A5102738983- Biofuel production and bioconversion
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Chronic Kidney Disease and Diabetes
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Anaerobic Digestion and Biogas Production
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Microbial Metabolic Engineering and Bioproduction
- Dialysis and Renal Disease Management
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Erythrocyte Function and Pathophysiology
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Blood groups and transfusion
- Cervical Cancer and HPV Research
- Peptidase Inhibition and Analysis
- Renal Diseases and Glomerulopathies
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Blood disorders and treatments
- Economic and Financial Impacts of Cancer
Huazhong University of Science and Technology
2012-2024
Tongji Hospital
2013-2024
Shandong University of Technology
2023-2024
Guangzhou Medical University
2015-2024
Hangzhou Normal University
2024
Hebei Medical University
2019-2023
Second Hospital of Hebei Medical University
2019-2023
First Affiliated Hospital of Nanchang University
2022
Nanchang University
2022
Guangxi Medical University
2015-2020
Systemic immune-inflammation index (SII), based on lymphocyte (L), neutrophil (N), and platelet (P) counts, was recently developed reflects comprehensively the balance of host inflammatory immune status. We explored its prognostic value in localized gastric cancer (GC) after R0 resection potential associations with Thymidine phosphorylase (TYMP), which reported to increase migration invasion cells. A total 455 GC patients who received D2 gastrectomy were enrolled. Blood samples obtained...
Colon cancer (CC) is one of the most frequent malignancies in world, with a high rate morbidity and death. In CC, necroptosis long noncoding RNA (lncRNAs) are crucial, but mechanism not completely clear. The goal this study was to create new signature that might predict patient survival tumor immunity patients CC. Expression profiles necroptosis-related lncRNAs 473 CC were retrieved from TCGA database. A consensus clustering analysis based on differentially expressed (DE) genes prognostic...
Abstract Reperfusion therapy after acute myocardial infarction (AMI) can effectively restore the blood supply and nutritional support of ischemic myocardium save dying myocardium. However, ischaemia‐reperfusion (I/R) injury has become a new threat to reperfusion for AMI. Many long‐chain noncoding RNAs (lncRNAs) are dysregulated by I/R damage. Of these lncRNAs, Gpr19 was selected as potential gene interest based on its high expression change. We aimed explore functional role molecular...
More than 2 billion women are experiencing the menopausal transition in China, and some of these have hypertension. Limited studies has focused on perimenopausal syndrome hypertension a specific population, so we aimed to investigate prevalence analyse their relationships risk factors South China.
Abstract Background Studies evaluating the effectiveness of immune checkpoint inhibitors (ICI) for endometrial cancer (EC) are limited. This study aimed to assess efficacy PD-1/PD-L1 as monotherapy EC by conducting a meta-analysis. The predictive significance MMR status, biomarker ICI response, also required further investigation. Methods A systematic literature search was conducted in English databases until September 2023. analysis included objective response rate (ORR), disease control...
Circular RNAs (circRNAs) have been identified as vital regulators in cardiovascular diseases, including acute myocardial infarction (AMI). In this study, the function and mechanism of circRNA heparan sulfate proteoglycan 2 (circHSPG2) hypoxia-induced injury AC16 cardiomyocytes were investigated. cells stimulated with hypoxia to establish an AMI cell model vitro. Real-time quantitative PCR western blot assays performed quantify expression levels circHSPG2, microRNA-1184 (miR-1184),...
There is currently no consensus on the relationship between human papillomavirus (HPV) infection and pathogenic process of esophageal squamous cell carcinoma (ESCC). Therefore, a retrospective study was performed to explore association HPV ESCC, where 225 patients with diagnosed ESCC 224 matched controls were enrolled in stratified according smoking alcohol consumption. Enzyme‐linked immunosorbent assay used determine seropositivity by detection either IgG or IgM anti‐HPV antibodies. In...
Abstract Ischemia/reperfusion (I/R)‐mediated acute myocardial infarction (AMI) is a major pathological factor implicated in the progression of ischemic heart disease (IHD). Long non‐coding RNA plays an important role regulating occurrence and development cardiovascular disease. The aim this study was to investigate LINC00261 hypoxia/reoxygenation (H/R)‐induced cardiomyocyte apoptosis. relative expression LINC00261, miR‐23b‐3p NRF2 were determined rats I/R tissues H/R‐induced cardiomyocytes....
Colorectal cancer (CRC) represents one of the most prevalent malignancies and third leading cause death worldwide. Inorganic pyrophosphatase (PPA1) is an enzyme that catalyzes hydrolysis pyrophosphate to inorganic phosphate, therefore participates in energy metabolism. Proteomic studies have demonstrated up-regulated expression PPA1 various tumors, however, its pattern CRC hasn't been reported. In current study, we used RT-qCR, Western Blot immunohistochemical (IHC) staining explore 113...
Abstract Objective This study was designed to assess the clinical presentation of patients with H‐type hypertension who were Zhuang nationality in Guangxi, China. The relationship between C677T polymorphism MTHFR gene and also assessed. Methods a case‐control which 185 that had been hospitalized at Wuming Hospital Guangxi Medical University February 2018 December assessed for plasma homocysteine (Hcy) levels. These levels used divide into (>15 μmol/L) non‐H‐type (≤15 groups. Patient data...
The aim of this work was to investigate the prevalence and specificities red blood cell (RBC) alloantibodies in general hospitalised population Guangxi, China.Alloimmunisation RBC antigens is a major complication transfusion therapy, pose many clinical problems such as transfusion-related adverse reactions. frequency specificity erythrocyte were different populations from geographic areas races. However, data on Guangxi are limited; thus, we aimed them study.Erythrocyte request records...
Breast cancer is a leading type of malignant tumor in women; however, the immunotherapy breast still underappreciated. In this study, we demonstrated that necrosis factor receptor 2 (TNFR2) highly expressed both tissue and tumor-infiltrating immunosuppressive CD4+Foxp3+ regulatory T cells (Tregs). We found TNFR2 antagonistic antibody reduced Foxp3 expression proliferation Tregs impaired inhibitory effect on CD4+CD25- effector (Teff) dose-dependent manner. The treatment anti-TNFR2 not only...
Formulae of estimated glomerular filtration rate (eGFR) based on serum creatinine (Scr) are routinely used in oncology patients, however, they inaccurate some populations. Our aim was to assess the agreement eGFR formulae and thereby build a nomogram predict reliability estimates.
Comment Preferred Regimens provide by expert group were adjusted: (1) Fluorouracil and cisplatin was no longer the Regimen for Preoperative Chemoradiation Perioperative Chemotherapy (recommended as other regimens); (2) DCF modifications First-Line Therapy (3) Pembrolizumab (For second-line or subsequent therapy MSI-H dMMR tumors) recommended Second-Line Subsequent Therapy; (4) Ramucirumab adenocarcinoma (category 1 EGJ adenocarcinoma; category 2A esophageal adenocarcinoma) Therapy. Survivors...
Abstract The major clinical challenge in lung cancer immunotherapy is drug resistance. Therefore, establishing efficient orthotopic mouse models to explore the mechanisms of resistance highly important. In this study, we generated multiple fluorescently labeled adenocarcinoma cell lines from a genetically engineered KPZ mice model. Orthotopic transplantation primary 1F3 line induced strong immune response, causing many small tumors disappear, but some evaded attack and eventually formed...
Abstract Background The electrophysiology algorithm for localizing left or right origins of outflow tract ventricular arrhythmias (OT‐VAs) with lead V 3 transition still needs further investigation in clinical practice. Hypothesis Lead I R‐wave amplitude is effective distinguishing the origin OT‐VAs transition. Methods We measured 82 OT‐VA patients and a positive complex who underwent successful catheter ablation from (RVOT) (LVOT). optimal threshold was identified, compared 2 S/V R index,...