A5015780914- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Obesity, Physical Activity, Diet
- Adolescent and Pediatric Healthcare
- Diabetes Management and Education
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gut microbiota and health
- Childhood Cancer Survivors' Quality of Life
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Child and Adolescent Health
- Chronic Disease Management Strategies
- Obesity and Health Practices
- Mobile Health and mHealth Applications
- Lipoproteins and Cardiovascular Health
- Immunodeficiency and Autoimmune Disorders
- Metabolism, Diabetes, and Cancer
- Pharmaceutical studies and practices
- Molecular Biology Techniques and Applications
- Oral microbiology and periodontitis research
- Primary Care and Health Outcomes
Centre Hospitalier de Luxembourg
2016-2025
University of Luxembourg
2015-2025
Universitair Ziekenhuis Brussel
2016-2025
Vrije Universiteit Brussel
2021-2024
Azienda Ospedaliera Universitaria Integrata Verona
2024
European Organisation for Rare Diseases
2023
Medicover
2023
Eli Lilly (United States)
2023
Witten/Herdecke University
2023
KU Leuven
2022
The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral species to intestine considered a rare aberrant event, and hallmark disease. By studying salivary fecal microbial strain populations 310 in 470 individuals from five countries, we found that transmission to, subsequent colonization of, large microbes common extensive among healthy individuals. We evidence for vast majority be transferable, with increased levels colorectal cancer rheumatoid arthritis...
Against a background of near-universally increasing incidence childhood type 1 diabetes, recent reports from some countries suggest slowing in this increase. Occasional also describe cyclical variations incidence, with periodicities between 4 and 6 years.Age/sex-standardised rates for the 0- to 14-year-old age group are reported 26 European centres (representing 22 countries) that have registered newly diagnosed individuals geographically defined regions up 25 years during period 1989-2013....
The gastrointestinal microbiome is a complex ecosystem with functions that shape human health. Studying the relationship between taxonomic alterations and functional repercussions linked to disease remains challenging. Here, we present an integrative approach resolve attributes of microbiota at metagenomic, metatranscriptomic metaproteomic levels. We apply our methods samples from four families multiple cases type 1 diabetes mellitus (T1DM). Analysis intra- inter-individual variation...
OBJECTIVE To find a simple definition of partial remission in type 1 diabetes that reflects both residual β-cell function and efficacy insulin treatment. RESEARCH DESIGN AND METHODS A total 275 patients aged <16 years were followed from onset diabetes. After 1, 6, 12 months, stimulated C-peptide during challenge was used as measure function. RESULTS By multiple regression analysis, negative association between A1C (regression coefficient −0.21, P < 0.001) dose (−0.94, shown....
Abstract The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption mother-to-neonate transmission microbiota through CSD occurs and it affects human physiology. Here we perform metagenomic analysis earliest gut microbial community structures functions. We identify differences in encoded functions between microbiomes vaginally delivered (VD) neonates. Several functional pathways are over-represented VD neonates, including lipopolysaccharide...
Perturbations to the colonization process of human gastrointestinal tract have been suggested result in adverse health effects later life. Although much research has performed on bacterial and succession, less is known about other two domains life, archaea, eukaryotes. Here we describe succession by bacteria, archaea microeukaryotes during first year life (samples collected around days 1, 3, 5, 28, 150, 365) within infants delivered either vaginally or cesarean section using a combination...
Abstract The significant and growing global prevalence of diabetes continues to challenge people with (PwD), healthcare providers, payers. While maintaining near-normal glucose levels has been shown prevent or delay the progression long-term complications diabetes, a proportion PwD are not attaining their glycemic goals. During past 6 years, we have seen tremendous advances in automated insulin delivery (AID) technologies. Numerous randomized controlled trials real-world studies that use AID...
The possible advantage of hybrid closed-loop therapy (i.e., artificial pancreas) over sensor-augmented pump in very young children with type 1 diabetes is unclear.In this multicenter, randomized, crossover trial, we recruited to 7 years age who were receiving insulin-pump at seven centers across Austria, Germany, Luxembourg, and the United Kingdom. Participants received treatment two 16-week periods, random order, which system was compared (control). primary end point between-treatment...
Colorectal cancer (CRC) patients have been shown to possess an altered gut microbiome. Diet is a well-established modulator of the microbiome, and thus, dietary interventions might beneficial effect on CRC. An attenuating ketogenic diet (KD) CRC cell growth has previously observed, however role microbiome in driving this remains unknown. Here, we describe reduced colonic tumor burden upon KD consumption mouse model with humanized Importantly, demonstrate causal relationship through...
Antibodies in sera from newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients are directed to a human islet cell protein of relative molecular mass (Mr) 64,000. Since IDDM seems develop after prodromal period beta-cell autoimmunity, this study has examined whether 64,000 Mr antibodies could be detected 14 individuals who subsequently developed and five first degree relatives have indications altered function. Sera were screened by immunoprecipitation on total detergent lysates...
In a retrospective auxological study of 145 patients seen in Belgium during 9-year period for treatment precocious puberty, 28% appeared to be foreign children (39 girls, one boy) who immigrated 4 5 years earlier from 22 developing countries, without any link particular ethnic or country background. The were either adopted (n = 28) non-adopted 12), the latter having normal weight and height at immigration starting early puberty evidence deprivation. This led hypothesis that mechanism might...
To reevaluate the persistence and stability of previously observed differences between pediatric diabetes centers to investigate influence demography, language communication problems, changes in insulin regimens on metabolic outcome, hypoglycemia, ketoacidosis.This was an observational cross-sectional international study 21 centers, with clinical data obtained from all participants A1C levels assayed one central laboratory. All individuals aged 11-18 years (49.4% female), duration at least 1...
Abstract Aims To assess the importance of family factors in determining metabolic outcomes adolescents with Type 1 diabetes 19 countries. Methods Adolescents aged 11–18 years, from 21 paediatric care centres, countries, and their parents were invited to participate. Questionnaires administered recording demographic data, details insulin regimens, severe hypoglycaemic events number episodes diabetic ketoacidosis. completed parental involvement scale Diabetes Quality Life for Youth—Short Form...