A5060102281- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Celiac Disease Research and Management
- Digestive system and related health
- Medical Practices and Rehabilitation
- Adolescent and Pediatric Healthcare
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Medical and Health Sciences Research
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Childhood Cancer Survivors' Quality of Life
- Health and Medical Studies
- Microscopic Colitis
- Regulation of Appetite and Obesity
- Pharmacology and Obesity Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Immunodeficiency and Autoimmune Disorders
- Ovarian function and disorders
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Biomedical and Chemical Research
Medical University of Graz
2016-2025
University of Graz
2010-2023
Universitätsklinik für Kinder und Jugendpsychiatrie
2007-2023
Zentrum für Kinderheilkunde
2008-2021
Graz University Hospital
2014
The possible advantage of hybrid closed-loop therapy (i.e., artificial pancreas) over sensor-augmented pump in very young children with type 1 diabetes is unclear.In this multicenter, randomized, crossover trial, we recruited to 7 years age who were receiving insulin-pump at seven centers across Austria, Germany, Luxembourg, and the United Kingdom. Participants received treatment two 16-week periods, random order, which system was compared (control). primary end point between-treatment...
Celiac disease (CD) has a recognized association with type 1 diabetes. We examined international differences in CD prevalence and clinical characteristics of youth coexisting diabetes versus only.Data sources were as follows: the Prospective Diabetes Follow-up Registry (DPV) (Germany/Austria); T1D Exchange Clinic Network (T1DX) (U.S.); National Paediatric Audit (NPDA) (U.K. [England/Wales]); Australasian Data (ADDN) (Australia). The analysis included 52,721 youths <18 years age clinic visit...
Increased weight gain has been reported prior to disease onset (accelerator hypothesis) and as a side effect of intensified insulin therapy in type 1 diabetes (T1D). Paediatric studies are complicated by the age-dependency gender-dependency BMI, also trend towards obesity general population. The aim this study was evaluate factors related increase BMI during course children adolescents with T1D large multicentre survey.Within DPV database (Diabetespatienten Verlaufsdokumentation)...
Abstract Aim To compare HbA 1c levels across the lifespan in people with type 1 diabetes USA those Germany/Austria, and to examine potential differences between sexes, insulin delivery methods minority status. Methods Data were extracted from US T1D Exchange Registry ( n =18 381 participants 73 sites) German/Austrian Prospective Diabetes Follow‐up Registry, DPV =32 643 362 sites). Mean was calculated for each year of age individuals aged ≤25 years, at 2‐year intervals >25 years. Curves...
OBJECTIVE We aimed to assess the feasibility and safety of hybrid closed-loop insulin delivery in children with type 1 diabetes aged 1–7 years as well evaluate role diluted on glucose control. RESEARCH DESIGN AND METHODS In an open-label, multicenter, multinational, randomized crossover study, 24 pump therapy (median age 5 [interquartile range 3–6] mean ± SD HbA1c 7.4 0.7% [57 8 mmol/mol] total 13.2 4.8 units/day) underwent two 21-day periods unrestricted living we compared (U20) standard...
Objective To evaluate the experiences of families with very young children aged 1 to 7 years (inclusive) type diabetes using day-and-night hybrid closed-loop insulin delivery. Methods Parents/caregivers 20 completed a experience survey following two 3-week periods unrestricted therapy Cambridge FlorenceM system at home. Benefits, limitations, and improvements technology were explored. Results Responders reported reduced burden management, less time spent managing diabetes, improved quality...
Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin variants that yielded antagonistic proteins unrelated children with intense hyperphagia, severe obesity, and high circulating levels of leptin. Both bind to the receptor trigger marginal, if any, signaling. In presence nonvariant leptin, act as competitive antagonists. Thus, treatment recombinant was initiated at doses, which were...
OBJECTIVE To investigate diabetes-specific autoantibodies and additional autoimmune phenomena in a large cohort of young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS Data from 28,671 &lt;30 years diabetes 242 specialized centers Germany Austria were analyzed. RESULTS At least one β-cell antibody was present 81.6% patients. β-cell–Ab-negative significantly younger at onset (P &lt; 0.0001). A total 19.6% had positive thyroid antibodies female predominance (62%, P...
To investigate whether celiac disease (CD) associated with type 1 diabetes increases the risk of microvascular complications.Patients (n = 56,514) aged >10 years duration <20 from 392 centers in Germany and Austria were assigned to one three categories (n): no CD (50,933), biopsy-confirmed (812), or suspected (4,769; clinical diagnosis positive antibodies). The confirmed groups combined analyzed for retinopathy nephropathy. Cox proportional hazards regression was used adjust potential...
OBJECTIVE To quantify age-related variability of insulin needs during day and night closed-loop delivery. RESEARCH DESIGN AND METHODS We retrospectively analyzed data from hybrid studies involving young children (1–6 years old, n = 20), (7–12 years, 21), adolescents (13–17 15), adults (&gt;18 58) with type 1 diabetes. The coefficient variation quantified 3 weeks unrestricted-living use. RESULTS Data 2,365 nights 2,367 days in 114 participants were analyzed. delivery was higher compared...
Background To investigate changes in diabetes treatment over the last two decades three age-groups of children and adolescents with type 1 (T1D) from Germany Austria. Methods 63,967 subjects (<18yr) T1D documented between 1995 2014 DPV-database were included stratified according to age (0.5-<6, 6-<12, 12-<18yr). Regression models applied for insulin regimens (<3 ≥4 injection time points/day, or continuous subcutaneous infusion (CSII)), use rapid- long acting analogues, NPH insulin, frequency...
Objectives To identify differences and similarities in HbA1c levels patterns regarding age gender eight high-income countries. Subjects 66 071 children adolescents below18 years of with type 1 diabetes for at least 3 months one measurement during the study period. Methods Pediatric Diabetes Quality Registry data from Austria, Denmark, England, Germany, Norway, Sweden, United States, Wales were collected between 2013 2014. HbA1c, gender, age, duration used analysis. Results Distribution...
Objective: To evaluate the use of faster acting (FIA) and standard insulin aspart (SIA) with hybrid automated delivery (AID) in active youth type 1 diabetes. Research Design Methods: In this double-blind multinational randomized crossover trial, 30 children adolescents diabetes (16 females; aged 15.0 ± 1.7 years; baseline HbA1c 7.5% 0.9% [58 9.8 mmol/mol]) underwent two unrestricted 4-week periods using AID either FIA or SIA random order. During both interventions, participants were...
OBJECTIVE To compare demographic, clinical, and therapeutic characteristics of children with type 1 diabetes age &lt;6 years across three international registries: Diabetes Prospective Follow-Up Registry (DPV; Europe), T1D Exchange Quality Improvement Network (T1DX-QI; U.S.), Australasian Data (ADDN; Australasia). RESEARCH DESIGN AND METHODS An analysis was conducted comparing 2019–2021 prospective registry data from 8,004 children. RESULTS Mean ± SD ages at diagnosis were 3.2 1.4 (DPV...
Objective: Type 1 diabetes mellitus (T1DM) is associated with other autoimmune diseases such as celiac disease (CD) and Hashimoto thyroiditis. The aim of this study was to evaluate the screening frequency for CD thyroid antibodies in a multicentre survey. Methods: Diabetes Patienten Verlaufsdokumentationssystem (DPV) initiative based on standardized, prospective, documentation children adolescents diabetes. Data from 31 104 patients <18 yr age (52% males, mean 13.1 yr) T1DM 177 paediatric...
Aims To explore parents' experiences of using a hybrid closed-loop system (CamAPS FX) when caring for very young child (aged 1–7 years) with type 1 diabetes. Methods Interviews n = 33 parents 30 children who used the during randomised controlled trial. Data analysis descriptive thematic approach. Results While some were initially reticent about handing control to system, all reported clinical benefits technology, having do less diabetes-related work and needing input over time. Parents...
Abstract Aims The aim of this study was to assess postprandial glycaemic outcomes using automated insulin delivery with faster acting aspart (FIA) or standard (SIA) over 4 weeks in youth (aged 10–18 years) type 1 diabetes. Materials and Methods We undertook a secondary analysis from double‐blind, randomised, crossover comparing FIA SIA an investigational version MiniMed™ 780G. Endpoints included time tight range (70–140 mg/dL; TITR), glucose excursions peak glucose, incremental area under...