A5101917084- Inflammatory Bowel Disease
- Microscopic Colitis
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Eosinophilic Esophagitis
- Reproductive System and Pregnancy
- Autoimmune and Inflammatory Disorders
- Liver Disease Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- Celiac Disease Research and Management
- Iron Metabolism and Disorders
- Healthcare Systems and Reforms
- Hepatitis Viruses Studies and Epidemiology
- Stoma care and complications
- Biosimilars and Bioanalytical Methods
- Immunodeficiency and Autoimmune Disorders
- COVID-19 and healthcare impacts
- Pharmaceutical Economics and Policy
- Fungal Infections and Studies
- Gastrointestinal disorders and treatments
- Gynecological conditions and treatments
- SARS-CoV-2 and COVID-19 Research
- Colorectal Cancer Surgical Treatments
- Mycobacterium research and diagnosis
- T-cell and Retrovirus Studies
Universidade de São Paulo
2015-2025
Clinics Hospital of Ribeirão Preto
2019-2025
Universidade da Amazônia
2025
Universidade de Ribeirão Preto
2010-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2023
Universidade Brasil
2020
Abstract Background Vedolizumab (VDZ) is an α4β7 integrin antibody used to treat moderate-to-severe ulcerative colitis (UC) and Crohn’s disease (CD). We aimed assess the real-life long-term effectiveness safety of VDZ as a first- or second-line biological therapy identify predictors efficacy in large cohort patients with refractory difficult-to-treat UC. Methods This was multicenter, retrospective observational study including moderately-to-severely active UC who received for at least 12...
Abstract Background Ustekinumab (UST), an antibody targeting the p40 subunit of interleukin-12/23, has demonstrated efficacy in patients with Crohn’s disease (CD). However, comparative real-world data regarding positioning biologic therapies, particularly UST versus anti-tumour necrosis factor (TNF) agents, remain limited. This study aimed to compare effectiveness and safety anti-TNF agents biologic-naïve biologic-failure CD patients. Methods A multicentre retrospective cohort was conducted,...
Objectives This study aims to identify, in scientific productions, the main impacts of COVID- 19 pandemic on monitoring chronic diseases elderly Primary Health Care (PHC). Methodology: The search was carried out using VHL database, applying inclusion criteria and descriptors. initial found 96 articles. A total 95 full-text articles were selected, 34 which Portuguese. After analyzing title abstract, 23 chosen, 11 excluded, resulting 10 final for analysis. Results: analysis indicated that has...
To assess the real-life, long-term effectiveness and safety of tofacitinib in a large cohort patients with refractory or difficult-to-treat ulcerative colitis (UC). This multicenter, retrospective, observational study included moderately to severely active UC who received for at least 8 weeks. Clinical remission response, endoscopic response remission, biochemical steroid-free clinical primary secondary loss drug discontinuation, need dose optimization, colectomy, adverse events were...
Objective: To investigate the level of knowledge among male population regarding Men's Health Program in municipality Belém-PA. Methods: This is a cross-sectional study with quantitative approach, conducted 174 individuals aged 20 to 59 years. Participants were assessed based on their understanding Program. The was evaluated through questionnaire scored from 0 5 points, considering factors such as population's attendance primary care services and possible strategies for healthcare...
As the mechanisms leading to persistence of hepatitis B virus (HBV) infection are poorly understood and as histocompatibility leucocyte antigen (HLA)-G is well described a tolerogenic molecule, we evaluated HLA-G expression in 74 specimens HBV liver biopsies 10 obtained from previously healthy cadaver donors. were reviewed classified by METAVIR score, was assessed immunohistochemistry. No observed control hepatocytes. In contrast, 57 (77%) showed soluble membrane-bound hepatocytes, biliary...
Abstract Background Real-world data on the effectiveness and safety of ustekinumab (UST) in ulcerative colitis (UC) are lacking Latin America. In this study, we aimed to describe UST a real-world multicenter cohort Brazilian patients with UC. Methods We conducted retrospective observational including moderate-to-severe UC (total Mayo score 6–12, an endoscopic subscore 2 or 3) who received UST. The co-primary endpoints were clinical remission, defined as total ≤2 at 1 year, combined rectal...
Introduction. Few studies have evaluated the factors involved in spontaneous HBsAg seroclearance patients with chronic hepatitis B (HBV) followed up on a long-term basis from areas low prevalence of HBV infection. We aimed to determine rate and related it infection at Hepatitis Outpatient Clinic HCFMRP 1992-2008. Materials methods. A total 548 (366 182 inactive carriers) were for 15 years 9 months an annual measurement HBV-DNA, ALT, AST GGT (average 4 determinations) serology (HBsAg, HBeAg,...
Summary This study evaluated the association of polymorphisms in IL-18 (−607C/A and −137C/G), IFNγ (+874 A/T), TNF (−238 A/G −308 A/G) genes with susceptibility to HBV infection severity liver injury. A total 259 chronic HBV-infected patients followed at University Hospital, Faculty Medicine Ribeirão Preto, São Paulo, Brazil, 202 healthy individuals were studied. Four Single Nucleotide Polymorphisms (SNPs) amplified by Polymerase Chain Reaction (PCR). Liver biopsy was performed 212...
Abstract Human leukocyte antigen‐G ( HLA ‐G) is a nonclassical class I molecule involved in tumor escape mechanisms. Considering that the ‐G 14bp insertion/deletion polymorphism located at 3′ untranslated region (3′ UTR ) exon 8, and since it has been associated with magnitude of production, we studied association risk developing hepatocellular carcinoma HCC ). A total 109 patients followed University Hospital, Faculty Medicine Ribeirão Preto, São Paulo, Brazil, 202 healthy controls from...
Hepatitis B virus (HBV) is distributed worldwide, with geographical variations regarding prevalence of the different genotypes. The aim this study was to determine HBV genotypes and subgenotypes circulating in Southeast Brazil compare genetic sequences found previously described world. Sequences from 166 chronic carriers were analyzed using fragment constituted by 1306 base pairs comprising surface polymerase regions genome. obtained submitted phylogenetic analysis. A1, A2, D1-D4, F2a, F4...
INTRODUCTION: Hepatitis B is common in Brazil, although there are regional differences regarding the degree of endemicity, most frequent forms transmission and presence different evolutive stages chronic disease. The present study aimed to determine clinical, demographic epidemiological characteristics patients chronically infected with hepatitis virus (HBV) residing Ribeirão Preto region, southeastern Brazil. METHODS: A total 529 medical records individuals HBV monoinfection were reviewed....
ABSTRACT BACKGROUND: Data regarding the prevalence of anemia in inflammatory bowel disease (IBD) patients are scarce Brazil. Anemia and iron deficiency have been known to cause significant functional impairment, lower quality life, higher morbidity mortality may be correlated with an impact on cost treatment. OBJECTIVE: The aim this study was estimate risk factors for IBD a tertiary unit Southeast METHODS: We conducted Institutional Review Board-approved retrospective analysis adult cohort...
BACKGROUND Antibodies against tumor necrosis factor alpha (anti-TNF-alpha) are currently widely used in the treatment of inflammatory bowel diseases (IBD), despite a number reported adverse effects. Diverse neurologic syndromes, including Guillain-Barre syndrome (GBS), an immune-mediated disease characterized by evolving ascending limb weakness, sensory loss, and areflexia, have been described association with anti-TNF-alpha therapy. CASE REPORT A 45-year-old White woman was follow-up...
Background and aims: Brazilian patients with inflammatory bowel diseases (IBD) requiring therapy biological agents usually have access to medicines through the National Unified Health Care System (SUS). This study aimed analyze IBD patient perception regarding (availability provision quality) high-cost drugs in public health care system. Methods: A questionnaire-based survey was carried out an referral center Brazil. All adult established diagnosis of ulcerative colitis (UC) or Crohn’s...
BACKGROUND AND AIM: The durability of the sustained virologic response (SVR) in patients with chronic hepatitis C after treatment and ideal follow-up time for these remains undefined. objective study was to evaluate followed up at least 12 months SVR HCFMRP-USP. METHODS: conducted on 174 treated different antiviral regimens who had achieved SVR. Qualitative serum HCV-RNA determined by commercial kit (COBAS AMPLICOR HCV, v2.0). RESULTS: There predominance male (73%) a mean age 45.6 ± 10...
In real-world experience, the number of patients using vedolizumab as first-line biological therapy was low. We aimed to evaluate effectiveness and safety in mild-to-moderate Crohn's disease (CD) biologic-naïve patients.We performed a retrospective multicentric cohort study with who had clinical activity scores (Harvey-Bradshaw Index [HBI]) measured at baseline weeks 12, 26, 52, well last follow-up. Clinical response defined reduction ≥3 HBI, whereas remission HBI ≤4. Mucosal healing...
BACKGROUND In Brazil, few studies have investigated the prevalence of infection with precore (PC) and basal core promoter (BCP) mutants hepatitis B virus (HBV). OBJECTIVES This study aimed to analyse frequency PC BCP mutations among patients infected HBV evaluate association between variants advanced hepatic disease. METHODS A total 161 were studied. To identify mutations, a 501-bp fragment DNA was amplified sequenced. FINDINGS regions from strains successfully sequenced in 129 118 cases,...
Primary gastric non-Hodgkin's lymphoma (NHL) is a co-morbidity that can be observed during the clinical course of acquired immunodeficiency syndrome (AIDS). We evaluated prevalence, clinical-evolutive aspects and form endoscopic presentation primary NHL associated with AIDS. Two hundred forty-three HIV patients were submitted to upper digestive endoscopy, evaluation clinical, histological data. A CD4 count was made by flow cytometry viral load determined in branched-DNA assay. Six cases...
The durability of the sustained virologic response (SVR) in patients with chronic hepatitis C after treatment and ideal follow-up time for these remains undefined. objective study was to evaluate followed up at least 12 months SVR HCFMRP-USP. : conducted on 174 treated different antiviral regimens who had achieved SVR. Qualitative serum HCV-RNA determined by commercial kit (COBAS AMPLICOR HCV, v2.0). There predominance male (73%) a mean age 45.6 ± 10 years. Liver cirrhosis present 16.1%...
This study aims to determine whether risk factors at the time of diagnosis that are found be predictive proximal dis- ease extension in ulcerative proctitis (UP) occur a cohort Brazilian patients.This is retrospective analysis data from 97 patients (67% female) with UP (Montreal classification: E1) least 12 months follow-up who were admitted Ribeirão Preto Medical School IBD referral center between January 2001 and December 2018. Proximal disease extension, which was defined as E1...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease which affects the colorectal mucosa with relapsing-remitting pattern. The therapeutic options currently available for medical management of UC include many options. Tofacitinib an oral small molecule, Janus kinase (JAK) inhibitor, more selective JAK1 and JAK3, reduces process involved in pathogenesis UC.Retrospective observational multicentric study patients who used tofacitinib any phase their treatment. Clinical remission...