A5031667283- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Genetic Syndromes and Imprinting
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Metabolism and Genetic Disorders
- Pituitary Gland Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Thyroid Disorders and Treatments
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Hypothalamic control of reproductive hormones
- Hormonal Regulation and Hypertension
- Diabetes Management and Research
- Amino Acid Enzymes and Metabolism
- Genetics and Neurodevelopmental Disorders
- Hormonal and reproductive studies
- Childhood Cancer Survivors' Quality of Life
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Ovarian function and disorders
- Eicosanoids and Hypertension Pharmacology
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
Bambino Gesù Children's Hospital
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
University of Rome Tor Vergata
2009-2022
Endocrinology Research Center
2018
University of Florence
2017
University of Padua
2017
Boston Children's Hospital
2006-2015
University of Naples Federico II
2015
University of Campania "Luigi Vanvitelli"
2015
Istituto di Sessuologia Clinica
1983-2015
The reliability of provocative stimuli GH secretion in the diagnosis deficiency is still controversial. Until now, normative values response to various have not been established properly. In 472 children and adolescents with normal stature (n = 295, height SDS range -1.5 1.2) or short 177, -3.7 -1.8), we studied physical exercise, insulin-induced hypoglycemia, arginine (ARG), clonidine, levodopa, glucagon, pyridostigmine (PD), GHRH, PD + ARG GHRH. peak responses (range) were: 1) exercise:...
Acute bronchiolitis is the leading cause of lower respiratory tract infection and hospitalization in children less than 1 year age worldwide. It usually a mild disease, but some may develop severe symptoms, requiring hospital admission ventilatory support ICU. Infants with pre-existing risk factors (prematurity, bronchopulmonary dysplasia, congenital heart diseases immunodeficiency) be predisposed to form disease. Clinical diagnosis manly based on medical history physical examination...
OBJECTIVE We investigated whether supplementation of the active form vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed A1C insulin requirement. RESEARCH DESIGN AND METHODS Thirty-four subjects (aged 11–35 years, median 18 years) with high basal >0.25 nmol/l were randomized a double-blind trial to 0.25 μg/day calcitriol or placebo followed-up for 2 years. RESULTS At 6, 12, 24 months follow-up,...
Congenital adrenal hyperplasia (CAH), resulting from mutations in
Objective Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their frequency are scanty, particularly according to the age presentation. Design Observational cohort study carried out between January 2008 June 2016 within national network academic general hospitals. Methods We performed...
Abstract At the end of 2019, an emerging atypical pneumonia called COVID-19 (coronavirus disease 2019), caused by novel coronavirus defined as SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), was first reported. rapidly expanded leading to epidemic in China, followed a global pandemic during year 2020. In few weeks Italy assaulted severe health emergency, constraining Italian government put place extraordinary restrictive measures, such school closures and strict lockdown...
This retrospective study aimed to evaluate children observed for suspected precocious puberty in five Italian centers of Pediatric Endocrinology during the first wave coronavirus disease 2019 pandemic (March-September 2020), compared subjects same period previous year.The population (490 children) was divided according year observation and final diagnosis: transient thelarche, non-progressive puberty, central (CPP), or early puberty.Between March September 2020, 338 were referred 152...
In this study, we report the clinical presentation, response to medical treatment, and long-term follow-up of 26 patients with prolactinoma (15 macro- 11 micro-adenomas) diagnosed at age 7-17 yr. All were first treated bromocriptine (BRC) doses ranging from 2.5-20 mg/day orally. BRC was discontinued for intolerance and/or resistance drug replaced by quinagolide (CV) 0.075-0.6 or cabergoline 0.5-3.5 mg/week Two received external conventional radiotherapy after surgery. 7 prepubertal males 6...
We have evaluated the plasma GH response to a single injection of 1 microgram/kg GH-releasing hormone (GHRH)-40 in 15 obese children and age-matched control children. Most showed subnormal GHRH mean integrated area (IC-GH) following stimulation was significantly smaller than Plasma somatomedin-C (SM-C) levels were higher children, negatively correlated with peak (r = -0.616, P less 0.01) IC-GH -0.554, 0.02) after GHRH. Non-esterified fatty acids (NEFA) fasting insulin also elevated but did...
Heterozygous inactivating mutations in the Gsα gene cause Albright's hereditary osteodystrophy. Consistent with observation that only maternally inherited lead to resistance hormone action [pseudohypoparathyroidism type Ia (PHP Ia)], recent studies provided evidence for a predominant maternal origin of transcripts endocrine organs, such as thyroid, gonad, and pituitary. The aim this study was investigate presence pituitary hypothalamic hormones acting via Gsα-coupled receptors patients PHP...
A study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. The results showed that administration a combination two acids (1200 mg 1-lysine plus 1200 1-arginine) provoked release pituitary somatotropin and insulin. This phenomenon reproducible hormone secreted response this had biological activity (as demonstrated radioreceptor assay somatomedin induction). effect appeared be specific acids; neither...
The two major autoimmune thyroid diseases (ATDs) include Graves' disease (GD) and thyroiditis (AT); both of which are characterized by infiltration the T B cells reactive to antigens, production autoantibodies abnormal function (hyperthyroidism in GD hypothyroidism AT). While exact etiology autoimmunity is not known, it believed develop when a combination genetic susceptibility environmental encounters leads breakdown tolerance. It important recognize dysfunction at an early stage...
The natural history of Hashimoto's thyroiditis (HT) and isolated hyperthyrotropinaemia (IH) is not well defined. We therefore studied the course patients with HT IH looked for possible prognostic factors. This retrospective cross-sectional study. Three hundred twenty-three (88 boys 235 girls) 59 (30 29 girls), mean age 9·9 ± 3·8 years were included in When first examined, 236 children had a normal TSH (G0) 87, it was elevated but <100% upper limit (G1). All subjects TSH. Potential risk...
Context:It is still controversial whether all girls with central precocious puberty (CPP) should undergo brain magnetic resonance imaging (MRI) for unveiling intracranial pathology.
A defect in indoleamine 2,3-dioxygenase 1 (IDO1), which is responsible for immunoregulatory tryptophan catabolism, impairs development of immune tolerance to autoantigens NOD mice, a model human autoimmune type diabetes (T1D). Whether IDO1 function also defective T1D still unknown. We investigated sera and peripheral blood mononuclear cells (PBMCs) from children with matched controls. These were further included discovery study identify SNPs that might modify the risk T1D. was characterized...