A5066916142- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Education
- Chronic Disease Management Strategies
- Diabetes Treatment and Management
- Wireless Networks and Protocols
- Childhood Cancer Survivors' Quality of Life
- Child and Adolescent Health
- Mobile Health and mHealth Applications
- Genetic Syndromes and Imprinting
- FOXO transcription factor regulation
- Parkinson's Disease Mechanisms and Treatments
- Genomics and Rare Diseases
- Receptor Mechanisms and Signaling
- Pharmacological Effects and Assays
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nutrition and Health in Aging
- COVID-19 Clinical Research Studies
- Neurological Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Saffron Plant Research Studies
- Essential Oils and Antimicrobial Activity
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
Children's Hospital of Los Angeles
2014-2025
University of Southern California
2017-2024
University of California, Irvine
1991
Health care inequities among racial and ethnic groups remain prevalent. For people with type 1 diabetes who require increased medical access care, disparities are seen in to health outcomes. This article reports on a study by the T1D Exchange Quality Improvement Collaborative evaluating differences A1C, diabetic ketoacidosis (DKA), severe hypoglycemia, technology use groups. In diverse cohort of nearly 20,000 children adults diabetes, A1C was found differ significantly Non-Hispanic Blacks...
Aging is influenced by endocrine pathways including the growth hormone/insulin-like factor-1 (GH/IGF) axis. Mitochondrial function has also been linked to aging process, but relevant mitochondrial signals mediating effects of mitochondria are poorly understood. Humanin a novel signaling peptide that acts as potent regulator cellular stress responses and protects from variety in vitro vivo toxic metabolic insults. The circulating levels humanin decline with age mice humans. Here, we...
OBJECTIVE To evaluate the contemporary prevalence of diabetic peripheral neuropathy (DPN) in participants with type 1 diabetes T1D Exchange Clinic Registry throughout U.S. RESEARCH DESIGN AND METHODS DPN was assessed Michigan Neuropathy Screening Instrument Questionnaire (MNSIQ) adults ≥5 years duration. A score ≥4 defined DPN. Associations demographic, clinical, and laboratory factors were assessed. RESULTS Among 5,936 (mean ± SD age 39 18 years, median duration [interquartile range 11,...
This large type 1 diabetes cohort study showed that insulin pump utilization has increased over time and use differs by sex, insurance type, race/ethnicity. Insulin was associated with more optimal A1C, of continuous glucose monitoring (CGM), lower rates diabetic ketoacidosis severe hypoglycemia. People who used an CGM had acute events than their counterparts without CGM. These findings highlight the need to improve access technology through provider engagement, multidisciplinary approaches,...
OBJECTIVE To compare demographic, clinical, and therapeutic characteristics of children with type 1 diabetes age <6 years across three international registries: Diabetes Prospective Follow-Up Registry (DPV; Europe), T1D Exchange Quality Improvement Network (T1DX-QI; U.S.), Australasian Data (ADDN; Australasia). RESEARCH DESIGN AND METHODS An analysis was conducted comparing 2019–2021 prospective registry data from 8,004 children. RESULTS Mean ± SD ages at diagnosis were 3.2 1.4 (DPV...
<p dir="ltr">Objective</p><p dir="ltr">Early initiation of continuous glucose monitor (CGM) after type 1 diabetes diagnosis has been associated with lower hemoglobin A1c (HbA1c) in single-institution studies. This multi-center study evaluated the association between timing CGM and HbA1c at 3 years post-diagnosis.</p><p><br></p><p dir="ltr">Research Design Methods</p><p dir="ltr">Data were obtained from T1D Exchange Quality...
OBJECTIVE Early initiation of continuous glucose monitor (CGM) after type 1 diabetes (T1D) diagnosis has been associated with lower hemoglobin A1C (HbA1c) in single-institution studies. This multicenter study evaluated the association between timing CGM and HbA1c at 3 years postdiagnosis. RESEARCH DESIGN AND METHODS Data were obtained from T1D Exchange Quality Improvement Collaborative (T1DX-QI) electronic health record database 25 pediatric centers included children adolescents ≤18 old...
<p dir="ltr">Objective</p><p dir="ltr">Early initiation of continuous glucose monitor (CGM) after type 1 diabetes diagnosis has been associated with lower hemoglobin A1c (HbA1c) in single-institution studies. This multi-center study evaluated the association between timing CGM and HbA1c at 3 years post-diagnosis.</p><p><br></p><p dir="ltr">Research Design Methods</p><p dir="ltr">Data were obtained from T1D Exchange Quality...
This article describes how the T1D Exchange Quality Improvement Collaborative leverages an innovative web platform, QI Portal, to gather and store electronic medical record (EMR) data promote benchmarking population health improvement in a type 1 diabetes learning system. The authors explain value of process for mapping center-level from EMRs using standardized specifications, Portal’s unique features advancing health.
The American Diabetes Association’s Standards of Care in recommends the use diabetes technology such as continuous glucose monitoring systems and insulin pumps for people living with type 1 diabetes. Unfortunately, there are multiple barriers to uptake these devices, including local center practices. This study aimed examine overall change center-to-center variation across 21 pediatric centers T1D Exchange Quality Improvement Collaborative. It found an increase most from 2021 2022...
Abstract Objectives To determine changes in case rates of youth onset type 2 diabetes the three years following COVID-19 pandemic. Methods A single-center, retrospective medical record review was conducted for patients newly diagnosed with T2D between 3/1/18 and 2/28/23 at a pediatric tertiary care center. The number referred to CHLA diagnosis date 3/1/2020 2/28/2023 compared historical 3/1/2018 2/29/2020. χ or Fisher’s exact test used compare categorical variables each year 2019. Results...
Background: Systematic and comprehensive data acquisition from the electronic health record (EHR) is critical to quality of used improve patient care. We described EHR tools, workflows, elements that contribute core metrics in Type 1 Diabetes Exchange Quality Improvement Collaborative (T1DX-QI). Method: conducted interviews with improvement (QI) representatives at 13 T1DX-QI centers about their clinic elements. Results: All had access structured nine questionnaires two integration a device...
There are currently no published cases that report concomitant Turner syndrome (TS), 2q37 deletion and X-linked hypophosphatemic rickets (XLH).Interestingly, since the clinical phenotypes of TS overlap, correct diagnosis may be missed without a standardized approach to genetic testing consisting both karyotype microarray.Both chromosome anomalies have been associated with short stature variety skeletal abnormalities however date reports these syndromes in association phosphate regulating...
<p dir="ltr">Children’s Hospital Los Angeles (CHLA) is a large, urban tertiary care pediatric hospital that receives referrals from southern California. CHLA provides to ~1,800 children and youth with type 1 diabetes. The patient population diverse in terms of race/ethnicity socioeconomic status (58% publicly insured; 26% identify as White, 3% Asian, 5% Black, 30% Hispanic). English Spanish are the most common spoken languages at home (85 12%, respectively).</p>
<p dir="ltr">Children’s Hospital Los Angeles (CHLA) is a large, urban tertiary care pediatric hospital that receives referrals from southern California. CHLA provides to ~1,800 children and youth with type 1 diabetes. The patient population diverse in terms of race/ethnicity socioeconomic status (58% publicly insured; 26% identify as White, 3% Asian, 5% Black, 30% Hispanic). English Spanish are the most common spoken languages at home (85 12%, respectively).</p>
Quality Improvement Success Stories are published by the American Diabetes Association in collaboration with College of Physicians and National Education Program. This series is intended to highlight best practices strategies from programs clinics that have successfully improved quality care for people diabetes or related conditions. Each article reviewed follows a standard format developed editors Clinical Diabetes. The following describes improvement initiative reduce barriers insulin pump...
Health insurance coverage type differs significantly by socioeconomic status and racial group in the United States. The aim of this study was to determine whether publicly insured children young adults with 1 diabetes were more likely experience adverse outcomes compared privately patients acute coronavirus disease 2019 (COVID-19) infections.Data from 619 previously established who <24 years age COVID-19 infections analyzed T1D Exchange surveillance registry. Data for registry collected 52...
Background: Continuous glucose monitor (CGM) usage improves glycemia in people with type 1 diabetes (PWD) and is accepted as the standard of care. The CGM utilization lower patients public insurance minorized ethnicities. In 2022, California Medicaid reduced its barriers to obtaining coverage for PWD. It unknown whether this policy change sufficient increase usage. We hypothesize that improved uptake children young adults T1D. Methods: Data were extracted from electronic medical record a...