A5027329923- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Sexual Differentiation and Disorders
- Celiac Disease Research and Management
- Thyroid Disorders and Treatments
- Microbial Metabolites in Food Biotechnology
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Helicobacter pylori-related gastroenterology studies
- Skin Diseases and Diabetes
- Birth, Development, and Health
- Childhood Cancer Survivors' Quality of Life
- Retinal Diseases and Treatments
- Galectins and Cancer Biology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Genetic Syndromes and Imprinting
- Digestive system and related health
- Testicular diseases and treatments
- Folate and B Vitamins Research
- Adolescent and Pediatric Healthcare
- Diabetes Treatment and Management
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
University of Bologna
2006-2021
Policlinico S.Orsola-Malpighi
1987-2017
European School of Oncology
2008
Ospedale Regina Margherita
2006
Ospedale Microcitemico
2006
Ospedale di Bolzano
2006
Bayreuth Medical Center
1998
Takeda (Germany)
1998
Age-related changes in uterine and ovarian morphology size were studied 114 normal premenarcheal girls using a real-time mechanical sector scanner. Reference growth values obtained for total length, anteroposterior diameters of the corpus cervix, corpus/cervix ratio, volumes. Up to 7 years age was not influenced by there relative predominance cervix over corpus. Thereafter uterus underwent regular increase gradually became larger than cervix. Ovarian volume relatively stable up 5 years, when...
Permanent neonatal diabetes mellitus (PNDM) is a rare disorder usually presenting within 6 months of birth. Although several genes have been linked to this disorder, in almost half the cases documented Italy, genetic cause remains unknown. Because Akita mouse bearing mutation Ins2 gene exhibits PNDM associated with pancreatic β cell apoptosis, we sequenced human insulin subjects unidentified mutations. We discovered 7 heterozygous mutations 10 unrelated probands. In 8 these patients,...
Real time ultrasonography of the pelvic organs was performed on 114 normal premenarcheal girls aged between 2 years and 13 11 months. Values were obtained for total uterine length, anteroposterior diameters corpus cervix, corpus/cervix ratio, ovarian volumes resultant data grouped according to age. It concluded that there is no change in size until approximately 7 Then uterus begins enlarge, both prepubertal girls, whom this an age related function, pubertal whose growth influenced not only...
To evaluate self and parent reports on quality of life (QoL) psychological adjustment youths with type 1 diabetes, in comparison to a general paediatric population, identify relationships between disease duration, metabolic control parameters.Participants included 70 diabetes their parents. They were compared non-diabetic subjects. Data analyzed the whole group subgroups aged 6-10, 11-13 14-18 yr. All cases performed pediatric QoL, Child Behaviour Checklist, filled by parents, Youth...
ABSTRACT Between 1987 and 2004, 331 consecutive children, all newly diagnosed with type 1 diabetes mellitus in our pediatric clinic, underwent repeated serological screening for celiac disease (CD) by means of anti‐endomysial antibodies, measured prospectively between 1994 retrospectively, using frozen banked serum, 1993. There were 22 cases (6.6%) biopsy‐proven CD among the diabetic children. The prevalence was significantly ( P = 0.015) higher after (10.6%) than before (3.3%). rapid change...
There is currently a debate about the use of pharmacological and physiological tests to define GH deficiency predict response therapy. In addition, good therapy has also been described in subjects without deficiency. For further information, we reevaluated secretion during replacement group children defined as deficient examined subdivided according secretion. One hundred eighty four (113 boys 71 girls) initially diagnosed with by means (peak < 8 micrograms/L after arginine L-dopa tests)...
The purpose of this study was to determine whether the continuous glucose monitoring system (CGMS) (MiniMed, Sylmar, CA) 1) is sufficiently representative overall metabolic control as assessed by HbA(1c), 2) could be used identify a particular blood threshold value affecting hemoglobin glycation; and 3) able show any relationship between glycemic profiles HbA(1c) levels.Of 44 pediatric patients with type 1 diabetes who wore CGMS devices, 28 subjects were selected for study. Criteria...
Growth of 79 children with diabetes was analysed at diagnosis and again after one to 10.7 years treatment insulin. Both sexes were tall onset, whereas the last observation boys alone showed significant growth retardation. Height standard deviation score (SDS), however, no fall either in 32 subjects reassessed five disease or 18 examined full stature. Skeletal maturity not significantly impaired treatment. Pubertal spurt reduced, especially girls onset around puberty. We found correlation...
Capillary blood samples from 42930 infants born in the Italian region of Emilia-Romagna were collected for 17-hydroxyprogesterone radioimmunoassays on days 2, 3, 4, 5, 6, and 7, or between 7 15 life. A microfilter paper method modified that Pang et al.1 was used this assay. Pathologic values found 5 giving an incidence homogeneous Caucasian population 1:8586. We also investigated relation to day sampling possible correlation birthweight gestational age. concluded neonatal screening...
We used the radioimmunoassay (RIA) method to determine somatomedin-C (SmC) basal values in 59 diabetic children and adolescents (20 prepubertal 39 pubertal subjects; age range 2.75–20.16 yr; duration of diabetes 0.08–15.83 yr) 274 control subjects. In comparing subjects with controls, we considered only those 50 who were matched i.e., not over 16 yr chronological age. SmC levels patients no different from age-matched children, whereas was significantly lower than respective (P &lt;...
To evaluate the frequency of normalization, persistence remission, and impact on normalization glycemic control lipid profile, we analyzed data from a retrospective observational cohort study type 1 diabetic children adolescents with abnormal urinary albumin excretion (UAE).All (n = 41) who had persistent UAE in period 1984 to 2008 followed up until 2009 (follow-up duration 13.1 ± 6.2 years) were included study. Nine patients progressed macroalbuminuria; 24 administered ACE inhibitor...
To compare the effect of prepubertal duration diabetes on occurrence complications in two groups patients after same number years disease.This multicenter study enrolled 105 aged 16-40.3 years; 53 were at diagnosis (aged 0-3) and 52 pubertal (Tanner stage) 9-14.9. The mean disease was 19.8 19.5 for patients, respectively. In all retinal photographs taken centrally graded. Urinary albumin excretion (UAE; 86 case subjects), blood pressure (BP; 89 lifetime HbA(1c) (72 subjects) also...
Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group disorders characterized by early onset non-insulin-dependent mellitus, autosomal dominant inheritance, and primary defect in function beta cells pancreas. Mutations glucokinase (GCK) gene account for 8%–56% MODY, with highest prevalences being found southern Europe. While screening GCK mutations 28 MODY families Italian origin, we identified 17 different (corresponding to 61% prevalence), including eight...
ABSTRACT. Urinary albumin excretion (UAE) was determined by radioimmunoassay in two 24 h urine collections from 125 diabetic children and adolescents 71 normal matched for age sex. Thirteen patients (10.4%) aged > 12 years had microalbuminuria, i. e. log transformed UAE levels above the upper range (24.5 mg/24 h). values were positively correlated with age, GH secretion, but not duration of disease, glycosylated hemoglobin, renal size or N‐acetyl‐beta‐glucosaminidase excretion. Diabetic...
The behavior of the secretion ACTH, GH, and plasma cortisol during insulin-induced hypoglycemia test on normal obese children was studied. above-mentioned hormones determined by calculating integrals curves. mean values ACTH curves do not show any significant differences between two groups children. ratios cortisoland a difference (P < 0.01). Since are practically same in both groups, refers to lower found This enables us make hypothesis that child function pituitary-adrenal axis, at least...
The aim of the present study was to evaluate retrospectively influence various auxological and laboratory parameters on final height in a group GH-deficient children after replacement therapy compare their with that short normal GH secretion hence not treated. evaluated 83 patients (51 males 32 females) affected by idiopathic isolated deficiency treated recombinant human (hGH) for 2-7 years. Inclusion criteria at start treatment were stature (mean chronological age standard deviation score...
In 22 normal boys, 33 unilateral and 14 bilateral cryptorchids, a gonadal function test (2000 IU of HCG im each day for three days assays plasma testosterone oestradiol-17beta before after the administration) as well an LH-RH were carried out. 60% cases, both cryptorchid (both in basal conditions stimulus) found to be less than sensitivity (5 pg/ml) method, While was similar under groups children, it significantly lower mean value control group only cryptorchids. The levels, stimulus, are...