A5066265594- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Diabetes Treatment and Management
- Childhood Cancer Survivors' Quality of Life
- Pituitary Gland Disorders and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Adolescent and Pediatric Healthcare
- Health and Lifestyle Studies
- Hypothalamic control of reproductive hormones
- Genetic Syndromes and Imprinting
- Obesity, Physical Activity, Diet
- Celiac Disease Research and Management
- Birth, Development, and Health
- Pharmaceutical studies and practices
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Thyroid Disorders and Treatments
- Myasthenia Gravis and Thymoma
Istituto delle Scienze Neurologiche di Bologna
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025
Azienda USL di Bologna
2021-2024
Policlinico S.Orsola-Malpighi
2015-2024
Azienda Unità Sanitaria Locale Della Romagna
2024
Arcispedale Sant'Anna
2024
University of Ferrara
2024
University of Bologna
2013-2022
Virtual High School
2022
University of Milan
2017
We conducted a retrospective survey in pediatric centers belonging to the Italian Society for Pediatric Diabetology and Endocrinology. The following data were collected all new-onset diabetes patients aged 0–18 years: DKA (pH < 7.30), severe 7.1), preschool children, treatment according ISPAD protocol, type of rehydrating solution used, bicarbonates use, amount insulin infused. Records<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo...
The COVID-19 pandemic forced the Italian government to issue extremely restrictive measures on daily activities since 11 March 2020 ('lockdown'), which may have influenced metabolic control of type 1 diabetes mellitus (T1D). aims study were investigate continuous glucose monitoring (CGM) metrics in children and adults with T1D during lockdown identify their potentially related factors.We enrolled 130 consecutive patients (30 (≤12 years), 24 teenagers (13-17 76 (≥18 years)) using either...
Glycemia risk index (GRI) is a novel composite metric for the evaluation of safety glycemic management and control. The aim this study was to evaluate GRI its correlations with continuous glucose monitoring (CGM) metrics by analyzing real-life CGM data in 1067 children/adolescents type 1 diabetes (T1D) using four different treatment strategies (intermittently scanned [isCGM]-multiple daily injections [MDIs]; real-time CGM-MDIs; rtCGM-insulin pump; hybrid closed-loop [HCL] therapy)....
OBJECTIVE To investigate glucose metrics and identify potential predictors of the achievement glycemic outcomes in children adolescents during their first 12 months MiniMed 780G use. RESEARCH DESIGN AND METHODS This multicenter, longitudinal, real-world study recruited 368 with type 1 diabetes (T1D) starting SmartGuard technology between June 2020 2022. Ambulatory profile data were collected a 15-day run-in period (baseline), 2 weeks after automatic mode activation, every 3 months. The...
Forty-nine children with short stature (age range, 4.1-15.9 yr) were examined. Twenty-four (group 1) submitted twice to an arginine and a sleep test (12-h overnight GH profile). Twenty-five patients 2) L-dopa test. Coefficients of variation calculated between both the results pharmacological (peak area under curve) tests [mean concentration (MGHC), peak, curve, number peaks above 5 micrograms/L, peak area]. In group 1 coefficient parameters was significantly lower than that (P less 0.01...
Evaluation of the sellar area was performed with magnetic resonance imaging in 101 patients (age range 0.8-27 years) hypopituitarism, isolated diabetes insipidus, hypogonadotrophic hypogonadism, and central precocious puberty. The hypopituitary (n = 70) included multiple pituitary deficiency 23), insipidus 5), growth hormone 42). showed pathological morphological findings all cases, stalk posterior lobe always involved. group associated had abnormal four five cases not visible cases. Only 42...
To evaluate self and parent reports on quality of life (QoL) psychological adjustment youths with type 1 diabetes, in comparison to a general paediatric population, identify relationships between disease duration, metabolic control parameters.Participants included 70 diabetes their parents. They were compared non-diabetic subjects. Data analyzed the whole group subgroups aged 6-10, 11-13 14-18 yr. All cases performed pediatric QoL, Child Behaviour Checklist, filled by parents, Youth...
ABSTRACT Between 1987 and 2004, 331 consecutive children, all newly diagnosed with type 1 diabetes mellitus in our pediatric clinic, underwent repeated serological screening for celiac disease (CD) by means of anti‐endomysial antibodies, measured prospectively between 1994 retrospectively, using frozen banked serum, 1993. There were 22 cases (6.6%) biopsy‐proven CD among the diabetic children. The prevalence was significantly ( P = 0.015) higher after (10.6%) than before (3.3%). rapid change...
Background: Glucose sensors consist of real-time continuous glucose monitoring (rtCGM) and intermittently scanned CGM (isCGM). Their clinical use has been widely increasing during the past 5 years. The aim this study is to evaluate percentage time in range (TIR) a large group children with type 1 diabetes (T1D) using nonautomated insulin delivery systems, real-world setting. Methods: An 11-center cross-sectional was conducted January-May 2019. Children T1D <18 years, all rtCGM or isCGM for...
Possible causes of error in the diagnosis isolated GH deficiency are variability response to repeated tests, existence transient deficiencies, and low levels found short statured children with delayed puberty. Sixty-three patients variously expressed were retested (1 sleep test 2 pharmacological tests) after 1-3.9 yr therapy (dose, 15 U/m2.week). Forty-eight subjects had arginine, L-dopa, tests (mean serum concentration) twice, while only arginine L-dopa tests. All 1 month withdrawal from...
Obesity-related insulin resistance is associated with fatty liver, dyslipidemia, and low plasma adiponectin. Insulin due to receptor (INSR) dysfunction none of these, but when the downstream kinase AKT2 phenocopies obesity-related resistance. We report 5 patients SHORT syndrome C-terminal mutations in PIK3R1, encoding p85α/p55α/p50α subunits PI3K, which act between INSR AKT signaling. Four had extreme without dyslipidemia or hepatic steatosis. In 3 these 4, adiponectin was preserved, as...
The diagnosis of GH deficiency (GHD) in children and adolescents is established when concentrations fail to reach an arbitrary cut-off level after at least two provocative tests. objective the study was define optimal cut-offs tests adolescents.Retrospective 372 subjects who underwent evaluation secretion. IGF-I were measured by chemiluminescence assay all samples. Receiver operating characteristic (ROC) analysis used evaluate diagnostic accuracy tests.Seventy four patients with organic GHD...
In the last decade Sanger method of DNA sequencing has been replaced by next-generation (NGS). NGS is valuable in conditions characterized high genetic heterogeneity such as neonatal diabetes mellitus (NDM).
There is currently a debate about the use of pharmacological and physiological tests to define GH deficiency predict response therapy. In addition, good therapy has also been described in subjects without deficiency. For further information, we reevaluated secretion during replacement group children defined as deficient examined subdivided according secretion. One hundred eighty four (113 boys 71 girls) initially diagnosed with by means (peak < 8 micrograms/L after arginine L-dopa tests)...
The purpose of this study was to determine whether the continuous glucose monitoring system (CGMS) (MiniMed, Sylmar, CA) 1) is sufficiently representative overall metabolic control as assessed by HbA(1c), 2) could be used identify a particular blood threshold value affecting hemoglobin glycation; and 3) able show any relationship between glycemic profiles HbA(1c) levels.Of 44 pediatric patients with type 1 diabetes who wore CGMS devices, 28 subjects were selected for study. Criteria...
Several computed tomographic scan studies have described empty sellae in children with hypothalamic-pituitary disorders. Magnetic resonance imaging, however, is a more precise technique for visualizing the intrasellar content, such as stalk and pituitary lobes. Using magnetic we studied 339 adolescents (mean age +/- SD, 12.7 4.5 yr) possible disorders to ascertain frequency of primary sella examine its relationships other abnormalities, function, adverse perinatal events. One hundred...
Objective After a previous survey on the incidence of diabetic ketoacidosis (DKA) at onset type 1 diabetes in children 2013–2014 Italy, we aimed to verify possible decline DKA during national prevention campaign. Design Prospective observational study. Setting Multicentre study throughout Italy. Intervention National awareness campaign started November 2015 and held until December 2017. Patients During 2016 2017 collected data all patients aged 0–18 years with new-onset diabetes. Main...
Aim/Hypothesis To compare the frequency of diabetic ketoacidosis (DKA) at diagnosis type 1 diabetes in Italy during COVID-19 pandemic 2020 with DKA 2017-2019. Methods Forty-seven pediatric centers caring for &gt;90% young people recruited 4,237 newly diagnosed children between 2017 and a longitudinal study. Four subperiods were defined based on government-imposed containment measures COVID-19, frequencies severe compared same periods Results Overall, increased from 35.7% (95%CI,...
Abstract Backgrounds The incidence of Type 1 Diabetes (T1D) in children and adolescents is increasing by 3–4% per year. Children with T1D (CwD) should receive person-centered, specialized treatment from a multidisciplinary team to ensure appropriate care. Italy the first implement countrywide screening program, which will raise need for funding pediatric study aims update organization Italian Centers diabetes Methods In 2022, members 59 following CwD were invited complete an email survey...
Context: Poor sensitivity of IGF binding protein (IGFBP)-3 assessment in the work-up GH deficiency (GHD) has been ascribed to equal affinity IGFBP-3 for IGF-I and IGF-II proteolysis. Objective: The objective this study was determine dependency proteolysis patients with GHD from childhood young adulthood. Design: This cross-sectional. Setting: a national multicenter performed university hospitals. Patients: One hundred thirty-one subjects (chronological age, 1.3–25 yr), 72 59 idiopathic short...