islets carrying Arg972 IRS-1...
OBJECTIVE We investigated the cardiovascular risk profile in subjects with prediabetes and new-onset type 2 diabetes identified by glycated hemoglobin A1c (HbA1c) according to new American Diabetes Association criteria. RESEARCH DESIGN AND METHODS Arterial stiffness, intima-media thickness (IMT), soluble receptor for advanced glycation end products (sRAGEs), oral glucose tolerance test (OGTT) were evaluated 274 without a previous history of diabetes. The stratified into three groups HbA1c...