A5070975072- Diabetes Management and Research
- Diabetes and associated disorders
- Cardiovascular and exercise physiology
- Pancreatic function and diabetes
- Muscle metabolism and nutrition
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cardiovascular Effects of Exercise
- Diabetes Management and Education
- Pharmacology and Obesity Treatment
- Dietary Effects on Health
- Diet, Metabolism, and Disease
- Exercise and Physiological Responses
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health and Lifestyle Studies
- Cardiac Imaging and Diagnostics
- Heart rate and cardiovascular health
- Cardiac electrophysiology and arrhythmias
- Alcoholism and Thiamine Deficiency
Friedrich-Alexander-Universität Erlangen-Nürnberg
2024
University of Bayreuth
2020-2023
Medical University of Graz
2019-2022
Division of Chemistry
2021
Research Network (United States)
2020
Swansea University
2017-2019
University of Potsdam
2018-2019
Charité - Universitätsmedizin Berlin
2010
Abstract Aims To investigate the seroconversion following first and second COVID‐19 vaccination in people with type 1 2 diabetes relation to glycaemic control prior analyse response comparison individuals without diabetes. Materials methods This prospective, multicentre cohort study analysed a glycated haemoglobin level ≤58 mmol/mol (7.5%) or >58 (7.5%), respectively, healthy controls. Roche's Elecsys anti‐SARS‐CoV‐2 S immunoassay targeting receptor‐binding domain was used quantify...
The efficacy of flash glucose monitoring (flash GM) systems has been demonstrated by improvements in glycaemia; however, during high rates flux, the performance continuous was impaired, as detailed previous studies. This study aimed to determine GM system daily-life glycaemic challenges such carbohydrate-rich meals, bolus insulin-induced disturbances and acute physical exercise individuals with type 1 diabetes.This comprised four randomized trial visits alternating pre- post-exercise insulin...
Physical exercise is an important component in the management of type 1 diabetes across lifespan. Yet, acute increases risk dysglycaemia, and direction glycaemic excursions depends, to some extent, on intensity duration exercise. Understandably, fear hypoglycaemia one strongest barriers incorporating into daily life. Risk during after can be lowered when insulin-dose adjustments are made and/or additional carbohydrates consumed. Glycaemic has been easier with continuous glucose monitoring...
Background: Recently, high-carbohydrate or low-carbohydrate (HC/LC) diets have gained substantial popularity, speculated to improve physical performance in athletes; however, the effects of short-term changes aforementioned nutritional interventions remain largely unclear. Methods: The present study investigated impact a three-week period HC/low-fat (HC) diet followed by wash-out-phase and subsequent LC on parameters capacity assessed via cardiopulmonary exercise testing, body composition...
Abstract Aims To evaluate the sensor performance of FreeStyle Libre intermittently viewed continuous glucose monitoring system using reference blood levels during moderate‐intensity exercise while on either full or reduced basal insulin dose in people with Type 1 diabetes. Methods Ten participants diabetes [four women, mean ± sd age 31.4 9.0 years, BMI 25.5±3.8 kg/m 2 , HbA 1c 55±7 mmol/mol (7.2±0.6%)] exercised a cycle ergometer for 55 min at moderate intensity 5 consecutive days clinical...
The aim of the study was to assess amount orally administered carbohydrates needed maintain euglycemia during moderate-intensity exercise in individuals with type 1 diabetes. Nine participants diabetes (four women, age 32.1 ± 9.0 years, BMI 25.5 3.9 kg/m2, HbA1c 55 7 mmol/mol (7.2 0.6%)) on insulin Degludec were randomized cycle for min at moderate intensity (63 7% VO2peak) five consecutive days either 75% or 100% their regular basal dose. impact pre-exercise blood glucose concentration...
To compare the time spent in specified glycaemic ranges people with type 1 diabetes (T1D) during 5 consecutive days of moderate-intensity exercise while on either 100% or 75% their usual insulin degludec (IDeg) dose.Nine participants T1D (four women, mean age 32.1 ± 9.0 years, body mass index 25.5 3.8 kg/m2 , glycated haemoglobin 55 7 mmol/mol (7.2% 0.6%) IDeg were enrolled trial. Three before first period, randomized to dose. Participants exercised a cycle ergometer for minutes at moderate...
It is unknown how different types of carbohydrates alter the cardio-autonomic system in healthy individuals. Therefore, aim this study was to investigate heart-rate variability changes single dose ingestion glucose, fructose, glucose and an artificial sweetener (sucralose).In a double-blind randomized crossover placebo-controlled setting, 15 participants received all study-specific substances liquid form. During each 2-h visit, venous blood measured 5-min interval while continuously via...
This study investigated the degree and direction (kHR) of heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing explored relationship with diabetes markers, anthropometry physiological markers in type 1 (T1DM).Sixty-four people T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 1% (62 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by second-degree polynomial representation between post-warm up power output. Adjusted stepwise...
To detail the extent and prevalence of post-exercise nocturnal hypoglycemia following peri-exercise bolus insulin dose adjustments in individuals with type 1 diabetes (T1D) using multiple daily injections insulins aspart (IAsp) degludec (IDeg).Sixteen T1D, completed a single-centred, randomised, four-period crossover trial consisting 23-h inpatient phases. Participants administered either regular (100%) or reduced (50%) (100%; 5.1 ± 2.4, 50%; 2.6 1.2 IU, p < 0.001) individualised IAsp h...
Introduction This prospective observational study sought to establish the glycemic, physiological and dietary demands of strenuous exercise training as part a 9-day performance camp in professional cycling team with type 1 diabetes (T1D). Research design methods Sixteen male cyclists T1D on multiple daily injections (age: 27±4 years; duration T1D: 11±5 body mass index: 22±2 kg/m 2 ; glycated hemoglobin: 7%±1% (50±6 mmol/mol); maximum rate oxygen consumption: 73±4 mL/kg/min) performed road...
To conduct a pooled analysis to assess the performance of intermittently scanned continuous glucose monitoring (isCGM) in association with rate change sensor cohort children, adolescents, and adults type 1 diabetes.
Continuous glucose monitoring (CGM) represents an integral of modern diabetes management, however, there is still a lack sensor performance data when rapidly consuming different liquids and thus changing total body water. 18 healthy adults (ten females, age: 23.1 ± 1.8 years, BMI 22.2 2.1 kg·m−2) performed four trial visits consisting oral ingestion (12 mL per kg mass) either 0.9% sodium chloride, 5% or Ringer’s solution control visit, in which no liquid was administered (control). Sensor...
Abstract Background To explore the impact of glycaemic control (HbA 1c ) on functional capacity during cardio-pulmonary exercise testing in people with type 1 diabetes. Methods Sixty-four individuals diabetes (age: 34 ± 8 years; 13 females, HbA : 7.8 1% (62 mmol/mol), duration diabetes: 17 9 years) performed a cycle ergometer test until volitional exhaustion. Stepwise linear regression was used to relationships between and cardio-respiratory data p ≤ 0.05. Furthermore, participants were...