A5006985315- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Stoma care and complications
- Autoimmune and Inflammatory Disorders
- Pancreatitis Pathology and Treatment
- Eosinophilic Esophagitis
- Liver Disease and Transplantation
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Reforms
- Immunodeficiency and Autoimmune Disorders
- Biosimilars and Bioanalytical Methods
- Liver Diseases and Immunity
- Clostridium difficile and Clostridium perfringens research
- COVID-19 and healthcare impacts
- Alcohol Consumption and Health Effects
- COVID-19 Clinical Research Studies
- Infant Nutrition and Health
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Blood properties and coagulation
- Mast cells and histamine
- Pneumocystis jirovecii pneumonia detection and treatment
- Pregnancy and Medication Impact
- Barrier Structure and Function Studies
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2014-2025
Irmandade da Santa Casa de Misericórdia de São Paulo
2009-2023
Universidade Federal do Ceará
2021
Santa Casa Hospital
2015
Frequentis (Germany)
2014
Ambiente Italia (Italy)
2014
Hospital de São Bernardo
2011
Faculdade de Medicina do ABC
1999
Research has shown that fecal biomarkers are useful to assess the activity of inflammatory bowel disease (IBD). The aim study is: evaluate efficacy lactoferrin and calprotectin as indicators activity.A total 78 patients presenting were evaluated. Blood tests, Crohn's Disease Activity Index (CDAI), Mayo (MDAI), Endoscopic Severity (CDEIS) used for clinical endoscopic evaluation. Two tests performed on samples, check levels lactoferrin. performance these markers detection inflammation with...
To assess the real-life, long-term effectiveness and safety of tofacitinib in a large cohort patients with refractory or difficult-to-treat ulcerative colitis (UC). This multicenter, retrospective, observational study included moderately to severely active UC who received for at least 8 weeks. Clinical remission response, endoscopic response remission, biochemical steroid-free clinical primary secondary loss drug discontinuation, need dose optimization, colectomy, adverse events were...
A evolução dos recursos eletrônicos no ensino iniciou com computadores e projetores, progrediu para plataformas online aplicativos, hoje inclui realidade virtual aumentada. mudança envolveu a adaptação de métodos tradicionais, chegada programas simulação materiais didáticos digitais. As ferramentas digitais aprimoram o ao tornar conceitos abstratos mais acessíveis por meio simulações ambientes virtuais. Apesar das vantagens, ambiente digital traz desafios, como sobrecarga informações, dados...
Biological mediators secreted during peripheral chronic inflammation reach the bloodstream and may damage blood-brain barrier (BBB), triggering central nervous system (CNS) disorders. Full-fledged human BBB models are efficient tools to investigate pharmacological pathways mechanisms of injury at BBB. We here employed a in vitro model effects either plasma from inflammatory bowel disease (IBD) patients or tumor necrosis factor α (TNFα), cytokine commonly released periphery IBD,...
Persons with inflammatory bowel disease (IBD) may be particularly vulnerable to COVID-19 either because of their underlying or its management. Guidance has been presented on the management persons IBD in time this pandemic by different groups. We aimed determine how gastroenterologists around world were approaching IBD.
To investigate the association between nonalcoholic fatty liver disease (NAFLD) and cancer, NAFLD prevalence in different tumors.This is a retrospective study of clinical, laboratory histological data 120 patients diagnosed with primary or secondary hepatic neoplasms treated at tertiary center where they underwent resection and/or transplantation, subsequent evaluation explant biopsy. The following criteria were used to exclude from study: history alcohol abuse, hepatitis B C infection, no...
The etiology of inflammatory bowel disease (IBD) is unknown, but it believed to be multifactorial. hygiene hypothesis proposes that better conditions would lead less infectious during childhood and favor the development immune-mediated diseases.To test in IBD by assessing environmental risk factors associated with different regions Brazil diverse socioeconomic indices.A multicenter case-control study was carried out 548 Crohn's (CD) 492 ulcerative colitis (UC) outpatients 416 healthy...
Objective. Liver biopsy (LB) remains the gold standard for assessment of liver fibrosis, although it is invasive and can have complications. The present study compares several noninvasive methods fibrosis in chronic hepatitis C (CHC), including acoustic radiation force impulse (ARFI) elastography, aspartate aminotransferase:platelet ratio index (APRI), Forns, FIB-4, King scores versus percutaneous LB. Material methods. This prospective enrolled 51 untreated CHC patients. Biological tests...
Non-responsiveness to anti-TNF-α therapies presents relevant rates in inflammatory bowel disease patients, presenting the need find biomarkers involved therapeutic efficacy. Herein, we demonstrate that higher levels of colonic formyl peptide receptor 1 and annexin A1 correlate with histological recovery Crohn’s patients under remission. Using dextran sulfate sodium colitis model mice, suggest infliximab induces expression secretion activated intestinal leukocytes. Conversely, this mechanism...
Therapeutic drug monitoring (TDM) during induction therapy with anti-tumor necrosis factor drugs has emerged as a strategy to optimize response these biologics and avoid undesired outcomes related inadequate exposure. This study aimed describe clinical, biological, endoscopic remission rates at six months in Brazilian inflammatory bowel disease (IBD) patients following proactive TDM algorithm guided by IFX trough levels (ITL) antibodies (ATI) induction, week six. A total of 111 IBD were...
Mean age (y) (m±sd) 35±17 34.3±16 39.3±12 40.1±2 <0.05 Disease duration (m) 97±99 90±98 145±120 115±90 Body Mass Index 21.6±3.8 21.6±4.3 24.3±4.3 25.1±6.3 0.001 Intestinal resection (%) 10 (14.9) 19 (21.8) 15 (48.4) 31 (40) 0.002 No biotherapy 13 (19.4) 23 (26.4) 11 (35.5) 52 (53.6) 0.0001 Biotherapy, previous/current/after 26/18/10 38/21/5 18/1/1 40/3/2 Harvey Bradshaw 7.4±5.3 7.1±4.8 3.1±2.9 3.9±3.7 PDAI 6.1±4.4 9.5±5 2.9±3.6 0±1 Anal stenosis 12 (17.9) 28 (32.1) 6 3 (3.1)
INTRODUÇÃO: há uma preocupação crescente com os custos da terapia biológica no tratamento DC. O objetivo deste estudo foi simular o custo-minimização do contínuo IFX e ADA em portadores de DC, num período 1 ano, variadas faixas peso. MÉTODO: farmacoeconômico na simulação agentes biológicos pacientes pesos diferentes. Os foram baseados preço dos dois medicamentos isoladamente (IFX E ADA). RESULTADOS: custo (sistema público) R$ 29.411,12 (entre 20 40 kg), 44.116,68 41 60 58.822,24 61 80 kg)...
Alcohol relapse after transplantation is a serious concern in transplant centers and subject of controversy debate.To evaluate the alcohol ingestion eventual associated factors cirrhotic patients referred for liver transplantation.A retrospective study comprised 90 adult with cirrhosis, listed transplant. The exclusion criteria were: not having at least 6 months abstinence release approved by psychology team. diagnosis (ingestion any quantity alcohol) was done based on information histories...
Introduction: Adalimumab (ADA) is a subcutaneous fully-human anti-TNF antibody which has significant role in the management of Crohn's disease (CD). Its efficacy been demonstrated several clinical trials. The main objective this study was to evaluate ADA induction remission Brazilian series CD cases. Method: A retrospective analysis patients treated with performed three inflammatory bowel diseases (IBD) reference centers. following characteristics were analyzed: gender, age, indication...
Identifying significant fibrosis is crucial to evaluate the prognosis and therapeutic interventions in patients with nonalcoholic fatty liver disease (NAFLD). We assessed performance of acoustic radiation force impulse (ARFI) elastography, APRI, FIB-4, Forns, NFS BARD scores determining severe obesity.A prospective study included 108 undergoing bariatric surgery. Liver biopsy specimens were obtained intraoperatively classified according NAFLD Activity Score. Patients serological markers...
Hepatopulmonary Syndrome (HPS) is a chronic and irreversible disease caused by systemic changes associated with portal hypertension, which greatly compromises patients' expectations quality of life. It an increase in morbidity mortality regardless the degree liver dysfunction. Data on accuracy diagnosis HPS cirrhosis limited. This study aimed to analyze prevalence cirrhotic patients at our service correlate it oxygen saturation (SatO2) using pulse oximeter evaluate if this useful as...