A5080524604- Diabetes and associated disorders
- Diabetes Management and Research
- Thyroid Cancer Diagnosis and Treatment
- Diet and metabolism studies
- Thyroid and Parathyroid Surgery
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Parathyroid Disorders and Treatments
- Bone health and osteoporosis research
- Bariatric Surgery and Outcomes
- Metabolism, Diabetes, and Cancer
- Bone health and treatments
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Pancreatitis Pathology and Treatment
- Cardiovascular Disease and Adiposity
- Neuroendocrine Tumor Research Advances
- COVID-19 Clinical Research Studies
- Pharmacology and Obesity Treatment
- Obesity and Health Practices
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Head and Neck Anomalies
Università Campus Bio-Medico
2015-2024
Campus Bio Medico University Hospital
2002-2024
Policlinico Umberto I
2022
Advisory Board Company (United States)
2021
CHR Verviers
2021
Diabetes Australia
2018
University of Padua
2017
Regione Lazio
2016
Agenzia Regionale Parchi
2016
Università Cattolica del Sacro Cuore
2006
Abstract Aims To explore variables associated with the serological response following COVID‐19 mRNA vaccine. Methods Eighty‐six healthcare workers adhering to vaccination campaign against were enrolled in January–February 2021. All subjects underwent two vaccine inoculations (Pfizer/BioNTech) separated by 3 weeks. Blood samples collected before 1st and 1–4 weeks after second inoculation. Clinical history, demographics, side effects recorded. Baseline anthropometric parameters measured, body...
An epidemiological retrospective study and a recent prospective from Finland have both concluded that vitamin D3 supplementation at birth protects individuals type 1 diabetes later in life. Moreover, it is thought supplementation, particular its activated form, 1,25-dihydroxyvitamin [1,25-(OH)2D3], may act as an immunomodulator, facilitating the shift Th1 to Th2 immune response. The aim of this surveillance was measure levels 25-hydroxyvitamin (25OHD3) patients with newly diagnosed compared...
OBJECTIVE We investigated whether supplementation of the active form vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed A1C insulin requirement. RESEARCH DESIGN AND METHODS Thirty-four subjects (aged 11–35 years, median 18 years) with high basal >0.25 nmol/l were randomized a double-blind trial to 0.25 μg/day calcitriol or placebo followed-up for 2 years. RESULTS At 6, 12, 24 months follow-up,...
Although there is an evidence of correlation between irisin and osteoporotic fractures, previous studies have not elucidated the relationship either lean or fat mass. The main aim this study to investigate body composition in postmenopausal women with osteoporosis impact levels on fragility vertebral fractures.In cross-sectional study, 36 overweight subjects affected by at least one fracture confirmed X-ray morphometry nonosteoporotic were enrolled. Serum measured using competitive ELISA. We...
Objective Thyroid ultrasound is crucial for clinical decision in the management of thyroid nodules. In this study, we aimed to estimate and compare performance ATA, AACE/ACE/AME ACR TI-RADS classifications discriminating nodules with high-risk cytology. Design Cross-sectional study. Methods 1077 undergoing fine-needle aspiration were classified according by an automated algorithm. Odds ratios (ORs) receiver operating characteristic (ROC) curves cytology categories (TIR3b, TIR4 TIR5)...
Evidence has lately emerged regarding an increased risk of SARS-CoV-2 with worse prognosis in patients obesity, especially among the young. Weight excess is a well-established respiratory disease factor, and newly reported correlation therefore unsurprising. The underlying pathophysiology likely multi-stranded, ranging from complement system hyperactivation, Interleukin-6 secretion, chronic inflammation, presence comorbidities such as diabetes hypertension, possible local, detrimental effect...
Background & AimsNoninvasive assessment of histological features nonalcoholic fatty liver disease (NAFLD) has been an intensive research area over the last decade. Herein, we aimed to develop a simple noninvasive score using routine laboratory tests identify, among individuals at high risk for NAFLD, those with fibrotic steatohepatitis (NASH) defined as NASH, NAFLD activity ≥4, and fibrosis stage ≥2.MethodsThe derivation cohort included 264 morbidly obese undergoing intraoperative biopsy in...
Despite the overall improvement in care, people with type 2 diabetes (T2D) experience an excess risk of end-stage kidney disease. We evaluated long-term effectiveness dapagliflozin on function and albuminuria patients T2D.
Abstract Background A number of recent studies underline the importance vitamin D in pathogenesis Type 1 diabetes (T1D). Aims The aim this study was to investigate whether supplementation with active form (calcitriol) subjects recent‐onset T1D protects residual pancreatic β‐cell function and improves glycaemic control (HbA 1c insulin requirement). Methods In open‐label randomized trial, 70 T1D, mean age 13.6 years ± 7.6 sd were calcitriol (0.25 µg on alternate days) or nicotinamide (25 mg/kg...
ContextDaily parathyroid hormone (PTH) (1–34) administrations can reduce the required total daily dose of calcium and calcitriol restore normocalcemia in refractory hypoparathyroidism. However, most PTH(1–34) trials have been conducted on small cohorts including subjects with hypoparathyroidism various etiologies, quality life (QOL) was not investigated.
No defined pre-treatment factors are able to predict the response radiofrequency ablation (RFA) of an autonomously functioning thyroid nodule (AFTN).Primary endpoint was evaluate success rate RFA restore euthyroidism in a cohort adult patients with small solitary AFTN compared medium-sized nodules. Secondary endpoints included volume reduction and conversion from hot nodules cold using scintiscan.This 24-month prospective monocentric open parallel-group trial. Twenty-nine were divided into...
Background: No direct prospective studies comparing laser ablation (LA) and radiofrequency (RFA) for debulking benign non-functioning thyroid nodules (BNTNs) exist. We aimed at the efficacy safety of both techniques in patients with solid or predominantly BNTN. Methods: This six-month, single-use, randomized, open-label, parallel trial compared following primary endpoints between RFA LA groups six months after treatment: (i) nodule volume reduction expressed as a percentage baseline; (ii)...
Abstract Aim To assess the effect of coronavirus disease 2019 (COVID‐19) lockdown on glycaemic control in subjects with type 2 diabetes (T2D). Materials and Methods In this observational, multicentre, retrospective study conducted Lazio region, Italy, we compared differences HbA1c levels 141 T2D exposed to 123 matched controls who attended centres 1 year before. Basal data were collected from 9 December March follow‐up 3 June 10 July 2020 for group, during same timeframes groups. Changes...
The best nutritional strategy to fight the rise in obesity remains a debated issue. Mediterranean diet (MD) and Very Low-Calorie Ketogenic (VLCKD) are effective at helping people lose body weight (BW) fat mass (FM) while preserving fat-free (FFM). This study aimed evaluate time these two diets took reach loss of 5% initial BW how composition was affected. We randomized 268 subjects with or overweight arms, MD VLCKD, for maximum 3 months until they reached loss. result achieved after one...
Steatotic liver disease (SLD) prevails as the most common chronic yet lack approved treatments due to incomplete understanding of pathogenesis. Recently, elevated hepatic and circulating interleukin 32 (IL-32) levels were found in individuals with severe SLD. However, mechanistic link between IL-32 intracellular triglyceride metabolism remains be elucidated. We demonstrate vitro that incubation IL-32β protein leads an increase synthesis, while downregulation IL32 by small interfering RNA...