Sonia Toni
A5057056002- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetic Foot Ulcer Assessment and Management
- Diet and metabolism studies
- Celiac Disease Research and Management
- Diet, Metabolism, and Disease
- Diagnosis and Treatment of Venous Diseases
- Sports injuries and prevention
- Obesity, Physical Activity, Diet
- Health and Lifestyle Studies
- Wound Healing and Treatments
- COVID-19 Clinical Research Studies
- Sports Performance and Training
- Childhood Cancer Survivors' Quality of Life
- Genetics and Neurodevelopmental Disorders
- Skin Diseases and Diabetes
- Liver Disease Diagnosis and Treatment
- Microbial Metabolites in Food Biotechnology
- Blood properties and coagulation
- Digestive system and related health
- Lower Extremity Biomechanics and Pathologies
Azienda Unità Sanitaria Locale Della Romagna
2024
Meyer Children's Hospital
2015-2024
University of Florence
2005-2023
Turku Centre for Computer Science
2023
University of Turku
2023
Åbo Akademi University
2023
Meyer Children's Hospital
2013-2022
Bayer (Germany)
2022
Bridge Of Nucleic Acids Chemistry (Japan)
2021
Meyer (China)
2008-2013
We conducted a retrospective survey in pediatric centers belonging to the Italian Society for Pediatric Diabetology and Endocrinology. The following data were collected all new-onset diabetes patients aged 0–18 years: DKA (pH < 7.30), severe 7.1), preschool children, treatment according ISPAD protocol, type of rehydrating solution used, bicarbonates use, amount insulin infused. Records<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo...
OBJECTIVE To evaluate whether the diagnosis of pediatric type 1 diabetes or its acute complications changed during early phase coronavirus disease 2019 (COVID-19) pandemic in Italy. RESEARCH DESIGN AND METHODS This was a cross-sectional, web-based survey all Italian centers to collect diabetes, diabetic ketoacidosis (DKA), and COVID-19 data patients presenting with new-onset established between 20 February 14 April 2020. RESULTS Fifty-three 68 (77.9%) responded. There 23% reduction new cases...
Permanent neonatal diabetes mellitus (PNDM) is a rare disorder usually presenting within 6 months of birth. Although several genes have been linked to this disorder, in almost half the cases documented Italy, genetic cause remains unknown. Because Akita mouse bearing mutation Ins2 gene exhibits PNDM associated with pancreatic β cell apoptosis, we sequenced human insulin subjects unidentified mutations. We discovered 7 heterozygous mutations 10 unrelated probands. In 8 these patients,...
An etiologic diagnosis of diabetes can affect the therapeutic strategy and prognosis chronic complications. The aim present study was to establish relative percentage different subtypes in patients attending Italian pediatric centers influence an on therapy. This a retrospective study. clinical records 3781 consecutive (age, 0 18 years) referred 15 clinics with or impaired fasting glucose from January 1, 2007 December 31, 2012 were examined. characteristics at their first referral centers,...
To investigate the prevalence of maturity-onset diabetes young (MODY) in Italian children with incidental hyperglycemia.Among 748 subjects age 1-18 years hyperglycemia, minimal diagnostic criteria for MODY were met by 172 families. Mutational analyses glucokinase (GCK) and hepatocyte nuclear factor 1alpha (HNF1A) genes performed.We identified 85 GCK gene mutations 109 probands 10 HNF1A 12 probands. In patients, median neonatal weight at first evaluation lower than those found patients...
A defect in indoleamine 2,3-dioxygenase 1 (IDO1), which is responsible for immunoregulatory tryptophan catabolism, impairs development of immune tolerance to autoantigens NOD mice, a model human autoimmune type diabetes (T1D). Whether IDO1 function also defective T1D still unknown. We investigated sera and peripheral blood mononuclear cells (PBMCs) from children with matched controls. These were further included discovery study identify SNPs that might modify the risk T1D. was characterized...
Background: Glucose sensors consist of real-time continuous glucose monitoring (rtCGM) and intermittently scanned CGM (isCGM). Their clinical use has been widely increasing during the past 5 years. The aim this study is to evaluate percentage time in range (TIR) a large group children with type 1 diabetes (T1D) using nonautomated insulin delivery systems, real-world setting. Methods: An 11-center cross-sectional was conducted January-May 2019. Children T1D <18 years, all rtCGM or isCGM for...
OBJECTIVE To investigate age-period-cohort effects on the temporal trend of type 1 diabetes in children age 0–14 years Italian registries. RESEARCH DESIGN AND METHODS This report is based 5,180 incident cases period 1990–2003 from Registry for Type Diabetes Mellitus Italy (RIDI). Multilevel (random intercept) Poisson regression models were used to model sex, age, calendar time, and birth cohorts trends, taking into account registry-level variance component. RESULTS The incidence rate was...
The aim of this study was to investigate the genetic aetiology permanent diabetes mellitus with onset in first 12 months age.We studied 46 probands permanent, insulin-requiring within 6 life (permanent neonatal [PNDM]/monogenic infancy [MDI]) (group 1) and eight participants diagnosed between 7 age 2). KCNJ11, INS ABCC8 genes were sequentially sequenced all patients. For those who negative initial screening, we examined ERN1, CHGA, CHGB NKX6-1 and, selected probands, CACNA1C, GCK, FOXP3,...
Objective: To document current practices using continuous subcutaneous insulin infusion (CSII) by downloading electronically the 90-d pump data held within memory and relating that to clinical from children adolescents in different pediatric diabetes centers Europe Israel. Methods: Data of patients (1–18 yr) treated with CSII 23 nine European countries Israel were recorded encapture software (PEC International, Frankfurt, Germany). The number who participated was 377 (48% female; mean...
Objective : Children and adolescents with type 1 (insulin-dependent) diabetes mellitus (T1DM) show several impairment of bone metabolism structure, resulting in a higher risk decreased mass its related complications later life. Alterations the nuclear factor-κB ligand (RANKL)/osteoprotegerin (OPG) system have been implicated metabolic diseases characterized by increased osteoclast differentiation activation enhanced resorption. Design We aimed to assess OPG levels investigate possible...
Several studies confirmed the growing rate of Type 1 diabetes mellitus in childhood coinciding with increasing diagnosis viral infections. A study investigating incidence during 1996-1997 showed a higher notification infections Pavia District. The aim was to confirm these results.This evaluated relationship between new cases and those measles, mumps rubella 1996-2001, analysing data newly-diagnosed children, aged 0-14 years enrolled into RIDI (Italian Insulin-dependent Diabetes Registry)...
Objective To identify the role of family's socio-economic and clinical characteristics on metabolic control in children adolescents with type 1 diabetes. Methods In this cross-sectional, multicentre study, 768 subjects diabetes under 18 years age were consecutively recruited from January 2008 to February 2009. Target condition was considered for HbA1c values <7.5% (<58 mmol/mol). A multiple correspondence analysis (MCA) performed analyze association between participants. logistic regression...
Aim/Hypothesis To compare the frequency of diabetic ketoacidosis (DKA) at diagnosis type 1 diabetes in Italy during COVID-19 pandemic 2020 with DKA 2017-2019. Methods Forty-seven pediatric centers caring for &gt;90% young people recruited 4,237 newly diagnosed children between 2017 and a longitudinal study. Four subperiods were defined based on government-imposed containment measures COVID-19, frequencies severe compared same periods Results Overall, increased from 35.7% (95%CI,...
Two vaccines against SARS-CoV-2 are approved by the World Health Organization (WHO) for minors aged 12 years and over. Currently, people with both type 1 diabetes (T1D) 2 (T2D) prioritized vaccination.
To analyze metabolic outcomes, diabetes impact and device satisfaction in children adolescents with type 1 Italy who used different treatment modalities for care a real-life context.
Abstract Backgrounds The incidence of Type 1 Diabetes (T1D) in children and adolescents is increasing by 3–4% per year. Children with T1D (CwD) should receive person-centered, specialized treatment from a multidisciplinary team to ensure appropriate care. Italy the first implement countrywide screening program, which will raise need for funding pediatric study aims update organization Italian Centers diabetes Methods In 2022, members 59 following CwD were invited complete an email survey...
MODY2 is the most prevalent monogenic form of diabetes in Italy with an estimated prevalence about 0.5-1.5%. potentially indistinguishable from other forms diabetes, however, its identification impacts on patients' quality life and healthcare resources. Unfortunately, DNA direct sequencing as diagnostic test not readily accessible expensive. In addition current guidelines, aiming to establish when should be performed, proved a poor detection rate. Aim this study propose reliable easy-to-use...
Abstract This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years age, during 2004–2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe 7.1). Two multiple logistic regression models were used to evaluate time trend considered present versus absent, adjusted for gender, age group geographical area residence diagnosis. Overall, 9,040 cases ascertained....
To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using closed-loop (CLC) system.This was prospective multicentre study Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, their parents participated 3-day multidisciplinary vEC. Clinical data, metrics HbA1c evaluated over 12 weeks prior Control-IQ update after vEC.Forty-three (aged 7-16 years) families The median percentage time target range (70-180...