A5103242189- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Musculoskeletal synovial abnormalities and treatments
- Acute Myeloid Leukemia Research
- Sarcoma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Immune cells in cancer
- Erythrocyte Function and Pathophysiology
- Plant and Fungal Interactions Research
- HER2/EGFR in Cancer Research
- NF-κB Signaling Pathways
- Multiple Myeloma Research and Treatments
- Antimicrobial Peptides and Activities
- Flame retardant materials and properties
- Peroxisome Proliferator-Activated Receptors
- Muscle Physiology and Disorders
- T-cell and B-cell Immunology
- Blood groups and transfusion
- Adipokines, Inflammation, and Metabolic Diseases
- Microfluidic and Bio-sensing Technologies
- Cancer Immunotherapy and Biomarkers
- Food Allergy and Anaphylaxis Research
- Cardiovascular Disease and Adiposity
- Pediatric health and respiratory diseases
Leipzig University
2025
Fraunhofer Institute for Cell Therapy and Immunology
2018-2024
Roche Pharma AG (Germany)
2014-2023
University of Bayreuth
2018-2020
German National Bone Marrow Donor Registry
2015
TU Dresden
2015
University of Tübingen
2013
European Society for Blood and Marrow Transplantation
2007
Max Planck Institute for the Science of Human History
2002
Human adipose depots are functionally distinct. Yet, recent single-nucleus RNA sequencing (snRNA-seq) analyses largely uncovered overlapping or similar cell-type landscapes. We hypothesized that adipocyte subtypes, differentiation trajectories and/or intercellular communication patterns could illuminate this depot similarity–difference gap. For this, we performed snRNA-seq of human subcutaneous visceral tissues (five ten samples, respectively). Of 27,665 nuclei in both depots, most were...
Abstract Engineering functional skeletal muscle tissue is an ongoing challenge because of the complexity in vivo microenvironment and various factors that contribute to development maintenance native tissue. However, growing understanding natural muscle's vivo, as well ability successfully reproduce these vitro, are contributing formation engineered tissues (SMTs) with greater biomimetic structure function. This review first summarizes The role hydrogels, biomaterials, scaffolds building...
Abstract Interferon alpha (IFNa) is recognized for its potential in cancer immunotherapy by activating immune responses against tumor cells. However, untargeted IFNa's application limited systemic toxicity and non-specific activity, affecting both healthy tissues resulting undesirable side effects. To overcome these challenges, we developed the novel trivalent bispecific antibody-cytokine fusion protein RO7694744 designed to provide a specific activation of IFNa on programmed cell death...
3005 Background: Tumor associated macrophages (TAM) suppress anti-tumor immunity and have been with poor prognosis in several types of cancer. CSF-1 is a critical survival differentiation factor for TAM. Preclinically, TAM depletion has shown to enhance/restore the activity clinically established treatment modalities also novel immunotherapies. Here, we report on phase I study monoclonal antibody (RG7155) that blocks dimerization interface CSF1 receptor (CSF1R). Methods: In this...
Targeted biological therapies may achieve maximal therapeutic efficacy at doses below the maximum tolerated dose (MTD); therefore, search for MTD in clinical studies not be ideal these agents. Emactuzumab is an investigational monoclonal antibody that binds to and inhibits activation of cell surface colony‐stimulating factor‐1 receptor. Here, we show how modeling target‐mediated drug disposition coupled with pharmacodynamic end points was used optimize emactuzumab without defining MTD. The...
Abstract Introduction: FAP-DR5 (RO6874813) is a novel bispecific antibody that binds with high and low affinity to fibroblast activation protein (FAP) death receptor 5 (DR5), respectively. FAP-driven binding of RO6874813 mediates the levels DR5 clustering are required for triggering cell death. Here, we present ongoing phase 1 data in patients advanced solid tumors who were treated escalating doses single agent assessed tolerability. Methods: Study endpoints safety tolerability (primary)...
Introduction: The antibody-like fusion protein RO7227166 simultaneously targets CD19 on B-cells and 4-1BB (CD137) T cells. activity is strictly dependent crosslinking exhibits no single-agent activity. plus glofitamab shows strong synergy in preclinical models being developed for patients (pts) with relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL). Methods: This first-in-human trial BP41072 (NCT04077723) evaluated the safety, tolerability, pharmacokinetics/dynamics preliminary of...
10504^ Background: PVNS, also known as tenosynovial giant cell tumor (TGCT), is a rare disease mainly affecting young adults. This neoplastic driven in most cases by t(1;2) translocation resulting fusion of COL6A3 and M-CSF genes encoding for colony-stimulating factor 1 (CSF1). The bulk mass consists CSF1 receptor (CSF1R) positive cells. RG7155 monoclonal antibody that potently inhibits the dimerization CSF1R. Methods: In this dose-escalation –extension phase I study, we treated patients...
Cell transplantation and stem cell therapy are promising approaches for regenerative medicine of interest to researchers clinicians worldwide. However, currently, no imaging technique that allows three-dimensional in vivo inspection therapeutically administered cells host tissues is available. Therefore, we investigate magnetomotive optical coherence tomography (MM-OCT) labeled with magnetic particles as a potential noninvasive tracking method. We develop mesenchymal future monitoring. Cells...
To evaluate the invasive potential of early tumorous lesions breast, especially DCIS, we have analyzed semiquantitative telomerase activity in well defined microdissected tissue areas from malignant or benign breast 145 patients. In order to prove relationship cell cycle defects, p53 and p21 proteins were corresponding cryostat sections by immunohistochemistry. Telomerase was detected 3 (33.3%) out 9 109 (80.1%) 136 tumors. Our study failed demonstrate an association between activity, p21,...
Hematopoietic stem cell transplantation is a multifactorial process. Some of the predictors exhibit time-dependent effects. We present systematic analysis and description selected clinical influencing outcome in manner based on an registry data from German Registry for Stem Cell Transplantation. A total 14,951 patients with acute myeloid leukemia, lymphocytic myelodysplastic syndrome non-Hodgkin lymphoma transplanted peripheral blood cells or bone marrow grafts were included. Multivariate...
Despite the constant development of innovative therapeutic options for hematological malignancies, gold-standard therapy regimen curative treatment often includes allogeneic hematopoietic stem cell transplantation (HSCT). The graft-versus-leukemia effect (GVL) is one main goals that arises from HSCT. On other hand, graft-versus-host disease (GVHD) still and most serious complications following In acute myeloid leukemia (AML), HSCT together with high-dose chemotherapy used as a option. An...
The aryl hydrocarbon receptor (AhR) and the peroxisome proliferator-activated γ (PPARγ) are ligand-activated transcription factors that have in recent years been investigated for their anti-inflammatory properties treatment of inflammatory bowel diseases (IBDs). These globally prevalent chronic maladies gut lack cost-efficient therapeutical options capable inducing long-term remission. In present study, we used an vitro Transwell
The mechanisms underlying the impaired immune response in hemodialysis (HD) patients are not completely understood. α-defensins human neutrophil peptides-1, 2, and 3 low molecular weight peptides with antimicrobial activity important effector molecules of innate responses. We now examined expression these HD patients. Seventy-six on chronic treatment (mean time 5.8 years; mean age 70 years) were studied compared 38 healthy volunteers 20 infections normal renal function. Expression was...