A5003633153- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Occupational exposure and asthma
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Indoor Air Quality and Microbial Exposure
- Air Quality and Health Impacts
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Occupational Health and Safety Research
- IL-33, ST2, and ILC Pathways
- Antifungal resistance and susceptibility
- Occupational and environmental lung diseases
- Pharmaceutical studies and practices
- Delphi Technique in Research
- Cystic Fibrosis Research Advances
- Noise Effects and Management
- Atomic and Subatomic Physics Research
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Contact Dermatitis and Allergies
- Advanced MRI Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
Manchester Academic Health Science Centre
2013-2022
University of Manchester
2013-2022
Manchester University NHS Foundation Trust
2013-2022
Wythenshawe Hospital
2007-2021
NIHR Manchester Biomedical Research Centre
2016-2021
Manchester University
2006-2021
Respiratory Clinical Trials
2021
CarbonCure Technologies (Canada)
2021
Aston University
2019
University Hospital Southampton NHS Foundation Trust
2019
Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy applied to the airway wall decrease smooth muscle.To evaluate effectiveness and safety of BT versus sham subjects with severe asthma who remain symptomatic despite treatment high-dose inhaled corticosteroids long-acting beta(2)-agonists.A total 288 adult (Intent-to-Treat [ITT]) randomized or control underwent three bronchoscopy procedures. Primary outcome was difference Asthma Quality Life...
Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined effect bronchial on control moderate or severe persistent asthma.We randomly assigned 112 subjects who had been treated with inhaled corticosteroids long-acting beta2-adrenergic agonists (LABA) in whom asthma was impaired when LABA were withdrawn either group. The primary outcome frequency mild exacerbations, calculated during three scheduled 2-week...
Bronchial thermoplasty (BT) is designed to reduce airway smooth muscle and improve asthma control.This study was conducted determine the safety efficacy of this procedure in subjects with symptomatic, severe asthma.Adults who were symptomatic despite treatment fluticasone or equivalent at more than 750 mug/day, a long-acting beta(2)-agonist, other medications, which could include 30 mg less oral prednisolone/day, randomized BT control group. After treatment, entered 16-week steroid stable...
Pre-clinical data demonstrate a pivotal role for interleukin (IL)-13 in the development and maintenance of asthma. This study assessed effects tralokinumab, an investigational human IL-13-neutralising immunoglobulin G4 monoclonal antibody, adults with moderate-to-severe uncontrolled asthma despite controller therapies. 194 subjects were randomised to receive tralokinumab (150, 300 or 600 mg) placebo subcutaneously every 2 weeks. Primary end-point was change from baseline mean Asthma Control...
Some patients with severe asthma are immunologically sensitized to one or more fungi, a clinical entity categorized as fungal sensitization (SAFS). It is not known whether SAFS responds antifungal therapy.To evaluate the response of oral itraconazole.Patients at least seven fungi by skin prick specific IgE testing were recruited. All had total less than 1,000 IU/ml and negative Aspergillus precipitins. They treated itraconazole (200 mg twice daily) placebo for 32 weeks, follow-up 16...
<h3>Objective</h3> To determine the prevalence of systemic corticosteroid-induced morbidity in severe asthma. <h3>Design</h3> Cross-sectional observational study. <h3>Setting</h3> The primary care Optimum Patient Care Research Database and British Thoracic Society Difficult Asthma Registry. <h3>Participants</h3> (7195 subjects three age- gender-matched groups)—severe asthma (Global Initiative for (GINA) treatment step 5 with four or more prescriptions/year oral corticosteroids, n=808),...
Ex vivo, bronchial epithelial cells from people with asthma are more susceptible to rhinovirus infection caused by deficient induction of the antiviral protein, IFN-β. Exogenous IFN-β restores activity.To compare efficacy and safety inhaled placebo administered after onset cold symptoms prevent or attenuate respiratory viruses.A total 147 on corticosteroids (British Thoracic Society Steps 2-5), a history virus-associated exacerbations, were randomized 14-day treatment (n = 72) 75) within 24...
Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel variants associated with asthma, see whether previously identified for all types of contribute and provide mechanistic insights using expression analyses in patients asthma.In this genome-wide association study, we used a two-stage case-control design. In stage 1, genotyped patient-level data from two UK cohorts (the Genetics Asthma Severity Phenotypes [GASP] initiative the Unbiased BIOmarkers...
Section:ChooseTop of pageAbstract <<METHODSRESULTSDISCUSSIONCONCLUSIONSReferencesCITING ARTICLES
<h3>BACKGROUND</h3> Patients with cystic fibrosis have several risk factors for the development of low bone mineral density (BMD). To identify prevalence and clinical correlates BMD in adult patients fibrosis, densitometry was performed 151 (83 men) aged 15–52 years. <h3>METHODS</h3> measured lumbar spine (L1–4) using dual energy<i>x</i> ray absorptiometry (DXA) quantitative computed tomography (QCT). It also proximal femur (total hip femoral neck) DXA, distal ultra forearm single energy...
<h3>Background</h3> The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild moderate disease and risk factors severe remain unclear. <h3>Objective</h3> To identify common variants affecting susceptibility asthma. <h3>Methods</h3> A genome-wide study was undertaken in 933 European ancestry individuals with based Global Initiative Asthma (GINA) criteria 3 or above 3346 clean controls. After standard quality control...
Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years evaluate long-term safety of this procedure.Patients enrolled in the Asthma Intervention Research Trial were on inhaled corticosteroids ≥200 μg beclomethasone or equivalent + long-acting-beta2-agonists and demonstrated worsening long-acting-β2-agonist withdrawal. Following initial evaluation at 1 year, subjects...
Severe refractory asthma poses a substantial burden in terms of healthcare costs but relatively little is known about the factors which drive these costs. This study uses data from British Thoracic Society Difficult Asthma Registry (n=596) to estimate direct treatment an National Health Service perspective and examines that explain variations Annual mean among severe patients were £2912 (SD £2212) £4217 £2449). Significant predictors FEV<sub>1</sub>% predicted, location care, maintenance...
It has been shown that patients with allergic bronchopulmonary aspergillosis (ABPA) and severe asthma fungal sensitization (SAFS) can benefit from antifungal therapy. is not known whether allergy skin prick tests (SPT) or specific IgE are more sensitive in the identification of who sensitized to fungi therefore candidates for therapy.To compare SPT serum asthma.We have undertaken six (Aspergillus fumigatus, Candida albicans, Penicillium notatum, Cladosporium herbarum, Alternaria alternata...
<h3>Introduction</h3> Refractory asthma represents a significant unmet clinical need where the evidence base for assessment and therapeutic management is limited. The British Thoracic Society (BTS) Difficult Asthma Network has established an online National Registry to standardise specialist UK difficult services facilitate research into of asthma. <h3>Methods</h3> Data from 382 well characterised patients, who fulfilled American definition refractory attending four centres—Royal Brompton...
To cite this article: Menzies D, Holmes L, McCumesky G, Prys-Picard C, Niven R. Aspergillus sensitization is associated with airflow limitation and bronchiectasis in severe asthma. Allergy 2011; 66: 679–685. Background: Abnormalities, including bronchiectasis, that are detectable on high-resolution computed tomography (HRCT) have been Bronchiectasis the diagnosis of allergic bronchopulmonary aspergillosis (ABPA), which also occurs patients We sought to determine frequency pattern HRCT...
Rationale and objectives. Severe asthma with fungal sensitization (SAFS) allergic bronchopulmonary aspergillosis (ABPA) are progressive lung diseases whose effective treatment remains to be established. Current itraconazole is associated a 40% failure rate adverse events (AEs). We assessed the effect of voriconazole or posaconazole as second- third-line therapies. Methods. conducted retrospective review adult asthmatic patients either ABPA SAFS receiving posaconazole. Clinical, radiological,...