Tony Huynh
A5054501308- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Muscle Physiology and Disorders
- Sexual Differentiation and Disorders
- Thyroid Disorders and Treatments
- Neuroblastoma Research and Treatments
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Growth Hormone and Insulin-like Growth Factors
- Vitamin D Research Studies
- Exercise and Physiological Responses
- Cancer therapeutics and mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics and Neurodevelopmental Disorders
- Acute Myeloid Leukemia Research
- Paleontology and Evolutionary Biology
- Salivary Gland Disorders and Functions
- Blood groups and transfusion
- Blood disorders and treatments
- Urological Disorders and Treatments
- Diet and metabolism studies
- Neonatal Respiratory Health Research
- Adrenal Hormones and Disorders
Mater Health Services
2015-2025
Queensland Children’s Hospital
2016-2025
The University of Queensland
2017-2025
Université Paris Cité
2023-2024
Tra Vinh University
2024
Children's Medical Research Institute
2023-2024
Hôpital Saint-Louis
2023-2024
Assistance Publique – Hôpitaux de Paris
2023-2024
Mater Children's Hospital
2008-2020
The University of Melbourne
2020
Disorders of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or phenotypic is atypical. Clinical management DSD often difficult and currently only 13% patients receive an accurate clinical genetic diagnosis. To address this we have developed a massively parallel sequencing targeted gene panel allows us to sequence all 64 known diagnostic genes candidate simultaneously. We analyzed DNA from the largest reported international cohort with (278 46,XY 48 46,XX DSD)....
Inclusion of continuous glucose monitoring (CGM) targets for children, adolescents, and young adults <25 years. Adoption a unified fingerstick capillary (SMBG) target between 4 10 mmol/L (70–180 mg/dl), which aligns with the CGM time in range (TIR), while emphasizing tighter fasting 4–8 (70–144 mg/dl). Recognition that disparities social determinants health (SDOH) inequitable access to modern diabetes therapies represent significant barriers achieving optimizing clinical outcomes. Health...
Absence of dystrophin makes skeletal muscle more susceptible to injury, resulting in breaches the plasma membrane and chronic inflammation Duchenne muscular dystrophy (DMD).Current management by glucocorticoids has unclear molecular benefits harsh side effects.It is uncertain whether therapies that avoid hormonal stunting growth development, and/or immunosuppression, would be or less beneficial.Here, we discover an oral drug with mechanisms provide efficacy through anti-inflammatory...
Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is the most prevalent cause of liver disease worldwide, with a single approved therapeutic. Previous research has shown that interleukin-22 (IL-22) can suppress β-cell stress, reduce local islet inflammation, restore appropriate insulin production, reverse hyperglycemia, and ameliorate resistance in preclinical models diabetes. In clinical trials long-acting forms IL-22 have led to increased proliferation skin intestine, where...
OBJECTIVE To compare demographic, clinical, and therapeutic characteristics of children with type 1 diabetes age &lt;6 years across three international registries: Diabetes Prospective Follow-Up Registry (DPV; Europe), T1D Exchange Quality Improvement Network (T1DX-QI; U.S.), Australasian Data (ADDN; Australasia). RESEARCH DESIGN AND METHODS An analysis was conducted comparing 2019–2021 prospective registry data from 8,004 children. RESULTS Mean ± SD ages at diagnosis were 3.2 1.4 (DPV...
OBJECTIVE Technology use in type 1 diabetes (T1D) is impacted by socioeconomic status (SES). This analysis explored relationships between SES, glycemic outcomes, and technology use. RESEARCH DESIGN AND METHODS A cross-sectional of HbA1c data from 2,822 Australian youth with T1D was undertaken. Residential postcodes were used to assign SES based on the Index Relative Socio-Economic Disadvantage (IRSD). Linear regression models evaluate associations among IRSD quintile, HbA1c, management...
<title>Abstract</title> The gut microbiomes of traditional Indigenous and 'Western' societies differ markedly in diversity composition. Western diet modifies the microbiome, promoting cardiometabolic disorders that disproportionately affect Australians. Studies are underrepresented literature comparative studies young children living lacking, limiting our understanding early-life microbiome development different cultural contexts. Therefore, we analyzed metagenomes 50 Australian infants...
Continuous glucose monitoring (CGM) can detect early dysglycemia in older children and adults with presymptomatic type 1 diabetes (T1D) predict risk of progression to clinical onset. However, CGM data for very young at greatest disease are lacking. This study aimed investigate the use measured being longitudinally observed Australian Environmental Determinants Islet Autoimmunity (ENDIA) from birth age 10 years.
Type1Screen offers islet autoantibody testing to Australians with a family history of type 1 diabetes (T1D) the dual aims preventing diabetic ketoacidosis (DKA) and enabling use disease-modifying therapy. We describe screening monitoring outcomes 2 years after implementing in-home capillary blood spot sampling. Data from 2,064 participants who registered between July 2022 June 2024 were analyzed: 1,507 557 chose venipuncture respectively. compared baseline characteristics for 1,243 (967 276...
<p dir="ltr">Objective Type1Screen offers islet autoantibody testing to Australians with a family history of type 1 diabetes (T1D) the dual aims preventing diabetic ketoacidosis (DKA) and enabling use disease-modifying therapy. We describe screening monitoring outcomes two years after implementing in-home capillary blood spot sampling. Research design methods Data from 2064 participants who registered between July 2022 June 2024 were analyzed: 1507 557 chose venipuncture respectively....
<p dir="ltr">Objective Type1Screen offers islet autoantibody testing to Australians with a family history of type 1 diabetes (T1D) the dual aims preventing diabetic ketoacidosis (DKA) and enabling use disease-modifying therapy. We describe screening monitoring outcomes two years after implementing in-home capillary blood spot sampling. Research design methods Data from 2064 participants who registered between July 2022 June 2024 were analyzed: 1507 557 chose venipuncture respectively....
This cohort study examines whether there is a temporal association between SARS-CoV-2 infection and the development of islet autoimmunity among Australian children with first-degree relative type 1 diabetes.
Abstract Predicting and quantifying phenotypic consequences of genetic variants in rare disorders is a major challenge, particularly pertinent for ‘actionable’ genes such as thyroid hormone transporter MCT8 (encoded by the X-linked SLC16A2 gene), where loss-of-function (LoF) cause neurodevelopmental (treatable) metabolic disorder males. The combination deep phenotyping data with functional computational tests outcomes population cohorts, enabled us to: (i) identify aetiology divergent...
Introduction: Physical activity has health benefits for people living with type 1 diabetes (T1D), however there are barriers limiting their ability to meet minimum recommended levels of moderate-to-vigorous-physical-activity (MVPA). We aimed measure physical and in children < 7 years age T1D compare general population data guidelines. Methods: Children were recruited from two paediatric centres Australia. was measured days using an accelerometer. Parents completed questionnaires related...
Abstract Context Patients with mutations in thyroid hormone transporter MCT8 have developmental delay and chronic thyrotoxicosis associated being underweight having cardiovascular dysfunction. Objective Our previous trial showed improvement of key clinical biochemical features during 1-year treatment the T3 analogue Triac, but long-term follow-up data are needed. Methods In this real-life retrospective cohort study, we investigated efficacy Triac MCT8-deficient patients 33 sites. The primary...
Resistance to cytotoxic drugs is thought be a major cause of treatment failure in childhood neuroblastoma, and members the ATP-binding cassette (ABC) transporter superfamily may contribute this phenomenon by active efflux chemotherapeutic agents from cancer cells. As member C subfamily ABC transporters, multidrug resistance-associated protein MRP4/ABCC4 has ability export variety endogenous exogenous substances across plasma membrane. In light its capacity for drug efflux, MRP4 been studied...
Introduction Congenital muscular dystrophy is a distinct group of diseases presenting with weakness in infancy or childhood and no current therapy. One form, MDC1A, the result laminin alpha-2 deficiency results significant weakness, respiratory insufficiency early death. Modification apoptosis one potential pathway for therapy these patients. Methods dy2J mice were treated vehicle, 0.1 mg/kg 1 omigapil daily via oral gavage over 17.5 weeks. Untreated age matched BL6 used as controls....
Hypertension increases complication risk in type 1 diabetes (T1D). We examined blood pressure (BP) adolescents and young adults with T1D from the Australasian Diabetes Data Network, a prospective clinical registry Australia New Zealand.This was longitudinal study of prospectively collected data.T1D (duration ≥ year) age 16-25 years at last visit (2011-2020). defined as (on 3 occasions) systolic BP and/or diastolic > 95th percentile for < 18 years, 130 80 mmHg years. Multivariable Generalised...
Abstract Type 1 diabetes (T1D) is well-recognised as a continuum heralded by the development of islet autoantibodies, progression to autoimmunity causing beta cell destruction, culminating in insulin deficiency and clinical disease. Abnormalities glucose homeostasis are known exist well before onset typical symptoms. Laboratory-based tests such oral tolerance test (OGTT) glycated haemoglobin (HbA 1c ) have been used stage T1D assess risk T1D. Continuous monitoring (CGM) can detect early...
Introduction The Environmental Determinants of Islet Autoimmunity (ENDIA) Study is an ongoing Australian prospective cohort study investigating how modifiable prenatal and early-life exposures drive the development islet autoimmunity type 1 diabetes (T1D) in children. In this profile, we describe cohort’s parental demographics, maternal neonatal outcomes human leukocyte antigen (HLA) genotypes. Research design methods Inclusion criteria were unborn child, or infant aged less than 6 months,...