A5026838445- Bariatric Surgery and Outcomes
- Pancreatic function and diabetes
- Diet and metabolism studies
- Diabetes Management and Research
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Gestational Diabetes Research and Management
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Diabetes Management and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Maternal Mental Health During Pregnancy and Postpartum
- Mobile Health and mHealth Applications
- Body Contouring and Surgery
- Pancreatitis Pathology and Treatment
- Obesity and Health Practices
- Epigenetics and DNA Methylation
- Breastfeeding Practices and Influences
- Retinal Diseases and Treatments
- Genetic Syndromes and Imprinting
University of Auckland
2016-2025
Counties Manukau District Health Board
2019-2025
Greenlane Clinical Centre
2018-2025
Maurice Wilkins Centre
2015-2024
Auckland District Health Board
2016-2024
Middlemore Hospital
2019-2023
Auckland City Hospital
2011-2020
Christ University
2019
Mathematical Sciences Publishers (United States)
2016
University of Warwick
2016
BackgroundProbiotics may help to prevent symptoms of anxiety and depression through several putative mechanisms.ObjectiveThe aim this study was evaluate the effect Lactobacillus rhamnosus HN001 (HN001) given in pregnancy postpartum on maternal period. This a secondary outcome, primary outcome being eczema offspring at 12 months age.Design, Setting, ParticipantsA randomised, double-blind, placebo-controlled trial postnatal mood conducted 423 women Auckland Wellington, New Zealand. Women were...
Abstract Dysbiotic gut microbiota have been implicated in human disease. Diet-based therapeutic strategies used to manipulate the towards a more favourable profile. However, it has demonstrated that large inter-individual variability exists response dietary intervention. The primary objective of this study was investigate whether habitually low fibre (LDF) v . high (HDF) intakes influence an inulin-type fructan prebiotic. In randomised, double-blind, placebo-controlled, cross-over study,...
Human adipose depots are functionally distinct. Yet, recent single-nucleus RNA sequencing (snRNA-seq) analyses largely uncovered overlapping or similar cell-type landscapes. We hypothesized that adipocyte subtypes, differentiation trajectories and/or intercellular communication patterns could illuminate this depot similarity–difference gap. For this, we performed snRNA-seq of human subcutaneous visceral tissues (five ten samples, respectively). Of 27,665 nuclei in both depots, most were...
Objective To investigate whether reported fast-food consumption over the previous year is associated with higher childhood or adolescent body mass index (BMI). Design Secondary analysis from a multicentre, multicountry cross-sectional study (International Study of Asthma and Allergies in Children (ISAAC) Phase Three). Subjects methods Parents/guardians children aged 6–7 completed questionnaires which included questions about their children's asthma allergies, consumption, height weight....
There may be a link between disruption to the gut microbiota in early life and later neurocognitive outcomes. We hypothesised that antibiotic use is associated with detrimental effect on outcomes.Eight hundred seventy-one European mothers their children enrolled Auckland Birthweight Collaborative Study at birth. Information during first year of 12 months three-and-a-half years age was gathered via maternal interview. Intelligence test scores measures behavioural difficulties were obtained...
The study aims to assess whether supplementation with the probiotic Lactobacillus rhamnosus HN001 (HN001) can reduce prevalence of gestational diabetes mellitus (GDM). A double-blind, randomised, placebo-controlled parallel trial was conducted in New Zealand (NZ) (Wellington and Auckland). Pregnant women a personal or partner history atopic disease were randomised at 14-16 weeks' gestation receive (6×109 colony-forming units) (n 212) placebo 211) daily. GDM 24-30 weeks assessed using...
<h3>Abstract</h3> <h3>Objective</h3> To determine the effectiveness of a theoretically based and individually tailored, text message based, diabetes self management support intervention (SMS4BG) in adults with poorly controlled diabetes. <h3>Design</h3> Nine month, two arm, parallel randomised trial. <h3>Setting</h3> Primary secondary healthcare services New Zealand. <h3>Participants</h3> 366 participants aged 16 years over type 1 or 2 (HbA1c ≥65 mmol/mol 8%) between June 2015 November 2016...
Aims HaemoglobinA1c (HbA1c) is recommended for diabetes diagnosis but fasting plasma glucose (FPG) has been useful identifying patients with glucokinase (GCK) mutations which cause lifelong persistent hyperglycaemia. We aimed to derive age-related HbA1c reference ranges these determine how well can discriminate a GCK mutation from unaffected family members and young-onset type 1 (T1D) 2 (T2D) investigate the proportion of carriers diagnosed using and/or FPG diagnostic criteria. Methods...
Background Studies exploring the effect of television viewing on obesity throughout childhood are conflicting. Most studies have been confined to single high-income countries. Our aim was examine association between habits and Body Mass Index (BMI) in adolescents children a multicentre worldwide sample. Methods In International Study Asthma Allergies Children Phase Three, aged 12 15 years completed questionnaires which included questions habits, height weight. Parents/guardians 5 8 same...
OBJECTIVE To determine whether silastic ring laparoscopic Roux-en-Y gastric bypass (SR-LRYGB) or sleeve gastrectomy (LSG) produces superior diabetes remission at 5 years. RESEARCH DESIGN AND METHODS In a single-center, double-blind trial, 114 adults with type 2 and BMI 35–65 kg/m2 were randomly assigned to SR-LRYGB LSG (1:1; stratified by age-group, group, ethnicity, duration, insulin therapy) using web-based service. Diabetes other metabolic medications adjusted according prespecified...
The increasing prevalence of diabetes and costly long-term complications associated with poor glycemic control are issues facing health services worldwide. Diabetes self-management, the support care providers, is critical for successful outcomes, however, frequent clinical contact costly. Text messages via short message service (SMS) have advantage instant transmission at low cost and, given ubiquity mobile phones, may be ideal platform delivery self-management support. A tailored text...
Abstract Background In a two‐centre randomized placebo‐controlled trial of Lactobacillus rhamnosus HN001 (HN001) (6 × 10 9 colony‐forming units [cfu]) or Bifidobacterium lactis HN019 (HN019) (9 cfu) taken daily from 35‐week gestation to 6 months’ post‐partum in mothers while breastfeeding and birth age 2 years infants, we showed that significantly protected against eczema development at 2, 4 atopic sensitization years. There was no effect HN019. We report here the findings for 11 year...
Diets which emphasize intakes of plant-based foods are recommended to reduce disease risk and for promoting healthy weight. The aim this study was examine the association between fruit, vegetables, pulses nut intake body mass index (BMI) across countries in adolescents (13-14 years) children (6-7 years). Data from International Study Asthma Allergies Childhood; 77,243 children's parents 201,871 used dietary (Food Frequency Questionnaire) BMI using general linear models, adjusting country...