A5072336237- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Diverticular Disease and Complications
- Anorectal Disease Treatments and Outcomes
- Autoimmune and Inflammatory Disorders
- Stoma care and complications
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Biliary and Gastrointestinal Fistulas
- Intraperitoneal and Appendiceal Malignancies
- Healthcare during COVID-19 Pandemic
- Colorectal and Anal Carcinomas
- Medical Device Sterilization and Disinfection
- Intestinal Malrotation and Obstruction Disorders
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Screening and Detection
- Celiac Disease Research and Management
- Pelvic floor disorders treatments
- Congenital gastrointestinal and neural anomalies
- Hernia repair and management
- Hypertrophic osteoarthropathy and related conditions
- Women's cancer prevention and management
- Chemotherapy-related skin toxicity
- Hydrogen's biological and therapeutic effects
Pontifícia Universidade Católica do Paraná
2015-2025
Hospital Universitário Cajuru
2012-2023
Pontifical Catholic University of Puerto Rico
2007-2023
Universidade Federal do Rio Grande do Sul
2018
Hospital de Clínicas
2018
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018
Pontifícia Universidade Católica de São Paulo
2010-2015
Abstract Background Vedolizumab (VDZ) is an α4β7 integrin antibody used to treat moderate-to-severe ulcerative colitis (UC) and Crohn’s disease (CD). We aimed assess the real-life long-term effectiveness safety of VDZ as a first- or second-line biological therapy identify predictors efficacy in large cohort patients with refractory difficult-to-treat UC. Methods This was multicenter, retrospective observational study including moderately-to-severely active UC who received for at least 12...
ABSTRACT BACKGROUND: Inflammatory bowel diseases (IBD) are chronic inflammatory affections of recurrent nature whose incidence and prevalence rates have increased, including in Brazil. In long term, they responsible for structural damage that impacts quality life, morbidity mortality patients. OBJECTIVE: To describe the profile physicians who treat IBD patients as well characteristics care, unmet demands difficulties. METHODS: A questionnaire containing 17 items was prepared sent to 286 from...
Background: Despite optimized medical therapy, contemporary risk of surgery in inflammatory bowel diseases (IBD) after 10 years diagnosis is 9.2% patients with ulcerative colitis (UC) and 26.2% Crohn’s disease, (CD) the biological era. Objective: This consensus aims to detail guidance most appropriate surgical procedures different IBD scenarios. In addition, it details indications perioperative management adult CD UC. Methods: Our was developed by colorectal surgeons gastroenterologists...
Despite some variability in ideal serum Adalimumab (ADA) concentrations, there is increasing evidence that higher concentrations of anti-TNF-α agents can be associated with sustained efficacy, and low or undetectable levels may lead to loss response. This study aims correlate ADA clinical endoscopic activity patients Crohn’s disease (CD). A cross-sectional multicentric was performed CD, who used for at least 24 weeks. Patients were allocated into groups according the presence activity. Serum...
ABSTRACT BACKGROUND: There is scarce data regarding efficacy and safety of vedolizumab in inflammatory bowel diseases Latin America. OBJECTIVE: To describe the first observational real-world experience with American patients. METHODS: Retrospective multicentric study patients Crohn’s disease (CD) ulcerative colitis (UC) who used at any phase their treatment. Clinical remission response (according to Harvey-Bradshaw index for CD Mayo score UC), mucosal healing, need surgery adverse events...
INTRODUCTION: There is currently an increasing use of biological agents in the management Crohn's disease (CD). lack data regarding epidemiological profile patients on infliximab (IFX) and adalimumab (ADA) for CD Brazil. OBJECTIVE: To identify characteristics with who underwent therapy. METHOD: Retrospective multicenter study, Analyzed variables: gender, age at treatment initiation, Montreal classification, concomitant perianal smoking status. RESULTS: 175 without previous exposure to were...
OBJECTIVE: To evaluate the effects of topical policresulen and cinchocaine in postoperative pain behavior open hemorrhoidectomy.METHODS: We conducted a prospective, double-blinded, controlled study. The control group received usual guidelines with oral medications. treatment received, addition, application ointment was comprised two subgroups (policresulen + cinchocaine, placebo). Pain intensity recorded visual analogue scale.RESULTS: 43 patients were operated on: - n = 13, one excluded;...
The efficacy of both Infliximab (IFX) and Adalimumab (ADA) can be reduced over time. aim this study was to analyze the incidence loss (LOE) IFX ADA, outline influence disease duration on its occurrence.Retrospective, multicenter, observational cohort study, with CD patients treated anti-TNF therapy. LOE defined as need for steroids, occurrence major abdominal surgery during treatment, dose increase, interval shortening or switching anti- TNF agent. Patients were allocated in three subgroups...
Context Adalimumab is a fully-human antibody that inhibits TNF alpha, with significant efficacy for long-term maintenance of remission. Studies this agent in Latin American Crohn’s disease patients are scarce. Objectives The objective study was to outline clinical remission rates after 12 months adalimumab therapy patients. Methods Retrospective, single-center, observational Brazilian case series under therapy. Variables analyzed: demographic data, Montreal classification, concomitant...
To investigate the influence of methylene blue, on healing intestinal anastomoses subjected to ischemia and reperfusion in rats.Forty-five rats divided into following three groups were used: control (G1); without blue (G2); with (G3). A laparotomy was performed cranial mesenteric artery isolated. Whereas temporarily occluded for 45 minutes G2 G3, prior enterotomy anastomosis, group G1 anastomosis lesion. Afterwards, 2mL 0.5% instilled peritoneal cavities animals isotonic saline solution G2....
Abstract Background significant advances in medical therapy for Crohn's disease (CD) occurred the last 12 years, mainly due to introduction of anti-TNF therapy. Laparoscopic colorectal surgery represented most important advance on surgical treatment management CD, as it also had developed other conditions. There is a tendency lower complication rates after laparoscopic bowel resections compared open surgery. The aim this study was analyze and compare CD between two approaches Brazilian case...
INTRODUÇÃO: as operações anorretais correspondem a 80% do movimento coloproctologista. O índice de complicações tardias após estas é indefinido, e varia acordo com o tipo operação serviço onde são realizadas. OBJETIVO: estabelecer taxa decorrentes das fatores risco que pudessem estar associados complicações. MÉTODO: estudo retrospectivo (série casos) dos pacientes submetidos entre janeiro 2007 julho 2009. Variáveis estudadas: sexo, idade, operação, sistema saúde, técnica anestesia, tardias,...
<title>Abstract</title> Introduction: there are several studies in the literature that associate presence of higher serum concentrations infliximab (IFX) with fistula healing perianal Crohn's disease (CD). This study aimed to evaluate IFX patients fistulizing CD (PFCD) or absence general, clinical, and radiological activities deep remission. Methods: a cross-sectional PFCD during maintenance treatment from two centers. Serum were measured before its next infusion anal fistulas evaluated by...
Abstract Introduction and Objectives Certolizumab Pegol (CZP) is an anti-TNF agent approved in Brazil for Crohn's disease (CD). There a lack of data Latin America detailing real-world experiences with CZP. The primary objective was clinical remission weeks 26 54. secondary endpoints were response 54, endoscopic remission, biological switch rates, rates CD-related surgery, persistence treatment over time, adverse events. Remission defined as HBI ≤4 ≥3 points reduction HBI, respectively....
INTRODUÇÃO: a miíase é uma afecção causada pela presença de larvas moscas em órgãos ou tecidos do homem e outros animais. Sua localização preferida humanos na pele, com ocorrências descritas nas cavidades naturais. Seu tratamento baseado remoção mecânica das no desbridamento cirúrgico desvitalizados. OBJETIVO: descrição caso um paciente prolapso retal associado à infestação por miíase, discutindo sua incidência, sintomatologia tratamento. RELATO DO CASO: L.C.S, 36 anos, masculino, há ano....
Abstract Introduction Since the 1960s, mortality in Crohn's disease and Ulcerative Colitis patients had a significant decrease due to advances medical surgical therapy. An important proportion of these are submitted procedures during their course, with postoperative between 4 10%. Methods 157 inflammatory bowel therapy were retrospectively identified allocated 2 groups (Crohn's colitis). Deaths individually discriminated detail. Results 281 performed. In colitis group, 43 operations...
INTRODUÇÃO: projeções mostram que em 2020, os idosos constituirão cerca de 13% da população brasileira. Esta transformação não é apenas demográfica, mas também epidemiológica. Há real necessidade maior compreensão prevalência determinadas doenças na faixa etária geriátrica. OBJETIVO: avaliar queixas e diagnósticos coloproctologia mais prevalentes acima 60 anos, comparando-os com idade inferior. Avaliar o número encaminhados a procedimentos cirúrgicos, suas comorbidades analisar as...
Introdução: o estadiamento patológico com a análise do número de linfonodos dissecados é fator importante na determinação da segurança oncológica das ressecções por câncer colorretal, independentemente via acesso. Em fase inicial curva aprendizado em laparoscopia equivalência entre cirurgia convencional e laparoscópica pode ser comprometida. O objetivo presente estudo foi analisar espécimes colorretal pela laparoscópica, verificar ambas. Método: retrospectivo uma série casos pacientes...