A5011282654- Immune Response and Inflammation
- S100 Proteins and Annexins
- Mycotoxins in Agriculture and Food
- Essential Oils and Antimicrobial Activity
- Heavy Metal Exposure and Toxicity
- Biomarkers in Disease Mechanisms
- Heavy metals in environment
- Insect Pest Control Strategies
- Wheat and Barley Genetics and Pathology
- Peroxisome Proliferator-Activated Receptors
- Inflammatory Bowel Disease
- Fungal Biology and Applications
- Pesticide Exposure and Toxicity
- Heavy Metals in Plants
- Cholinesterase and Neurodegenerative Diseases
- NF-κB Signaling Pathways
- Vitamin K Research Studies
- Coronary Interventions and Diagnostics
- Carcinogens and Genotoxicity Assessment
- Calpain Protease Function and Regulation
- Parasitic Infections and Diagnostics
- Laser Applications in Dentistry and Medicine
- Barrier Structure and Function Studies
- Environmental and Social Impact Assessments
- Ginger and Zingiberaceae research
Fraunhofer Institute for Cell Therapy and Immunology
2024-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2023
Instituto do Coração
2023
Universidade de São Paulo
2017-2022
Universidade Estadual de Maringá
2011-2021
The antifungal and antiaflatoxigenic properties of Thymus vulgaris essential oil (TEO) were evaluated upon Aspergillus flavus "in vitro". Suspension containing 106 A. cultivated with TEO in concentrations ranging from 50 to 500 μg/mL. reached minimum inhibitory concentration (MIC) fungicidal (MFC) at 250 Inhibition ergosterol biosynthesis was detected a 100 μg/mL TEO. Morphological evaluation performed by both light microscopy scanning electron showed that activity could be starting the...
A controlled cross-sectional study of family growers fruit and vegetables was conducted between October 2009 2010 to characterize the use pesticides, establish socio-demographic profile, analyze cholinesterase activity in small-scale agricultural workers Southern Brazil. Data collected for 173 179 controls. structured questionnaire applied collecting information determining knowledge work practices relation pesticide use. The benchmarks total (ChEs) butyrylcholinesterase (BuChE) were...
ABSTRACT: Essential oils are possible alternatives to the use of synthetic pesticides for control fungal contamination. Ginger (Zingiber officinale) essential oil (GEO) is known having antifungal and antiaflatoxigenic properties, but its as a fumigant in situ has not been studied yet. The aim this study was evaluate GEO’s effects upon Aspergillus flavus agent stored maize grains. main compounds reported GEO were α-zingiberene (23.85%) geranial (14.16%), characterized by gas...
Abstract Background Inflammatory Bowel Diseases (IBD) lack therapeutic options capable of inducing long-term remission in a cost-efficient manner. Repurposing strategies have allowed already established receptors and ligands to be tested as alternative pharmacotherapy for treatment IBD. Agonists the aryl hydrocarbon receptor (AhR), ligand-dependent transcription factor traditionally associated with xenobiotic toxicity, been explored potential anti-inflammatory drugs treat IBD, but specific...
Summary In this study, the efficacy of g inger ( Zingiber officinale Roscoe) essential oil GEO ) in reducing A. flavus growth and aflatoxin production was investigated. Gas chromatography coupled to mass spectrometry nuclear magnetic resonance spectroscopy showed that major components were α‐zingiberene (23.85%) geranial (14.16%). Mycelial Aspergillus reduced significantly at a concentration 150 μg mL −1 , complete inhibition conidial germination observed 10 . Statistically significant...
Biological mediators secreted during peripheral chronic inflammation reach the bloodstream and may damage blood-brain barrier (BBB), triggering central nervous system (CNS) disorders. Full-fledged human BBB models are efficient tools to investigate pharmacological pathways mechanisms of injury at BBB. We here employed a in vitro model effects either plasma from inflammatory bowel disease (IBD) patients or tumor necrosis factor α (TNFα), cytokine commonly released periphery IBD,...
Deoxynivalenol (DON) is the most important of trichothecenes in terms amounts and occurrence wheat. This compound was shown to be associated with a glomerulonephropathy involving an increase immunoglobulin A humans. study assessed DON wheat flour exposure Brazilian teenagers, adults elderly this mycotoxin due intake flour-based products. extraction carried out by solid phase quantification performed ultra-high proficiency liquid chromatography diode-array detection. total 77.9% all samples...
This study aimed to evaluate the antimycotoxigenic effect of essential oils (EOs) obtained from four different aromatic plants on production deoxynivalenol (DON) and zearalenone (ZEA) by
Annexin A1 (AnxA1) is a protein secreted by phagocytic cells which plays pivotal role on the resolution of inflammation enhancing phagocytosis carried out phagocytes. Which factors and intracellular mechanisms are linked to such actions exerted AnxA1 yet be completely understood. In order investigate such, BV2 microglial were transfected with plasmids aimed at down‐modulating expression also treated exogenous recombinant rAnxA1; gene proliferated‐activated receptor γ (PPARγ) CD36, STAT6...
Ulcerative colitis and Crohn’s disease are chronic inflammatory bowel diseases (IBDs) which burden health systems worldwide; available pharmacological therapies limited cost-intensive. Use of peroxisome proliferator activated-receptor γ (PPARγ) ligands for IBD treatment, while promising, lacks solid evidences to ensure its efficacy. Annexin A1 (AnxA1), a glucocorticoid-modulated anti-inflammatory protein, plays key role on control is potential biomarker progression. We here investigated...
Non-responsiveness to anti-TNF-α therapies presents relevant rates in inflammatory bowel disease patients, presenting the need find biomarkers involved therapeutic efficacy. Herein, we demonstrate that higher levels of colonic formyl peptide receptor 1 and annexin A1 correlate with histological recovery Crohn’s patients under remission. Using dextran sulfate sodium colitis model mice, suggest infliximab induces expression secretion activated intestinal leukocytes. Conversely, this mechanism...
Abstract The purpose of this study was to assess the risk zearalenone (ZEA) in corn meal produced and commercialized State Parana, Brazil. extraction method carried out with a Romer Mycosep 226 column found be efficient due addition both diatomaceous earth centrifuging during cleaning step. From total 84 analyzed samples, 78.6% ( n = 66) were contaminated ZEA at levels between 15.4 72.1 μg/kg. This first report on occurrence positive samples for Parana since 2005. estimated daily intake...
The aim of this study was to evaluate the effects thymol and carvacrol upon production aflatoxins by Aspergillus flavus its growth. Minimal inhibitory concentration (MIC), fungitoxic spectrum mycotoxin inhibition were assessed. Results showed exhibited fungicidal action, as determined MIC values 2500 30 µg mL-1, respectively. Both significantly inhibited growth A. (p
COVID-19, caused by the SARS-CoV-2 virus, is a global respiratory syndrome with high mortality rates. Vaccination currently only proven method to prevent disease, although role of lab data in assessing efficacy remains uncertain. This study aimed assess spike-binding and neutralizing antibody levels following full vaccination Oxford/AstraZeneca (ChAdOx1 nCoV-19) or CoronaVac healthcare workers southeastern Brazil. ChAdOx1 nCoV-19 induced IgG antibodies against trimeric spike glycoproteins...
The aryl hydrocarbon receptor (AhR) and the peroxisome proliferator-activated γ (PPARγ) are ligand-activated transcription factors that have in recent years been investigated for their anti-inflammatory properties treatment of inflammatory bowel diseases (IBDs). These globally prevalent chronic maladies gut lack cost-efficient therapeutical options capable inducing long-term remission. In present study, we used an vitro Transwell
The aim of this study was to determine concentrations metals in peel, pulp, and seeds grapes obtained from family farms Brazil, compare them the maximum threshold levels evaluate risk by estimating daily intake (EDI). Grape samples were collected Cd, Cr, Cu, Mn, Ni, Pb Zn assessed via ICP-MS. highest metal found grape peels, Cu at concentration (107.6 mg kg-1). which exceeded levels. EDI through consumption for Brazilian population 0.29, 1822 3.02 µg/kg bw/day, respectively. above...