A5028432676- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Delphi Technique in Research
- Head and Neck Cancer Studies
- Astro and Planetary Science
- Respiratory viral infections research
- Astrophysics and Star Formation Studies
- Lung Cancer Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Inhalation and Respiratory Drug Delivery
- School Health and Nursing Education
- Salivary Gland Tumors Diagnosis and Treatment
- Stellar, planetary, and galactic studies
University of Calgary
2018-2025
Hunter Medical Research Institute
2018-2023
Alberta Health Services
2018
John Hunter Hospital
2018
University of Saskatchewan
2013
Canadian Institute for Theoretical Astrophysics
2007
University of Toronto
2007
Radial velocity surveys find Jupiter-mass planets with semimajor axes a less than 0.1 AU around ~1% of solar-type stars; counting as large 5 AU, the fraction stars having reaches ~10% (as found by Marcy et al. and Butler al.). An examination distribution shows that there is clear excess orbital periods 3 or 4 days, corresponding to ≈ 0.03 sharp cutoff at shorter (see Fig. 1). It believed form distances from their parent some then migrates in produce short-period objects. We argue significant...
The combination of asthma and chronic obstructive pulmonary disease (COPD) in an individual can present significant challenges to achieving satisfactory outcomes. More recently, the concepts precision medicine treatable traits have arisen as promising tools improve care for this group. In series, we three cases patients with features both COPD addition peripheral blood eosinophilia. novel implementation personalized management based on trait (eosinophilia) resulted benefits. These benefits...
Introduction Biomarkers are used to select biologic therapies for patients with severe asthma, but not regularly adjust therapy, especially oral corticosteroids (OCS). Objective Our goal was test the efficacy of an algorithm guide titration OCS using blood eosinophil count and fraction exhaled nitric oxide (FeNO) levels. Design, participants, interventions setting This proof-of-concept prospective randomised controlled trial assigned adult participants uncontrolled asthma (n=32)...
Abstract Background Severe asthma is a complex heterogeneous disease typically requiring advanced therapies. Underlying the treatment of all asthma, however, consistent recommendation across international guidelines to ensure that adherence therapy adequate. Currently, there no consensus on an objective marker adherence. Methods We performed prospective observational study 17 participants taking oral prednisolone using serum levels as adherence, and sputum eosinophilia control type 2 airway...
Rationale: Guidelines recommend biomarker testing to phenotype patients with severe asthma (SA), guide treatment. However, levels fluctuate, and individual responses biologics are not fully understood.
RATIONALE A comprehensive understanding of the burden illness and management strategies for severe asthma (SA), especially by disease control, is lacking in Canada.
Proper staging of the mediastinum is an essential component lung cancer evaluation. Positron emission tomography-computed tomography (PETCT) and endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) are integral part this process. False-positive PETCT results can occur following surgical procedures but has not been demonstrated EBUS-TBNA. We aimed to determine whether false-positive rates increase when EBUS-TBNA performed prior PETCT.A retrospective review was carried out...
Abstract Background Severe asthma is a complex heterogeneous disease typically requiring advanced therapies. Underlying the treatment of all asthma, however, consistent recommendation across international guidelines to ensure that adherence therapy adequate. Currently, there no consensus on an objective marker adherence.Methods We performed prospective observational study 17 participants taking oral prednisolone using serum levels as adherence, and sputum eosinophilia control type 2 airway...
<b>Asthma specialists are interested in adopting biomarkers into clinical practice, but more work needs to be done support resources towards their use and provide clearer direction on this. This concern is not limited European specialists.</b>https://bit.ly/2WWEQXb
<b>Introduction:</b> Biomarkers are used to select patients for therapy in severe asthma, but not regularly adjust therapy, especially oral corticosteroids (OCS). Our goal was test the efficacy of an algorithm guide titration OCS adults with asthma using blood eosinophil count and fraction exhaled nitric oxide levels (FeNO). <b>Methods:</b> This proof-of-concept randomized controlled trial assigned participants (n=32) inflammation arm; where dose adjusted based on FeNO, or a best-practice...