A5082068188- Inflammatory Bowel Disease
- Autoimmune and Inflammatory Disorders
- Microscopic Colitis
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Stoma care and complications
- Anorectal Disease Treatments and Outcomes
- Gastric Cancer Management and Outcomes
- Hidradenitis Suppurativa and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Diagnosis and treatment of tuberculosis
- Biliary and Gastrointestinal Fistulas
- Pelvic floor disorders treatments
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Surgical Treatments
- Chemotherapy-related skin toxicity
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Vitamin K Research Studies
- Tumors and Oncological Cases
- Genetic factors in colorectal cancer
- Hernia repair and management
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
Hospital Heliópolis
2013-2023
Hospital São Paulo
2011-2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2021
Hospital do Mar
2005
Author note: TY, AS, YS, FVT and PGK designed the study. All authors did data collection gave scientific contribution to study design discussion. AS drafted article. read approved final version of manuscript.In era biologic agents, risk factors for complications following resection Crohn's disease have not been fully identified. In particular, association preoperative use immunosuppressive agents with incidence after remains be elucidated.This retrospective multicentre aimed identify...
Abstract Aim Early endoscopic recurrence is frequently observed in patients following resection for Crohn's disease (CD). However, factors affecting the incidence of an early postoperative (EPER) have not been fully determined. The aim this study was to evaluate risk EPER after ileocolonic CD. Method This a retrospective, international multicentre study, which 127 with first ileocolonoscopy conducted between 6 and 12 months CD were included. Endoscopic defined as Rutgeerts score ≥ i2....
Background Perianal fistulizing Crohn’s disease is one of the most severe phenotypes inflammatory bowel diseases. Combined therapy with seton placement and anti-TNF common strategy for this condition Objectives The aim study was to analyze rates complete perianal remission after combined disease. Methods This a retrospective observational patients submitted from four diseases referral centers. We analyzed patients’ demographic characteristics, Montreal classification, concomitant medication,...
Both adalimumab [ADA] and infliximab [IFX] seem to be effective in the prevention of early postoperative endoscopic recurrence [EPER] after ileocaecal resection Crohn's disease [CD] patients. There is lack data with direct comparison between two agents scenario. The aim this study was compare rates EPER patients treated ADA IFX for CD. This a multicentre retrospective analysis CD resections, from seven referral centres three countries. Endoscopic defined as Rutgeerts' score ≥ i2. were...
Approximately 25% of patients with inflammatory bowel disease (IBD) develop the during childhood or adolescence and treatment aims to control active symptoms prevent long-term complications. The management Crohn's (CD) ulcerative colitis (UC) can be especially challenging in children adolescents, related particularities that may affect growth, development, puberty.This consensus provide guidance on most effective medical surgical pediatric CD UC.Experts Pediatric IBD representing Brazilian...
Background: Despite optimized medical therapy, contemporary risk of surgery in inflammatory bowel diseases (IBD) after 10 years diagnosis is 9.2% patients with ulcerative colitis (UC) and 26.2% Crohn’s disease, (CD) the biological era. Objective: This consensus aims to detail guidance most appropriate surgical procedures different IBD scenarios. In addition, it details indications perioperative management adult CD UC. Methods: Our was developed by colorectal surgeons gastroenterologists...
Currently, many patients undergoing abdominal surgery for severe and complicated Crohn's disease (CD) have been previously treated with biological therapy. The impact of anti-TNF therapy, Infliximab (IFX) Adalimumab (ADA), in surgical morbidity remains to be defined after major CD patients. aim this study was evaluate the influence biologics on early post operative complications brazilian This is a multicenter retrospective that underwent intestinal resection (stricturoplasties were...
Neoplasia colorretal é incomum em menores de 40 anos, ocorrendo numa freqüência 2,1 a 14,6%. Neste estudo retrospectivo demonstramos experiência com pacientes portadores neoplasia colorretal, submetidos tratamento cirúrgico ao longo cinco anos. Dos 453 operados por no período, 48 (10,6%) tinham anos ou menos. A faixa etária média foi 32,5 predominando sexo masculino (60,4%). O tempo médio entre o início dos sintomas e diagnóstico sete meses. História familiar positiva oito (16,7%), negativa...
Postoperative endoscopic recurrence (PER) occurs in nearly 80% of patients 1 year after ileocecal resection with Crohn's disease (CD). Biological agents were more effective reducing the rates PER comparison conventional therapy, prospective trials. The aim this study was to compare biological versus therapy resections CD real-world practice.The MULTIPER (Multicenter International Endoscopic Recurrence) database is a retrospective analysis resection, from 7 referral centers 3 different...
INTRODUÇÃO: há uma preocupação crescente com os custos da terapia biológica no tratamento DC. O objetivo deste estudo foi simular o custo-minimização do contínuo IFX e ADA em portadores de DC, num período 1 ano, variadas faixas peso. MÉTODO: farmacoeconômico na simulação agentes biológicos pacientes pesos diferentes. Os foram baseados preço dos dois medicamentos isoladamente (IFX E ADA). RESULTADOS: custo (sistema público) R$ 29.411,12 (entre 20 40 kg), 44.116,68 41 60 58.822,24 61 80 kg)...
A Síndrome de Fournier é uma fasciite necrotizante rapidamente progressiva que acomete a genitália e região perineal. Mesmo com os avanços na terapêutica, morbidade mortalidade desta afecção permanecem elevadas. É relatado caso paciente masculino, 70 anos, diagnóstico adenocarcinoma próstata avançado. Há um dia dor aumento volume escrotal associado febre. Ao exame físico, séptico gangrena gasosa do pênis escroto; ao toque retal, lesão ulcero-vegetante em parede anterior reto estendendo-se 3...
Perianal fistulizing Crohn's disease is the main risk factor for anal cancer in patients with inflammatory bowel disease. Whether this occurs due to a higher frequency of human papillomavirus remains unclear. The authors aimed evaluate prevalence HPV and high-risk perianal disease, compared control group. conducted two-center cross-sectional study which were matched age sex anorectal fistula without Biopsy specimens obtained from fistulous tracts during examination under anesthesia both...
The stricturing and fistulizing forms of Crohn's disease (CD) exhibit many different results to clinical treatment good response surgical therapy. prevalence strictures in CD ranges from 12 54% they are more frequently patients with longer duration, the terminal ileum is most commonly affected location. pharmacobezoars can be formed any part gastrointestinal tract often associated factors predisposing anatomic, functional or other concomitant conditions. pharmacological properties drugs may...
Background: The use of anti-TNFs carries a low risk developing demyelinating neuropathy and multiple sclerosis. However, in the event such occurrences, discontinuing medication is recommended to prevent progression neurological diseases. Autologous bone marrow transplantation has been performed as treatment choice for patients with sclerosis two decades, particularly refractory cases. More recently, it also considered Crohn‘s disease who show no response or have contraindications biological...
O enema opaco, apesar de atualmente apresentar indicações restritas, continua útil na propedêutica radiológica do cólon. A perfuração colorretal é a mais grave complicação ocorrendo em 0,02 0,23% dos exames realizados, com taxa mortalidade até 50%. É relatado caso paciente masculino, 40 anos, há dois meses apresentou dor anal intensa e sangramento durante realização opaco para investigação etiológica constipação, melhora espontânea após um mês. Ao exame proctológico constatou-se infiltração...
Poster presentations collagenous band thickness, and lamina propria inflammation.Hazard ratios (HR) were calculated by logistic regression analysis with 95% confidence intervals.Results: The overall symptom relapse rate was 61%.By multivariate analysis, a baseline stool frequency >5/day (HR 3.95; 1.08 14.39), history of diarrhea >12 months 1.77; 1.04 3.03), the absence budesonide maintenance therapy 2.71; 1.37 5.38) associated relapse.The time to shorter in patients (56 vs. 199 days, p =...
of EICs in a Dutch population based cohort (IBD-SL). As use immunomodulators and anti-TNF rises, we also assess the risk immunosuppression-related cancers (IRC). Methods: All IBD-SL patients diagnosed with UC between 1991 2011 were followed until 2012. Observed primary determined by scrutinizing all hospital records Pathology Database. Local incidence rates derived from Cancer Registry. Ageand sex-adjusted Standardized Incidence Ratio (SIR) calculated for overall cancer, CRC, common (i.e....
A sulfassalazina é ainda muito utilizada nas doenças inflamatórias intestinais, sobretudo na retocolite ulcerativa leve e moderada. Entretanto, seu uso relacionado a vários efeitos colaterais, incluindo disfunção hepática grave.Este um relato do caso de paciente masculino, 21 anos, portador moderada, com queixa inapetência, febre, artralgia icterícia, há sete dias. Antecedente pessoal 4 g/dia seis semanas. Ao exame físico apresentava-se ictérico, exantema em membros edema inferiores. Exames...
Introdução: o Adalimumabe (ADA) é um anticorpo monoclonal totalmente humano, utilizado no tratamento da doença de Crohn (DC). Nos casos com necessidade interrupção desta terapia, resgate resposta controverso, e papel reindução remissão dose total ataque pode ser uma alternativa nos graves DC. Não há relatos forma na literatura. O objetivo deste estudo foi relatar a experiência dois pacientes tratados ADA, após sua interrupção. Método: análise retrospectiva submetidos em meio coorte 24 uso...
Apesar dos avanços na compreensão da doença de Crohn, os fatores determinantes recidiva no pós-operatório permanecem especulativos. O objetivo deste estudo foi analisar retrospectivamente preditivos Crohn pós-operatório. Métodos: foram analisados 45 pacientes com diagnóstico submetidos ao tratamento cirúrgico, avaliando e como idade, sexo, raça, tabagismo, localização, padrão anatomo-clínico, indicação cirúrgica, tipo anastomose. Resultados: em 67,7% houve sendo a causa mais freqüente forma...
Background Crohn's disease (CD) is a chronic inflammatory and relapsing that can affect any segment of the gastrointestinal tract. A significant percentage these patients suffer an aggressive course, refractory to conventional clinical therapy . Surgery may be required, however tends recur after resection. Aim Describe potential benefit autologous hematopoietic stem cell with T-lymphocyte-depletion as treatment for CD patients. Evaluate its efficacy, safety, toxicity adverse events primary...