Roshanak Monzavi
A5007120737- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Childhood Cancer Survivors' Quality of Life
- Child and Adolescent Health
- Diabetes Treatment and Management
- Adolescent and Pediatric Healthcare
- Genetic Syndromes and Imprinting
- Pituitary Gland Disorders and Treatments
- Chronic Disease Management Strategies
- Innovations in Medical Education
- Growth Hormone and Insulin-like Growth Factors
- Obesity, Physical Activity, Diet
- Obesity and Health Practices
- Prion Diseases and Protein Misfolding
- Health and Medical Research Impacts
- Vitamin C and Antioxidants Research
- Parkinson's Disease Mechanisms and Treatments
- Electrolyte and hormonal disorders
- Adrenal Hormones and Disorders
- Vitamin D Research Studies
- Stress Responses and Cortisol
- Child Nutrition and Feeding Issues
- Advanced Glycation End Products research
- Botulinum Toxin and Related Neurological Disorders
Children's Hospital of Los Angeles
2011-2024
University of Southern California
2011-2021
Benaroya Research Institute
2018
Southern California University for Professional Studies
2011-2015
Boston Children's Hospital
2003
Mattel Children's Hospital
2002
University of California, Irvine
1994
Adolescents and young adults with type 1 diabetes exhibit the worst glycemic control among individuals across lifespan. Although continuous glucose monitoring (CGM) has been shown to improve in adults, its benefit adolescents not demonstrated.To determine effect of CGM on diabetes.Randomized clinical trial conducted between January 2018 May 2019 at 14 endocrinology practices US including 153 aged 24 years screening hemoglobin A1c (HbA1c) 7.5% 10.9%.Participants were randomized 1:1 undergo...
BACKGROUND. Type 1 diabetes (T1D) results from destruction of pancreatic β cells by autoreactive effector T cells. We hypothesized that the immunomodulatory drug alefacept would result in targeted quantitative and qualitative changes prolonged preservation endogenous insulin secretion remaining patients with newly diagnosed T1D.
OBJECTIVE We previously reported that 2 years of costimulation modulation with abatacept slowed decline β-cell function in recent-onset type 1 diabetes (T1D). Subsequently, was discontinued and subjects were followed to determine whether there persistence effect. RESEARCH DESIGN AND METHODS Of 112 (ages 6-36 years) T1D, 77 received 35 placebo infusions intravenously for 27 over years. The primary outcome-baseline-adjusted geometric mean 2-h area under the curve (AUC) serum C-peptide during a...
OBJECTIVE A pilot study suggested that combination therapy with low-dose anti-thymocyte globulin (ATG) and pegylated granulocyte colony-stimulating factor (GCSF) preserves C-peptide in established type 1 diabetes (T1D) (duration 4 months to 2 years). We hypothesized 1) ATG/GCSF or 2) ATG alone would slow the decline of β-cell function patients new-onset T1D <100 days). RESEARCH DESIGN AND METHODS three-arm, randomized, double-masked, placebo-controlled trial was performed by Type...
OBJECTIVE. To evaluate the prevalence of risk factors that are associated with metabolic syndrome and insulin resistance in overweight youth to determine effect a short-term, family-centered, lifestyle intervention on various anthropometric measures. METHODS. Overweight who were between 8 16 years age participated 12-week, program. Anthropometric measures assessed before program all participants (n = 109) after subset 43). RESULTS. At baseline, 49.5% had multiple syndrome, based modified...
OBJECTIVE To evaluate the contemporary prevalence of diabetic peripheral neuropathy (DPN) in participants with type 1 diabetes T1D Exchange Clinic Registry throughout U.S. RESEARCH DESIGN AND METHODS DPN was assessed Michigan Neuropathy Screening Instrument Questionnaire (MNSIQ) adults ≥5 years duration. A score ≥4 defined DPN. Associations demographic, clinical, and laboratory factors were assessed. RESULTS Among 5,936 (mean ± SD age 39 18 years, median duration [interquartile range 11,...
Objective Little is known about the relationship between vitamin D deficiency and adolescents with type 1 diabetes. On basis of adult studies showing that improves insulin sensitivity decreases inflammatory cytokines linked to microvascular complications, we hypothesized treating in diabetes would improve glycemia reduce markers. Research design methods This was a randomized, prospective, crossover study 25 for at least year (aged: 13–21 yr; 62% female; Hispanic) (25-OH ≤30 ng/mL). Subjects...
To develop and validate new measures of diabetes-specific health-related quality life (HRQOL) for people with type 1 diabetes (T1D) that are brief, developmentally appropriate, usable in clinical research care. Here we report on the phases developing validating self-report Type Diabetes Life (T1DAL) children (age 8-11) adolescents 12-17).Measure development included qualitative interviews youth parents (n = 16 dyads) followed by piloting draft conducting cognitive debriefing 9) to refine...
OBJECTIVE Innate immune responses may be involved in the earliest phases of type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS To test whether blocking innate immaune cells modulated progression disease, we randomly assigned 273 individuals with stage T1D to treatment hydroxychloroquine (n = 183; 5 mg/kg per day a maximum 400 mg) or placebo 90) and assessed delayed prevented 2 (i.e., two more islet autoantibodies abnormal glucose tolerance). RESULTS After median follow-up 23.3 months, trial...
Entrustable Professional Activities (EPA) and competencies represent components of a competency-based education framework. EPAs are assessed based on the level supervision (LOS) necessary to perform activity safely effectively. The broad competencies, broken down into narrower subcompetencies, using milestones, observable behaviors one's abilities along developmental spectrum. Integration two methods, accomplished by mapping most relevant subcompetencies each EPA, may provide cross check...
Classical congenital adrenal hyperplasia (CAH) is a potentially life-threatening condition, and crisis major cause of morbidity mortality in affected children. Medical-alert identification (ID) could prevent complications by identifying the need for time-sensitive, critical treatment. Our objectives were to evaluate usage medical-alert IDs CAH youth, ownership awareness amongst their parents, effect an in-clinic educational intervention on ID utilization.Fifty families youth with classical...
Background: The purpose of this study was to collect 1 year real-world data from individuals with type diabetes (T1D) initiating the Medtronic 670G hybrid closed-loop insulin delivery system as part usual care. We sought expand current knowledge understand how use impacts patient-reported outcomes, in addition clinical for children and adults T1D. Methods: Questionnaires were completed by participant (and/or parent) before initiation (baseline) at 6 weeks, months, 12 months enrollment....
Rathke's cleft cysts arise from remnants of pouch and are usually found incidentally on MRI or autopsy. In childhood, the most common presenting symptoms endocrine abnormalities, such as reduced growth hormone secretion, hyperprolactinemia, diabetes insipidus. Non-specific symptoms, headache visual disturbance, may also occur. Although precocious puberty has occasionally been described in association with suprasellar lesions, hamartomas, arachnoid cysts, craniopharyngiomas, to our knowledge...
Despite the significant impact of type 1 diabetes (T1D) on family, few instruments are available to assess health-related quality life (HRQOL) among family members people with T1D. This study aimed develop and evaluate psychometric properties new measures diabetes-specific HRQOL for parents partners We report multistep development validation process self-report Type Diabetes Life (T1DAL) measures, versions youth age <8, 8-11, 12-17, 18-25 years, ≥18 years T1D.First, we conducted qualitative...