A5066580231- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Cannabis and Cannabinoid Research
- Venous Thromboembolism Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obesity, Physical Activity, Diet
- Diagnosis and Treatment of Venous Diseases
- Respiratory Support and Mechanisms
- IL-33, ST2, and ILC Pathways
- Central Venous Catheters and Hemodialysis
- Bee Products Chemical Analysis
- Neonatal Respiratory Health Research
- Child Nutrition and Water Access
- Birth, Development, and Health
- Social Media in Health Education
- COVID-19 and Mental Health
- Gut microbiota and health
- Ethics in Clinical Research
- Cardiac Arrest and Resuscitation
- Respiratory viral infections research
- Religion, Spirituality, and Psychology
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
Medical Research Institute of New Zealand
2015-2025
Capital and Coast District Health Board
2013-2022
Victoria University of Wellington
2013-2022
University of Otago
2021
University of Oxford
2021
Imperial College London
2021
In double-blind, placebo-controlled trials, budesonide–formoterol used on an as-needed basis resulted in a lower risk of severe exacerbation asthma than use short-acting β2-agonist (SABA); the was similar to that budesonide maintenance therapy plus SABA. The availability data from clinical trials designed better reflect practice would be beneficial.
Whether conservative management is an acceptable alternative to interventional for uncomplicated, moderate-to-large primary spontaneous pneumothorax unknown.In this open-label, multicenter, noninferiority trial, we recruited patients 14 50 years of age with a first-known, unilateral, pneumothorax. Patients were randomly assigned immediate the (intervention group) or observational approach (conservative-management and followed 12 months. The outcome was lung reexpansion within 8 weeks.A total...
Objective To investigate whether reported fast-food consumption over the previous year is associated with higher childhood or adolescent body mass index (BMI). Design Secondary analysis from a multicentre, multicountry cross-sectional study (International Study of Asthma and Allergies in Children (ISAAC) Phase Three). Subjects methods Parents/guardians children aged 6–7 completed questionnaires which included questions about their children's asthma allergies, consumption, height weight....
Background Studies exploring the effect of television viewing on obesity throughout childhood are conflicting. Most studies have been confined to single high-income countries. Our aim was examine association between habits and Body Mass Index (BMI) in adolescents children a multicentre worldwide sample. Methods In International Study Asthma Allergies Children Phase Three, aged 12 15 years completed questionnaires which included questions habits, height weight. Parents/guardians 5 8 same...
ABSTRACT Background and objective Increased arterial carbon dioxide tension ( PaCO 2 ) is an important complication of acute exacerbations COPD . The effects nasal high‐flow cannulae NHF on in patients with exacerbations, whether this therapy should be used clinical situation, are less certain. We aimed to investigate the effect admitted hospital a exacerbation. Methods performed single‐centre randomized controlled cross‐over trial 24 inpatients receiving oxygen via standard prongs SNPs )....
Diets which emphasize intakes of plant-based foods are recommended to reduce disease risk and for promoting healthy weight. The aim this study was examine the association between fruit, vegetables, pulses nut intake body mass index (BMI) across countries in adolescents (13-14 years) children (6-7 years). Data from International Study Asthma Allergies Childhood; 77,243 children's parents 201,871 used dietary (Food Frequency Questionnaire) BMI using general linear models, adjusting country...
There has been considerable international variation in mortality during the COVID-19 pandemic. The objective of this study was to investigate differences between registered as due and excess all-cause reported countries worldwide pandemic.Ecological analysis 22 compared 5-year historical mortality, expected (calculated plus deaths attributed COVID-19). Data available from first week January 2020 that most recently were analysed.Compared preceding 5 years, there an 716 616 deaths, which 64.3%...
Serum periostin is a potential biomarker of response to therapies that target type 2 inflammation in asthma. The objectives this study were describe: 1) the distribution serum levels adults with symptomatic airflow obstruction; 2) its relationship other variables, including biomarkers; and 3) effect inhaled corticosteroids on levels. measured cross-sectional exploring phenotypes biomarkers 386 patients aged 18–75 years who reported wheeze breathlessness past 12 months. In 49 ICS-naïve...
Objective To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis. Design Prospective parallel randomised controlled open-label superiority trial. Setting 76 community pharmacies across between 10 September 2015 and 13 December 2017. Participants 952 adults within first 72 hours a labialis episode. Interventions Random assignment 1:1 to either 5% cream or (90%)/glycerine (10%) cream, both applied five times daily. Outcome measures...
BackgroundThe Janus kinase (JAK) pathway mediates the activity of many asthma-relevant cytokines, including IL-4 and IL-13. GDC-0214 is a potent, inhaled, small-molecule JAK inhibitor being developed for treatment asthma.ObjectiveWe sought to determine whether reduces fractional exhaled nitric oxide (Feno), JAK1-dependent biomarker airway inflammation, in patients with mild asthma.MethodsWe conducted double-blind, randomized, placebo-controlled, phase 1 proof-of-activity study adults asthma...
The clinical utility of serum periostin as a type 2 biomarker in asthma is limited by lack reference range values derived from population without respiratory disease.To derive age- and sex-related intervals for an adult or COPD.Serum levels were measured 480 individuals, comprising 60 female male adults each the 18- to 30-year, 31- 45-year, 46- 60-year 61- 75-year age groups. Key exclusion criteria included doctor's diagnosis asthma, chronic bronchitis COPD, history wheezing use inhalers...
Background: Respiratory viruses such as influenza and human rhinoviruses are temperature sensitive. Rhinothermy delivers heated, humidified air to the upper airways via nares, by possibly inhibiting viral replication, it is proposed a potential therapy attenuate severity duration of common cold or symptoms. The effect rhinothermy on nasopharyngeal space uncertain. objective this study was investigate delivering 100% at 41°C temperature. hypothesis that mean while nose breathing would be...
Patterns of inhaled β2-agonist therapy use during severe asthma exacerbations before hospital attendance are poorly understood.To assess prior to attendance.We undertook an exploratory post hoc analysis data from a 6-month clinical trial 303 patients randomised combination budesonide/formoterol inhaler according Single as Maintenance And Reliever Therapy regimen ('SMART') or fixed-dose with salbutamol reliever ('Standard'). for 14 days exacerbation were determined by electronic monitoring...