A5048803065- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Glycogen Storage Diseases and Myoclonus
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism and Genetic Disorders
- Lysosomal Storage Disorders Research
- Carbohydrate Chemistry and Synthesis
- Genetics and Neurodevelopmental Disorders
- Diabetes Management and Education
- Adolescent and Pediatric Healthcare
- Diabetes Treatment and Management
- Oral and gingival health research
- Blood disorders and treatments
- Neonatal Health and Biochemistry
- Clinical Nutrition and Gastroenterology
- Childhood Cancer Survivors' Quality of Life
- Thyroid Disorders and Treatments
- Digestive system and related health
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Diet, Metabolism, and Disease
- Genomics and Rare Diseases
- Biomedical Research and Pathophysiology
Harvard University
2015-2025
Boston Children's Hospital
2016-2025
Boston University
1982-2022
Joslin Diabetes Center
1986-2020
Endocrinology Research Center
2020
Boston Children's Museum
2002-2019
Children's Hospital
2005-2019
Lemuel Shattuck Hospital
2010
University of Florida
2001-2009
Florida College
2009
It is unknown whether insulin therapy can delay or prevent diabetes in nondiabetic relatives of patients with diabetes.
OBJECTIVE—This randomized, double-masked, placebo-controlled clinical trial tested whether oral insulin administration could delay or prevent type 1 diabetes in nondiabetic relatives at risk for diabetes. RESEARCH DESIGN AND METHODS—We screened 103,391 first- and second-degree of patients with analyzed 97,273 samples islet cell antibodies. A total 3,483 were antibody positive; 2,523 underwent genetic, immunological, metabolic staging to quantify developing diabetes; 388 had a 5-year...
During the first 24-48 hours of life, as normal neonates transition from intrauterine to extrauterine their plasma glucose (PG) concentrations are typically lower than later in life.1Cornblath M. Reisner S.H. Blood neonate and its clinical significance.N Engl J Med. 1965; 273: 378-381Crossref PubMed Scopus (116) Google Scholar, 2Srinivasan G. Pildes R.S. Cattamanchi Voora S. Lilien L.D. Plasma values neonates: a new look.J Pediatr. 1986; 109: 114-117Abstract Full Text PDF (225) 3Stanley C.A....
Table 1
he adage "A child is not a miniature adult" most appropriate when considering diabetic ketoacidosis (DKA).The fundamental pathophysiology of this potentially life-threatening complication the same as in adults.However, differs from adult number characteristics.1) The younger child, more difficult it to obtain classical history polyuria, polydipsia, and weight loss.Infants toddlers DKA may be misdiagnosed having pneumonia, reactive airways disease (asthma), or bronchiolitis therefore treated...
The adage “A child is not a miniature adult” most appropriate when considering diabetic ketoacidosis (DKA). fundamental pathophysiology of this potentially life-threatening complication the same as in adults. However, differs from adult number characteristics. 1 ) younger child, more difficult it to obtain classical history polyuria, polydipsia, and weight loss. Infants toddlers DKA may be misdiagnosed having pneumonia, reactive airways disease (asthma), or bronchiolitis therefore treated...
Severe hypoglycemia (SH) and diabetic ketoacidosis (DKA) are common serious acute complications of type 1 diabetes (T1D). The aim this study was to determine the frequency SH DKA identify factors related their occurrence in T1D Exchange pediatric young adult cohort.
Hypoglycemia in people with diabetes is common, especially those taking medications such as insulin and sulfonylureas (SU) that place them at higher risk. associated distress their families, medication nonadherence, disruption of life work, it leads to costly emergency department visits hospitalizations, morbidity, mortality.To review update the diabetes-specific parts 2009 Evaluation Management Adult Hypoglycemic Disorders: Endocrine Society Clinical Practice Guideline address developing...
Clinically apparent cerebral edema is a rare and often fatal complication of diabetic ketoacidosis. To determine whether subclinical brain swelling occurs more commonly, we obtained cranial CT scans in six children with ketoacidosis treated fluid resuscitation continuous low-dose insulin therapy. Control were before hospital discharge. Compared the during convalescence, early all showed narrowing brain's ventricular system, compatible swelling. Average changes diameter 1.3 +/- 0.1 mm for...
Cross-sectional and longitudingal findings drawn from a 4-year longitudinal study of an onset cohort preadolescents early adolescents with insulin-dependent diabetes their families are presented. Patient parent perceptions the familiy environment near time diagnosis used to examine patterns adherence in first year illness as well over four follow-up years. We found that family conflict, cohesion, organization were strongly associated independently rated first-year levels. The strongest...
An onset cohort of children and adolescents with insulin-dependent diabetes mellitus (IDDM) their parents were studied. Aspects family environment evaluated at study inception, influence on the initial level of, change in, glycemic control over 4 years was examined. Family measures expressiveness, cohesiveness, conflict linked to differences in longitudinal pattern control. In particular, encouragement act openly express feelings directly (expressiveness) seemed ameliorate deterioration time...
OBJECTIVE To examine characteristics of the transition from pediatric to adult care in emerging adults with type 1 diabetes and evaluate associations between glycemic control. RESEARCH DESIGN AND METHODS We developed mailed a survey process diabetes, aged 22 30 years, receiving at single center. Current A1C data were obtained medical record. RESULTS The response rate was 53% (258 484 eligible). mean age 19.5 ± 2.9 34% reported gap >6 months establishing care. Common reasons for...
TrialNet's goal to test preventions for type 1 diabetes has created an opportunity gain new insights into the natural history of pre-type diabetes. The TrialNet Natural History Study (NHS) will assess predictive value existing and novel risk markers find subjects prevention trials.The NHS is a three-phase, prospective cohort study. In phase (screening), pancreatic autoantibodies (glutamic acid decarboxylase, insulin, ICA-512, islet cell antibodies) are measured. Phase 2 (baseline assessment)...
An onset cohort of adolescents and children with insulin-dependent diabetes mellitus was studied over a 4-year period. Individual patient psychosocial demographic factors were assessed at study inception used to examine aspects adherence the follow-up. We found that initial assessment coping (defense level, adaptive strength, locus control) adjustment predictive level diabetic regimen 4 years study. Psychosocial variables predicted outcomes independent age. This for three domains adherence,...